Diffuse large B-cell lymphoma in colon confounded by prior history of colorectal cancer: A case report and literature review

Ren,Yanling; Chen,Zhilu; Su,Chuanyong; Tong,Hongyan; Qian,Wenbin

doi:10.3892/ol.2016.4078

February-2016 Volume 11 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2016 Volume 11 Issue 2

Full Size Image

Case Report

Diffuse large B-cell lymphoma in colon confounded by prior history of colorectal cancer: A case report and literature review

Authors:
- Yanling Ren
- Zhilu Chen
- Chuanyong Su
- Hongyan Tong
- Wenbin Qian
View Affiliations / Copyright

Affiliations: Department of Hematology, The First Affiliated Hospital of Zhejiang University, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Hematology, Tongde Hospital of Zhejiang, Hangzhou, Zhejiang 310012, P.R. China
Pages: 1493-1495
|
Published online on: January 7, 2016

https://doi.org/10.3892/ol.2016.4078
Expand metrics +

Abstract

A 66-year-old male underwent left hemicolectomy for rectal adenocarcinoma in 2008. Five years later he was admitted to hospital with abdominal pain. A computed tomography scan revealed notable thickening of the middle of the ascending colon wall, and colonoscopy revealed an ulcerofungating mass of 3x3 cm in the cecum and extending to the ascending colon. Under the consideration of cancer recurrence, laparoscopic right hemicolectomy was performed directly. Surgical specimens revealed sheets of large pleomorphic lymphoid cells with nuclei of different sizes, nucleoli and mitotic phases visible in most cells. These tested positive for CD45, CD20 and CD79a diffusely, but negative for CD3, CD5, Bcl‑2, Bcl‑6 and ALK. The Ki‑67 proliferation index was 40%. Epstein‑Barr virus in situ hybridization did not reveal any positive signals in any of the tumor cells. Based on these findings, the recurrent tumor was diagnosed as diffuse large B‑cell lymphoma. The patient could have avoided surgery and received chemotherapy only; however, the case was confounded by the patient's prior history of colorectal cancer due to the rarity of colon lymphoma following rectal cancer in the same patient. It is therefore essential to investigate carefully and differentiate between potential lesions during routine postoperative colonoscopy following colorectal cancer surgery, as patients may present with rare colon lymphoma, which may be confused with a recurrence of colorectal cancer.

View Figures

View References

1	Morton LM, Swerdlow AJ, Schaapveld M, Ramadan S, Hodgson DC, Radford J and van Leeuwen FE: Current knowledge and future research directions in treatment-related second primary malignancies. EJC Suppl. 12:5–17. 2014. View Article : Google Scholar : PubMed/NCBI
2	Ueno M, Muto T, Oya M, Ota H, Azekura K and Yamaguchi T: Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol. 8:162–167. 2003. View Article : Google Scholar : PubMed/NCBI
3	Cooperberg MR and Fiedler PN: Ki-1 anaplastic large-cell lymphoma occurring at the site of ileocolonic anastomosis in a patient treated surgically for colonic adenocarcinoma: case report and review of the literature. Ann Diagn Pathol. 5:162–167. 2001. View Article : Google Scholar : PubMed/NCBI
4	Dionigi G, Annoni M, Rovera F, Boni L, Villa F, Castano P, Bianchi V and Dionigi R: Primary colorectal lymphomas: review of the literature. Surg Oncol. 16(Suppl 1): S169–S171. 2007. View Article : Google Scholar : PubMed/NCBI
5	Stanojevic GZ, Nestorovic MD, Brankovic BR, Stojanovic MP, Jovanovic MM and Radojkovic MD: Primary colorectal lymphoma: an overview. World J Gastrointest Oncol. 3:14–18. 2011. View Article : Google Scholar : PubMed/NCBI
6	Ikeda J, Yamauchi A, Hoshida Y, Okamura S, Hashimoto K, Aozasa K and Morii E: Peripheral T-cell lymphoma developing at ileocolonic anastomosis site after colectomy for adenocarcinoma. Pathol Res Pract. 206:376–378. 2010. View Article : Google Scholar : PubMed/NCBI
7	Liao MT, Cheng MF, Chang WC, Wu YC, Lee HS and Tsai SH: Duodenal mantle cell lymphoma in a patient with advanced sigmoid adenocarcinoma. South Med J. 102:429–431. 2009. View Article : Google Scholar : PubMed/NCBI
8	Shaheen S and Guddati AK: Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon. Med Oncol. 30:5022013. View Article : Google Scholar : PubMed/NCBI
9	Cui Y, Liu T, Zhou Y, Ji Y, Hou Y, Jin W and Feng Y: Five cases report of solid tumor synchronously with hematologic malignancy. Cancer Res Treat. 44:63–68. 2012. View Article : Google Scholar : PubMed/NCBI
10	Gonzalez QH, Heslin MJ, Dávila-Cervantes A, Alvarez-Tostado J, de los Monteros AE, Shore G and Vickers P: Primary colonic lymphoma. Am Surg. 74:214–216. 2008.PubMed/NCBI
11	Myung SJ, Joo KR, Yang SK, Jung HY, Chang HS, Lee HJ, Hong WS, Kim JH, Min YI, Kim HC, et al: Clinicopathologic features of ileocolonic malignant lymphoma: analysis according to colonoscopic classification. Gastrointest Endosc. 57:343–347. 2003. View Article : Google Scholar : PubMed/NCBI
12	Salar A, Domingo-Domenech E, Estany C, Canales MA, Gallardo F, Servitje O, Fraile G and Montalbán C: Combination therapy with rituximab and intravenous or oral fludarabine in the first-line, systemic treatment of patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type. Cancer. 115:5210–5217. 2009. View Article : Google Scholar : PubMed/NCBI
13	Bairey O, Ruchlemer R and Shpilberg O: Non-Hodgkin's lymphomas of the colon. Isr Med Assoc J. 8:832–835. 2006.PubMed/NCBI
14	Huang S, Zheng ZX, Xu Q and Yuan XH: Diagnosis and treatment of primary colorectal non-Hodgkin's lymphoma: Analysis of 52 cases. Zhonghua Zhong Liu Za Zhi. 35:305–308. 2013.(In Chinese). PubMed/NCBI
15	Pascual M, Sánchez-González B, García M, Pera M and Grande L: Primary lymphoma of the colon. Rev Esp Enferm Dig. 105:74–78. 2013. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diffuse large B-cell lymphoma in colon confounded by prior history of colorectal cancer: A case report and literature review

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles