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Article Open Access

Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor

  • Authors:
    • Hana Študentová
    • Jarmila Indráková
    • Pavla Petrová
    • Milan Kamínek
    • Hana Kalábová
    • Vlastislav Šrámek
    • Tomáš Adam
    • Bohuslav Melichar
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc 775 20, Czech Republic, Department of Medicine, Palacký University Medical School and Teaching Hospital, Olomouc 775 20, Czech Republic, Department of Clinical Biochemistry, Palacký University Medical School and Teaching Hospital, Olomouc 775 20, Czech Republic, Department of Nuclear Medicine, Palacký University Medical School and Teaching Hospital, Olomouc 775 20, Czech Republic
    Copyright: © Študentová et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 939-944
    |
    Published online on: December 9, 2015
       https://doi.org/10.3892/ol.2015.4017
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Abstract

The aim of the present study was to examine the changes in intima‑media thickness (IMT) and myocardial perfusion in association with other laboratory risk factors for atherosclerosis in patients treated with therapy that targeted vascular endothelial growth factor (VEGF). IMT, myocardial perfusion and laboratory risk factors of atherosclerosis were studied in 58 patients with metastatic colorectal carcinoma or metastatic renal cell carcinoma prior to and at 3‑monthly intervals during anti‑VEGF treatment. Compared with the pretreatment IMT, the results indicated that the IMT was consistently increased during therapy in the two patient groups. Patient blood pressure and concentration of troponin T increased transiently. An increase in the concentration of high‑density lipoprotein cholesterol and decrease in the concentrations of C‑reactive protein and homocysteine were also observed. Novel myocardial ischemia was evident in individual patients. In conclusion, anti‑VEGF therapy affects the laboratory risk factors of atherosclerosis and results in an acceleration of atherosclerosis, as demonstrated by increased IMT.
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1 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Buchler T, Klapka R, Melichar B, Brabec P, Dusek L, Vyzula R and Abrahamova J: Sunitinib followed by sorafenib or vice versa for metastatic renal cell carcinoma - data from the Czech registry. Ann Oncol. 23:395–401. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, et al: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial. Lancet. 378:1931–1939. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bennouna J, Sastre J, Arnold D, Österlund P, Greil R, Van Cutsem E, von Moos R, Viéitez JM, Bouché O, Borg C, et al: ML18147 Study Investigators: Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial. Lancet Oncol. 14:29–37. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Rini BI, Melichar B, Ueda T, Grünwald V, Fishman MN, Arranz JA, Bair AH, Pithavala YK, Andrews GI, Pavlov D, et al: Axitinib with or without dose titration for first-line metastatic renal-cell carcinoma: A randomised double-blind phase 2 trial. Lancet Oncol. 14:1233–1242. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, et al: CORRECT Study Group: Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 381:303–312. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Melichar B, Bracarda S, Matveev V, Alekseev B, Ivanov S, Zyryanov A, Janciauskiene R, Fernebro E, Mulders P, Osborne S, et al: BEVLiN Investigators: A multinational phase II trial of bevacizumab with low-dose interferon-α2a as first-line treatment of metastatic renal cell carcinoma: BEVLiN. Ann Oncol. 24:2396–2402. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, dos Santos LV, Aprile G, Ferry DR, et al: REGARD Trial Investigators: Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 383:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausová J, Macarulla T, Ruff P, van Hazel GA, Moiseyenko V, Ferry D, et al: Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol. 30:3499–3506. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Melichar B and Nemcová I: Eye complications of cetuximab therapy. Eur J Cancer Care (Engl). 16:439–443. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Melichar B, Králíčková P, Hyšpler R, Kalábová H, Cerman J Jr, Holečková P, Studentová H and Malířová E: Hypomagnesaemia in patients with metastatic colorectal carcinoma treated with cetuximab. Hepatogastroenterology. 59:366–371. 2012.PubMed/NCBI

13 

Melichar B, Hyšpler R, Tichá A, Kalábová H, Vitásková D, Zezulová M, Dvořák J, Cerman J Jr and Doležel M: Intestinal permeability in patients with metastatic colon cancer treated with patupilone. Clin Chem Lab Med. 52:1649–1655. 2014.PubMed/NCBI

