Successful mucosal incision-assisted biopsy for the histological diagnosis of duodenal lymphoma: A case report

Morishita,Asahiro; Mori,Hirohito; Kobara,Hideki; Nishiyama,Noriko; Fujihara,Shintaro; Yachida,Tatsuo; Ayaki,Maki; Matsunaga,Tae; Sakamoto,Teppei; Maeda,Emiko; Nomura,Takako; Tani,Joji; Miyoshi,Hisaaki; Yoneyama,Hirohito; Himoto,Takashi; Kagawa,Seiko; Haba,Reiji; Masaki,Tsutomu

doi:10.3892/ol.2015.3973

January-2016 Volume 11 Issue 1

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January-2016 Volume 11 Issue 1

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Case Report Open Access

Successful mucosal incision-assisted biopsy for the histological diagnosis of duodenal lymphoma: A case report

Authors:
- Asahiro Morishita
- Hirohito Mori
- Hideki Kobara
- Noriko Nishiyama
- Shintaro Fujihara
- Tatsuo Yachida
- Maki Ayaki
- Tae Matsunaga
- Teppei Sakamoto
- Emiko Maeda
- Takako Nomura
- Joji Tani
- Hisaaki Miyoshi
- Hirohito Yoneyama
- Takashi Himoto
- Seiko Kagawa
- Reiji Haba
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan, Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kita, Kagawa 761-0793, Japan

Copyright: © Morishita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 531-534
|
Published online on: November 25, 2015

https://doi.org/10.3892/ol.2015.3973
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Abstract

Tissue sampling of primary duodenal lymphoma is essential for its histological diagnosis. Endoscopic ultrasound‑guided fine-needle aspiration (EUS-FNA), which is frequently used for submucosal tumor (SMT)-like duodenal tumors, is adequate for cytological diagnosis, but not for histological diagnosis. Therefore, in the present study, a mucosal incision-assisted biopsy (MIAB) was performed in an 81‑year‑old woman for the diagnosis of an SMT-like duodenal mass, as tissue sampling for histological analysis using a regular endoscopic biopsy had failed to establish a definite diagnosis of malignant lymphoma. EUS-FNA had also led to poor tissue sampling due to the difficult location of the duodenal tumor. The pathological examination of biopsy samples using MIAB revealed the presence of a diffuse proliferation of atypical lymphocytes, and the expression of cluster of differentiation (CD)20 and CD79a, but no expression of CD3 in the tumor specimens. The patient was diagnosed with diffuse large B-cell lymphoma. To the best of knowledge, this is first report of a case using MIAB as a sampling method for the histological diagnosis of SMT-like primary duodenal lymphoma. This case suggests that MIAB may be an essential method for obtaining tissue samples from SMT-like duodenal tumors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Successful mucosal incision-assisted biopsy for the histological diagnosis of duodenal lymphoma: A case report

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Abstract

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