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Diagnosis and management of tumor-like hypophysitis: A retrospective case series

  • Authors:
    • Songxue Guo
    • Chaohui Wang
    • Jianmin Zhang
    • Yong Tian
    • Qun Wu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China, Department of Neurosurgery, Ruian People's Hospital, Wenzhou, Zhejiang 325200, P.R. China, Department of Neurosurgery, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1315-1320
    |
    Published online on: December 22, 2015
       https://doi.org/10.3892/ol.2015.4046
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Abstract

Tumor-like hypophysitis is an uncommon sellar condition that presents as inflammatory lesions on the structures of the pituitary gland. The diagnosis and management of hypophysitis poses a significant challenge, as its clinical manifestation and appearance in imaging studies are difficult to distinguish from that of pituitary tumors. The present retrospective study summarizes two rare cases of primary granulomatous hypophysitis, two cases of lymphocytic hypophysitis, and three cases in which a pathological diagnosis was not determined due to the use of hormone replacement therapy only. The mean age of the patients studied was 45.71±22.16 years, and the patients comprised two males and five females. The clinical signs of hypophysitis included headache, fever, gradual decrease in visual acuity, nausea and vomiting. Enhanced magnetic resonance imaging revealed sellar and pituitary stalk lesions, with iso- or hypodense signals on T1‑weighted images. Transsphenoidal surgery was performed in three cases. It was challenging to diagnose hypophysitis due to the lack of any significant specific clinical signs. A transsphenoidal biopsy with fast‑frozen pathology is able to diagnose hypophysitis. Glucocorticoid therapy may be a potential treatment for hypophysitis, as complete removal of pituitary masses may disable pituitary function.
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Copy and paste a formatted citation
Spandidos Publications style
Guo S, Wang C, Zhang J, Tian Y and Wu Q: Diagnosis and management of tumor-like hypophysitis: A retrospective case series. Oncol Lett 11: 1315-1320, 2016.
APA
Guo, S., Wang, C., Zhang, J., Tian, Y., & Wu, Q. (2016). Diagnosis and management of tumor-like hypophysitis: A retrospective case series. Oncology Letters, 11, 1315-1320. https://doi.org/10.3892/ol.2015.4046
MLA
Guo, S., Wang, C., Zhang, J., Tian, Y., Wu, Q."Diagnosis and management of tumor-like hypophysitis: A retrospective case series". Oncology Letters 11.2 (2016): 1315-1320.
Chicago
Guo, S., Wang, C., Zhang, J., Tian, Y., Wu, Q."Diagnosis and management of tumor-like hypophysitis: A retrospective case series". Oncology Letters 11, no. 2 (2016): 1315-1320. https://doi.org/10.3892/ol.2015.4046
Copy and paste a formatted citation
x
Spandidos Publications style
Guo S, Wang C, Zhang J, Tian Y and Wu Q: Diagnosis and management of tumor-like hypophysitis: A retrospective case series. Oncol Lett 11: 1315-1320, 2016.
APA
Guo, S., Wang, C., Zhang, J., Tian, Y., & Wu, Q. (2016). Diagnosis and management of tumor-like hypophysitis: A retrospective case series. Oncology Letters, 11, 1315-1320. https://doi.org/10.3892/ol.2015.4046
MLA
Guo, S., Wang, C., Zhang, J., Tian, Y., Wu, Q."Diagnosis and management of tumor-like hypophysitis: A retrospective case series". Oncology Letters 11.2 (2016): 1315-1320.
Chicago
Guo, S., Wang, C., Zhang, J., Tian, Y., Wu, Q."Diagnosis and management of tumor-like hypophysitis: A retrospective case series". Oncology Letters 11, no. 2 (2016): 1315-1320. https://doi.org/10.3892/ol.2015.4046
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