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Article

Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells

  • Authors:
    • Hui‑Jun Hu
    • Xiao‑Long Lin
    • Mi‑Hua Liu
    • Xiao‑Juan Fan
    • Wei‑Wen Zou
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Third People's Hospital of Huizhou, Affiliated Huizhou Hospital, Guangzhou Medical University, Huizhou, Guangdong 516002, P.R. China, Department of Clinical Laboratory, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 1499-1505
    |
    Published online on: December 28, 2015
       https://doi.org/10.3892/ol.2015.4063
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Abstract

The hepatocyte growth factor (HGF)/c‑Met signaling pathway results in cancer cell scattering and invasion, and has been reported to participate in several types of cancer, including prostate and colorectal cancer. The downstream phosphorylation cascade of HGF, particularly the mitogen‑activated protein kinase and phosphoinositide 3‑kinase/AKT signaling pathway, regulates epithelial‑mesenchymal transition (EMT). However, the mechanism by which these signaling pathways govern EMT, and whether certain kinases are able to respond to specific EMT effectors, remains to be elucidated. In the present study, an increase in the levels of vimentin, rather than co‑regulation of certain EMT marker proteins, was observed in response to HGF‑induced EMT in DU145 prostate cancer cells. In addition, it was observed that curcumin abrogated HGF‑induced DU145 cell scattering and invasion. Furthermore, curcumin was able to effectively inhibit the HGF‑induced increase in the levels of vimentin by downregulating the expression of phosphorylated c‑Met, extracellular signal‑regulated kinase and Snail. In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF‑induced EMT, possibly by inhibiting c‑Met expression in DU145 prostate cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Hu HJ, Lin XL, Liu MH, Fan XJ and Zou WW: Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells. Oncol Lett 11: 1499-1505, 2016.
APA
Hu, H., Lin, X., Liu, M., Fan, X., & Zou, W. (2016). Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells. Oncology Letters, 11, 1499-1505. https://doi.org/10.3892/ol.2015.4063
MLA
Hu, H., Lin, X., Liu, M., Fan, X., Zou, W."Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells". Oncology Letters 11.2 (2016): 1499-1505.
Chicago
Hu, H., Lin, X., Liu, M., Fan, X., Zou, W."Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells". Oncology Letters 11, no. 2 (2016): 1499-1505. https://doi.org/10.3892/ol.2015.4063
Copy and paste a formatted citation
x
Spandidos Publications style
Hu HJ, Lin XL, Liu MH, Fan XJ and Zou WW: Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells. Oncol Lett 11: 1499-1505, 2016.
APA
Hu, H., Lin, X., Liu, M., Fan, X., & Zou, W. (2016). Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells. Oncology Letters, 11, 1499-1505. https://doi.org/10.3892/ol.2015.4063
MLA
Hu, H., Lin, X., Liu, M., Fan, X., Zou, W."Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells". Oncology Letters 11.2 (2016): 1499-1505.
Chicago
Hu, H., Lin, X., Liu, M., Fan, X., Zou, W."Curcumin mediates reversion of HGF‑induced epithelial‑mesenchymal transition via inhibition of c‑Met expression in DU145 cells". Oncology Letters 11, no. 2 (2016): 1499-1505. https://doi.org/10.3892/ol.2015.4063
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