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Review

MicroRNAs in diffuse large B‑cell lymphoma (Review)

  • Authors:
    • Huiyun Ni
    • Rong Tong
    • Linqing Zou
    • Guoqi Song
    • William C. Cho
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Anatomy, Nantong University College of Medicine, Nantong, Jiangsu 226001, P.R. China, Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong 999077, P.R. China
  • Pages: 1271-1280
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    Published online on: December 28, 2015
       https://doi.org/10.3892/ol.2015.4064
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Abstract

The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B‑cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately distinguish different subtypes and prognostic classifications of DLBCL, as well as distinguish DLBCL from other more indolent lymphomas, including follicular lymphoma. miRs are excellent biomarkers for cancer diagnosis and prognosis. In DLBCL, specific miR expression profiles in the tissues of patients are associated with prognosis and clinical outcome. Over the past decade, there has been substantial investigation concerning the pathogenetic, diagnostic and prognostic roles of miRs in DLBCL. The aim of the present review is to describe the aberrant expression of miRs in DLBCL, and the functions, potential clinical use and possible therapeutic targets of miRs in this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Ni H, Tong R, Zou L, Song G and Cho WC: MicroRNAs in diffuse large B‑cell lymphoma (Review). Oncol Lett 11: 1271-1280, 2016.
APA
Ni, H., Tong, R., Zou, L., Song, G., & Cho, W.C. (2016). MicroRNAs in diffuse large B‑cell lymphoma (Review). Oncology Letters, 11, 1271-1280. https://doi.org/10.3892/ol.2015.4064
MLA
Ni, H., Tong, R., Zou, L., Song, G., Cho, W. C."MicroRNAs in diffuse large B‑cell lymphoma (Review)". Oncology Letters 11.2 (2016): 1271-1280.
Chicago
Ni, H., Tong, R., Zou, L., Song, G., Cho, W. C."MicroRNAs in diffuse large B‑cell lymphoma (Review)". Oncology Letters 11, no. 2 (2016): 1271-1280. https://doi.org/10.3892/ol.2015.4064
Copy and paste a formatted citation
x
Spandidos Publications style
Ni H, Tong R, Zou L, Song G and Cho WC: MicroRNAs in diffuse large B‑cell lymphoma (Review). Oncol Lett 11: 1271-1280, 2016.
APA
Ni, H., Tong, R., Zou, L., Song, G., & Cho, W.C. (2016). MicroRNAs in diffuse large B‑cell lymphoma (Review). Oncology Letters, 11, 1271-1280. https://doi.org/10.3892/ol.2015.4064
MLA
Ni, H., Tong, R., Zou, L., Song, G., Cho, W. C."MicroRNAs in diffuse large B‑cell lymphoma (Review)". Oncology Letters 11.2 (2016): 1271-1280.
Chicago
Ni, H., Tong, R., Zou, L., Song, G., Cho, W. C."MicroRNAs in diffuse large B‑cell lymphoma (Review)". Oncology Letters 11, no. 2 (2016): 1271-1280. https://doi.org/10.3892/ol.2015.4064
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