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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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February-2016 Volume 11 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report

  • Authors:
    • Shuo Zhang
    • Yong Zhang
    • Yong-Hua Yu
    • Jia Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jinan Central Hospital, Shangdong University, Jinan, Shandong 250002, P.R. China, Radiation Oncology Ward 2, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China
  • Pages: 1069-1072
    |
    Published online on: December 10, 2015
       https://doi.org/10.3892/ol.2015.4024
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Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare tumor that mainly affects adolescents, and typically involves the abdominal and pelvic peritoneum. The present study reports one case of giant DSRCT, treated with concurrent chemoradiotherapy, and reviews the available medical literature. A 38‑year‑old man presented with a 3‑month history of pain in the left lower abdomen and nausea, associated with decreased appetite and weight loss. Computed tomography (CT) showed a 12.3x7.9 cm confluent solid mass in the lower abdomen and pelvic cavity. The patient underwent exploratory laparotomy and the final pathological diagnosis was DSRCT. Following laparotomy, the patient was treated with external beam radiotherapy to the whole abdomen and pelvis to a dose of 40 Gy plus a 20 Gy boost to the residual disease. The results indicated that synchronous chemotherapy with cyclophosphamide, adriamycin and cisplatin combined with radiotherapy significantly improved locoregional control of DSRCT and a complete response, as measured by CT assessment 2 months subsequent to radiotherapy. In conclusion, DSRCT is a rare malignancy requiring multidisciplinary treatment, including surgery, chemotherapy and radiotherapy. The results of the present study confirm that radiotherapy has a significant role in the treatment of advanced abdominal DSRCT and may contribute to durable remission.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Zhang Y, Yu Y and Li J: Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report. Oncol Lett 11: 1069-1072, 2016.
APA
Zhang, S., Zhang, Y., Yu, Y., & Li, J. (2016). Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report. Oncology Letters, 11, 1069-1072. https://doi.org/10.3892/ol.2015.4024
MLA
Zhang, S., Zhang, Y., Yu, Y., Li, J."Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report". Oncology Letters 11.2 (2016): 1069-1072.
Chicago
Zhang, S., Zhang, Y., Yu, Y., Li, J."Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report". Oncology Letters 11, no. 2 (2016): 1069-1072. https://doi.org/10.3892/ol.2015.4024
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Zhang Y, Yu Y and Li J: Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report. Oncol Lett 11: 1069-1072, 2016.
APA
Zhang, S., Zhang, Y., Yu, Y., & Li, J. (2016). Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report. Oncology Letters, 11, 1069-1072. https://doi.org/10.3892/ol.2015.4024
MLA
Zhang, S., Zhang, Y., Yu, Y., Li, J."Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report". Oncology Letters 11.2 (2016): 1069-1072.
Chicago
Zhang, S., Zhang, Y., Yu, Y., Li, J."Complete response of giant desmoplastic small round cell tumor treated with chemoradiotherapy: A case report". Oncology Letters 11, no. 2 (2016): 1069-1072. https://doi.org/10.3892/ol.2015.4024
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