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Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression

  • Authors:
    • Dae Hyun Song
    • Gyung Hyuck Ko
    • Jeong Hee Lee
    • Jong Sil Lee
    • Gyeong‑Won Lee
    • Hyeon Cheol Kim
    • Jung Wook Yang
    • Rok Won Heo
    • Gu Seob Roh
    • Sun‑Young Han
    • Dong Chul Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Gyeonsang National University School of Medicine, Jinju, Gyeongsang 660‑751, Republic of Korea, Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, Gyeongsang 660‑751, Republic of Korea, Department of Pathology, Gyeongsang National University Hospital, Jinju, Gyeongsang 660‑751, Republic of Korea, Department of Pharmacology, College of Pharmacy, Gyeongsang National University, Jinju, Gyeongsang 660‑751, Republic of Korea
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 998-1006
    |
    Published online on: December 2, 2015
       https://doi.org/10.3892/ol.2015.3988
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Abstract

Myoferlin is a protein that is associated with cellular repair following injury. The expression of myoferlin in breast cancer and pancreatic adenocarcinoma has been reported to correlate with tumor invasiveness, epithelial to mesenchymal transition and an adverse prognosis. In the present study, myoferlin expression was investigated in non‑small cell lung carcinoma (NSCLC), along with its association with patient prognosis and the expression of a number of other proteins. A total of 148 patients exhibiting NSCLC were enrolled in the present study. The survival data of all patients was examined, and myoferlin, vascular endothelial growth factor receptor‑2 (VEGFR‑2), epidermal growth factor receptor, E‑cadherin, β‑catenin, thyroid transcription factor‑1 and tumor protein p63 expression was investigated via immunohistochemical staining of tissue microarrays. Myoferlin expression was detected in the cytoplasm of 75/148 (50.7%) of the NSCLC cases. In the adenocarcinoma cases, myoferlin‑positive patients possessed a poorer prognosis (odds ratio, 2.94; P=0.339). In the squamous cell carcinoma cases, myoferlin expression was significantly associated with VEGFR‑2 expression (P=0.001). Immunohistochemical staining for VEGFR‑2 and myoferlin expression indicated similar features and cytoplasmic staining in tumor cells. As VEGFR‑2 is a significant target for novel anticancer therapies, it is anticipated that myoferlin may also possess the potential to become a novel clinical target for the treatment of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Song DH, Ko GH, Lee JH, Lee JS, Lee GW, Kim HC, Yang JW, Heo RW, Roh GS, Han SY, Han SY, et al: Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncol Lett 11: 998-1006, 2016.
APA
Song, D.H., Ko, G.H., Lee, J.H., Lee, J.S., Lee, G., Kim, H.C. ... Kim, D.C. (2016). Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncology Letters, 11, 998-1006. https://doi.org/10.3892/ol.2015.3988
MLA
Song, D. H., Ko, G. H., Lee, J. H., Lee, J. S., Lee, G., Kim, H. C., Yang, J. W., Heo, R. W., Roh, G. S., Han, S., Kim, D. C."Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression". Oncology Letters 11.2 (2016): 998-1006.
Chicago
Song, D. H., Ko, G. H., Lee, J. H., Lee, J. S., Lee, G., Kim, H. C., Yang, J. W., Heo, R. W., Roh, G. S., Han, S., Kim, D. C."Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression". Oncology Letters 11, no. 2 (2016): 998-1006. https://doi.org/10.3892/ol.2015.3988
Copy and paste a formatted citation
x
Spandidos Publications style
Song DH, Ko GH, Lee JH, Lee JS, Lee GW, Kim HC, Yang JW, Heo RW, Roh GS, Han SY, Han SY, et al: Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncol Lett 11: 998-1006, 2016.
APA
Song, D.H., Ko, G.H., Lee, J.H., Lee, J.S., Lee, G., Kim, H.C. ... Kim, D.C. (2016). Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncology Letters, 11, 998-1006. https://doi.org/10.3892/ol.2015.3988
MLA
Song, D. H., Ko, G. H., Lee, J. H., Lee, J. S., Lee, G., Kim, H. C., Yang, J. W., Heo, R. W., Roh, G. S., Han, S., Kim, D. C."Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression". Oncology Letters 11.2 (2016): 998-1006.
Chicago
Song, D. H., Ko, G. H., Lee, J. H., Lee, J. S., Lee, G., Kim, H. C., Yang, J. W., Heo, R. W., Roh, G. S., Han, S., Kim, D. C."Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression". Oncology Letters 11, no. 2 (2016): 998-1006. https://doi.org/10.3892/ol.2015.3988
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