Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: A case report and review of the literature

Huang,Yu‑Hua; Tian,Yu‑Feng; Li,Chien‑Feng

doi:10.3892/ol.2016.4082

February-2016 Volume 11 Issue 2

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February-2016 Volume 11 Issue 2

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Case Report

Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: A case report and review of the literature

Authors:
- Yu‑Hua Huang
- Yu‑Feng Tian
- Chien‑Feng Li
View Affiliations / Copyright

Affiliations: Department of Pathology, Chi‑Mei Medical Center, Tainan 710, Taiwan, R.O.C., Department of General Surgery, Chi‑Mei Medical Center, Tainan 710, Taiwan, R.O.C.
Pages: 1429-1434
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Published online on: January 7, 2016

https://doi.org/10.3892/ol.2016.4082
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Abstract

Here, we present an uncommon case of inflammatory myofibroblastic tumor (IMT) involving the mesentery. The tumor was composed of loosely arranged round‑to‑spindle‑shaped tumor cells with amphophilic cytoplasm in an inflammatory and myxoid background. The mitotic activity was low (1 per 50 high‑power fields) and the tumor cells lacked cellular atypism. Immunohistochemically, the tumor cells demonstrated strong nuclear membranous staining with anaplastic lymphoma kinase (ALK). In situ hybridization for ALK gene rearrangement revealed a splitting apart of the two signals within the tumor cells. Reverse transcription‑polymerase chain reaction revealed that the tumor harbored a ran‑binding protein 2 (RANBP2)‑ALK rearrangement. IMTs are usually characterized by epithelioid‑to‑round cells featuring increased mitotic activity, occasionally demonstrating unusual tumor cells and more aggressive clinical behavior. To date, 23 IMTs have been reported with RANBP2 and ALK gene rearrangements. However, the present case demonstrated indolent cytological features, leading to a difficulty in differentiating it from desmoid-type fibromatosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement with bland cytological features mimicking desmoid-type fibromatosis: A case report and review of the literature

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