Primary intratesticular rhabdomyosarcoma: A case report and literature review

Yi,Jun; Zhou,Dong‑Ai; Huo,Ji‑Rong; Wang,Yun‑Hua; Ma,Jin‑An

doi:10.3892/ol.2015.3987

Primary intratesticular rhabdomyosarcoma: A case report and literature review

Authors:
- Jun Yi
- Dong‑Ai Zhou
- Ji‑Rong Huo
- Yun‑Hua Wang
- Jin‑An Ma
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Affiliations: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China, Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China, Positron Emission Tomography‑Computed Tomography Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China
Published online on: December 2, 2015 https://doi.org/10.3892/ol.2015.3987
Pages: 1016-1020

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Abstract

Rhabdomyosarcoma (RMS) that primarily occurs in the testes is particularly rare, with only retrospective studies and sporadic cases reported in the literature. The present study describes the case of a large, primary intratesticular RMS (ITRMS) that was treated with a radical inguinal orchiectomy (RIO) and a regimen of chemotherapy. The study also presents a review of the literature regarding primary ITRMSs, aiming to elucidate the clinical characteristics and optimal treatment of the disease. A 14‑year‑old male presented with a 1‑year history of a slow‑growing, painless, left scrotal mass. Magnetic resonance imaging identified a mass in the left scrotum with mixed signal intensity; no abnormal signals were identified in the right testicle and retroperitoneal lymph node. An X‑ray of the chest demonstrated no evidence of metastasis. Subsequent to this, a left RIO was performed. Histopathological and immunohistochemical examination confirmed the final diagnosis of embryonal ITRMS. At 21 days post-surgery, an 18F-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG‑PET‑CT) scan identified widespread metastatic lesions in the lungs, local lymph nodes and bones, presenting as increased glucose metabolism nodules. Subsequently, the patient received six sequential cycles of adjunct chemotherapy. The patient is alive with disease in October 2015. The case described is noteworthy as it is an example of ITRMS, in which the patient received successful treatment. However, multidisciplinary treatment may further improve the outcome of the disease.

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