14 

Melichar B, Dvorák J, Hyspler R and Zadák Z: Intestinal permeability in the assessment of intestinal toxicity of cytotoxic agents. Chemotherapy. 51:336–338. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Melichar B, Kohout P, Brátová M, Solichová D, Králícková P and Zadák Z: Intestinal permeability in patients with chemotherapy-induced stomatitis. J Cancer Res Clin Oncol. 127:314–318. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Geiger S, Lange V, Suhl P, Heinemann V and Stemmler HJ: Anticancer therapy induced cardiotoxicity, Review of the literature. Anticancer Drugs. 21:578–590. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Huddart RA, Norman A, Shahidi M, Horwich A, Coward D, Nicholls J and Dearnaley DP: Cardiovascular disease as a long-term complication of treatment for testicular cancer. J Clin Oncol. 21:1513–1523. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Meinardi MT, Gietema JA, van der Graaf WTA, van Veldhuisen DJ, Runne MA, Sluiter WJ, de Vries EG, Willemse PB, Mulder NH, van den Berg MP, et al: Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J Clin Oncol. 18:1725–1732. 2000.PubMed/NCBI

19 

Zagars GK, Ballo MT, Lee AK and Strom SS: Mortality after cure of testicular seminoma. J Clin Oncol. 22:640–647. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Kalábová H, Melichar B, Ungermann L, Doležal J, Krčmová L, Kašparová M, Plíšek J, Hyšpler R, Pecka M and Solichová D: Intima-media thickness, myocardial perfusion and laboratory risk factors of atherosclerosis in patients with breast cancer treated with anthracycline-based chemotherapy. Med Oncol. 28:1281–1287. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Melichar B, Kalábová H, Krcmová L, Kasparová M, Malírová E, Melicharová K, Pecka M, Hyspler R and Solichová D: Serum homocysteine, cholesterol, retinol, alpha-tocopherol, glycosylated hemoglobin and inflammatory response during therapy with bevacizumab, oxaliplatin, 5-fluorouracil and leucovorin. Anticancer Res. 29:4813–4820. 2009.PubMed/NCBI

22 

Šrámek V, Melichar B, Indrakova J, Študentová H, Kalábová H, Vrána D, Lukešová L, Adam T, Hlídková E, Juráňová J, et al: Risk factors of atherosclerosis in patients with history of breast cancer. Pteridines. 24:201–210. 2013. View Article : Google Scholar

23 

Melichar B: Laboratory medicine and medical oncology: T he tale of two Cinderellas. Clin Chem Lab Med. 51:99–112. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Floyd JD, Nguyen DT, Lobins RL, Bashir Q, Doll DC and Perry MC: Cardiotoxicity of cancer therapy. J Clin Oncol. 23:7685–7696. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Melichar B, Gregor J, Solichová D, Lukes J, Tichý M and Pidrman V: Increased urinary neopterin in acute myocardial infarction. Clin Chem. 40:338–339. 1994.PubMed/NCBI

26 

Solichova D, Melichar B, Blaha V, Klejna M, Vavrova J, Palicka V and Zadak Z: Biochemical profile and survival in nonagenarians. Clin Biochem. 34:563–569. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Melichar B, Solichová D, Melicharová K, Malírová E, Cermanová M and Zadák Z: Urinary neopterin in patients with advanced colorectal carcinoma. Int J Biol Markers. 21:190–198. 2006.PubMed/NCBI

28 

Ewer MS, Vooletich MT, Durand JB, Woods ML, Davis JR, Valero V and Lenihan DJ: Reversibility of trastuzumab-related cardiotoxicity, New insights based on clinical course and response to medical treatment. J Clin Oncol. 23:7820–7826. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Schmidinger M, Zielinski CC, Vogl UM, Bojic A, Bojic M, Schukro C, Ruhsam M, Hejna M and Schmidinger H: Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol. 26:5204–5212. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Dorff TB, Goldkorn A and Quinn DI: Targeted therapy in renal cancer. Ther Adv Med Oncol. 1:183–205. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Študentová H, Indráková J, Petrová P, Kamínek M, Kalábová H, Šrámek V, Adam T and Melichar B: Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncol Lett 11: 939-944, 2016.
APA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V. ... Melichar, B. (2016). Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncology Letters, 11, 939-944. https://doi.org/10.3892/ol.2015.4017
MLA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11.2 (2016): 939-944.
Chicago
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11, no. 2 (2016): 939-944. https://doi.org/10.3892/ol.2015.4017
Copy and paste a formatted citation
x
Spandidos Publications style
Študentová H, Indráková J, Petrová P, Kamínek M, Kalábová H, Šrámek V, Adam T and Melichar B: Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncol Lett 11: 939-944, 2016.
APA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V. ... Melichar, B. (2016). Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncology Letters, 11, 939-944. https://doi.org/10.3892/ol.2015.4017
MLA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11.2 (2016): 939-944.
Chicago
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11, no. 2 (2016): 939-944. https://doi.org/10.3892/ol.2015.4017
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