Open Access

Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors

  • Authors:
    • Lu‑Ying Wang
    • Lan‑Shuang Li
    • Zhu Yang
  • View Affiliations

  • Published online on: December 3, 2015     https://doi.org/10.3892/ol.2015.3996
  • Pages: 933-938
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Transcriptional factor FOXC1 has been demonstrated to play a key role in embryogenesis in animal studies and may participate in tumorigenesis. However, the specific function of this gene in ovarian tumors has not been fully determined. In this study, potential correlations between FOXC1 expression and clinicopathological features of serous ovarian tumors were investigated. FOXC1 expression was analyzed in SKOV‑3 and HO‑8910 cell lines and serous ovarian tumor tissues. A significant correlation was observed between FOXC1 protein expression and pathological subtype as well as FIGO stage (P<0.05) in serous ovarian tumors in our retrospective study. No significant association was revealed between FOXC1 protein expression and the clinicopathological factors of age, histological grade and volume of ascites (P>0.05). The results suggest that high expression of FOXC1 protein may serve as a marker for benign serous ovarian tumors and a suggest a trend towards good prognosis.
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February-2016
Volume 11 Issue 2

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Spandidos Publications style
Wang LY, Li LS and Yang Z: Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors. Oncol Lett 11: 933-938, 2016
APA
Wang, L., Li, L., & Yang, Z. (2016). Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors. Oncology Letters, 11, 933-938. https://doi.org/10.3892/ol.2015.3996
MLA
Wang, L., Li, L., Yang, Z."Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors". Oncology Letters 11.2 (2016): 933-938.
Chicago
Wang, L., Li, L., Yang, Z."Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors". Oncology Letters 11, no. 2 (2016): 933-938. https://doi.org/10.3892/ol.2015.3996