Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report

  • Authors:
    • Liang‑Yu Chen
    • Ming‑Hsui Tsai
    • Li‑Tai Tsai
    • Hsin‑Man Lu
    • Chia‑Ing Jan
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology ‑ Head and Neck Surgery, China Medical University and Hospital, Taichung 40402, Taiwan, R.O.C., Department of Psychology, Asia University, Taichung 41354, Taiwan, R.O.C., Department of Pathology, China Medical University Hospital, Taichung 40402, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 921-924
    |
    Published online on: November 30, 2015
       https://doi.org/10.3892/ol.2015.3980
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reports the case of a 24-year-old female affected with primary Sjögren's syndrome (pSS), who presented with mucosa‑associated lymphoid tissue (MALT) lymphoma of the submandibular gland. Reports of such cases, particularly in young patients, are very rare. The patient, who presented no oral or ocular symptoms prior to the development of the mass, underwent surgical ablation of the gland, and MALT lymphoma was diagnosed by histopathology. Since MALT lymphoma in the submandibular gland is rarely observed in otherwise healthy young females, a rheumatologist and an oncologist were consulted. Following a number of immunological tests, the results of the Schirmer's and Saxon tests were negative. However, the antinuclear antibody test revealed a speckled appearance, and there was also strong positivity for the serological markers of Sjögren's syndrome. Consequently, pSS was diagnosed, despite the fact that the patient did not fulfill all the diagnostic criteria for the disease. Therefore, MALT lymphoma in a single salivary gland should be used as a differential diagnosis for Sjögren's syndrome in young asymptomatic patients. Additionally, a multidisciplinary team is required for the treatment and management of these patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Fox RI: Sjogren's syndrome. Lancet. 366:321–331. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kassan SS and Moutsopoulos HM: Clinical manifestations and early diagnosis of Sjogren syndrome. Arch Intern Med. 164:1275–1284. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Ramos-Casals M, Cervera R, Font J, García-Carrasco M, Espinosa G, Reino S, Pallarés L and Ingelmo M: Young onset of primary Sjögren's syndrome, Clinical and immunological characteristics. Lupus. 7:202–206. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Qin B, Wang J, Yang Z, Yang M, Ma N, Huang F and Zhong R: Epidemiology of primary Sjögren's syndrome, A systematic review and meta-analysis. Ann Rheum Dis. 74:1983–1989. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Singh AG, Singh S and Matteson EL: Rate, risk factors and causes of mortality in patients with Sjögren's syndrome A. systematic review and meta-analysis of cohort studies. Rheumatology (Oxford). 2015.[Epub ahead of print] 2015. View Article : Google Scholar

6 

Fazaa A, Bourcier T, Chatelus E, Sordet C, Theulin A, Sibilia J and Gottenberg JE: Classification criteria and treatment modalities in primary Sjögren's syndrome. Expert Rev Clin Immunol. 10:543–551. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Thieblemont C, Bertoni F, Copie-Bergman C, Ferreri AJ and Ponzoni M: Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type. Semin Cancer Biol. 24:33–42. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Lee SE, Paik JS, Cho WK, Choi BO, Lee SN, Jung SE, Park KS, Kang CS, Kim SH, Yang SW and Cho SG: Feasibility of the TNM-based staging system of ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Am J Hematol. 86:262–266. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Vazquez A, Khan MN, Sanghvi S, et al: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the salivary glands: a population-based study from 1994 to 2009. Head Neck. 37:18–22. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Voulgarelis M, Dafni UG, Isenberg DA and Moutsopoulos HM: Malignant lymphoma in primary Sjögren's syndrome, A multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's syndrome. Arthritis Rheum. 42:1765–1772. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Anacak Y, Miller RC, Constantinou N, Mamusa AM, Epelbaum R, Li Y, Calduch AL, Kowalczyk A, Weber DC, Kadish SP, et al: Primary mucosa- associated lymphoid tissue lymphoma of the salivary glands: A multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys. 82:315–320. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Movahed R, Weiss A, Velez I and Dym H: Submandibular gland MALT lymphoma associated with Sjögren's syndrome, Case report. J Oral Maxillofac Surg. 69:2924–2929. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Maślińska M, Przygodzka M, Kwiatkowska B and Sikorska-Siudek K: Sjögren's syndrome Still not fully understood disease. Rheumatol Int. 35:233–241. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kassan SS, Thomas TL, Moutsopoulos HM, Hoover R, Kimberly RP, Budman DR, Costa J, Decker JL and Chused TM: Increased risk of lymphoma in sicca syndrome. Ann Intern Med. 89:888–892. 1978. View Article : Google Scholar : PubMed/NCBI

15 

Routsias JG, Goules JD, Charalampakis G, Tzima S, Papageorgiou A and Voulgarelis M: Malignant lymphoma in primary Sjögren's syndrome, An update on the pathogenesis and treatment. Semin Arthritis Rheum. 43:178–186. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Cho CM, Tong SL, Bhatia KS, Wong KT, Yuen HY, Lee YP and Ahuja AT: Unusual parotid gland lesions, A pictorial review. J Clin Ultrasound. 41:501–508. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Rastogi R, Bhargava S, Mallarajapatna GJ and Singh SK: Pictorial essay, Salivary gland imaging. Indian J Radiol Imaging. 22:325–333. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, et al: Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups: American College of Rheumatology classification criteria for Sjögren's syndrome: A data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 64:475–487. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Wenzel C, Fiebiger W, Dieckmann K, Formanek M, Chott A and Raderer M: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area, High rate of disease recurrence following local therapy. Cancer. 97:2236–2241. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Pollard RP, Pijpe J, Bootsma H, Spijkervet FK, Kluin PM, Roodenburg JL, Kallenberg CG, Vissink A and van Imhoff GW: Treatment of mucosa-associated lymphoid tissue lymphoma in Sjogren's syndrome. A retrospective clinical study. J Rheumatol. 38:2198–2208. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen LY, Tsai MH, Tsai LT, Lu HM and Jan CI: Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncol Lett 11: 921-924, 2016.
APA
Chen, L., Tsai, M., Tsai, L., Lu, H., & Jan, C. (2016). Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncology Letters, 11, 921-924. https://doi.org/10.3892/ol.2015.3980
MLA
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11.2 (2016): 921-924.
Chicago
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11, no. 2 (2016): 921-924. https://doi.org/10.3892/ol.2015.3980
Copy and paste a formatted citation
x
Spandidos Publications style
Chen LY, Tsai MH, Tsai LT, Lu HM and Jan CI: Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncol Lett 11: 921-924, 2016.
APA
Chen, L., Tsai, M., Tsai, L., Lu, H., & Jan, C. (2016). Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncology Letters, 11, 921-924. https://doi.org/10.3892/ol.2015.3980
MLA
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11.2 (2016): 921-924.
Chicago
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11, no. 2 (2016): 921-924. https://doi.org/10.3892/ol.2015.3980
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team