Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC‑7721 cells

  • Authors:
    • Lisha Tang
    • Xiaofeng Jin
    • Xiaohui Hu
    • Xiaoding Hu
    • Zulong Liu
    • Long Yu
  • View Affiliations

  • Published online on: December 3, 2015     https://doi.org/10.3892/ol.2015.4002
  • Pages: 1173-1178
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Abstract

Liver cancer is one of the most common types of cancer, and hepatoma demonstrates a poor long‑term prognosis. The present study reports that glaucocalyxin A (GLA), a natural product isolated from Rabdosia umbrosa, inhibits the growth of the liver cancer Focus and SMMC‑7721 cell lines in a dose‑ and time‑dependent manner. The present study revealed that GLA arrested the liver cancer cells at the G2/M stage of the cell cycle and led to decreased expression of caspase 3 and the cleavage of poly(adenosine diphosphate‑ribose) polymerase. Overall, the present study demonstrated that GLA inhibits the growth of liver cancer cells by G2/M stage cell‑cycle arrest and cell apoptosis.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Tang L, Jin X, Hu X, Hu X, Liu Z and Yu L: Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC‑7721 cells. Oncol Lett 11: 1173-1178, 2016
APA
Tang, L., Jin, X., Hu, X., Hu, X., Liu, Z., & Yu, L. (2016). Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC‑7721 cells. Oncology Letters, 11, 1173-1178. https://doi.org/10.3892/ol.2015.4002
MLA
Tang, L., Jin, X., Hu, X., Hu, X., Liu, Z., Yu, L."Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC‑7721 cells". Oncology Letters 11.2 (2016): 1173-1178.
Chicago
Tang, L., Jin, X., Hu, X., Hu, X., Liu, Z., Yu, L."Glaucocalyxin A inhibits the growth of liver cancer Focus and SMMC‑7721 cells". Oncology Letters 11, no. 2 (2016): 1173-1178. https://doi.org/10.3892/ol.2015.4002