Primary dumbbell-shaped epidural myxoid liposarcoma of the thoracic spine: A case report and review of the literature

Kaneuchi,Yoichi; Hakozaki,Michiyuki; Yamada,Hitoshi; Tajino,Takahiro; Watanabe,Kazuyuki; Otani,Koji; Hojo,Hiroshi; Hasegawa,Tadashi; Konno,Shinichi

doi:10.3892/ol.2016.4089

Primary dumbbell-shaped epidural myxoid liposarcoma of the thoracic spine: A case report and review of the literature

Authors:
- Yoichi Kaneuchi
- Michiyuki Hakozaki
- Hitoshi Yamada
- Takahiro Tajino
- Kazuyuki Watanabe
- Koji Otani
- Hiroshi Hojo
- Tadashi Hasegawa
- Shinichi Konno
View Affiliations

Affiliations: Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Diagnostic Pathology, Aizu Medical Center, Fukushima Medical University, Fukushima 969‑3492, Japan, Department of Surgical Pathology, Sapporo Medical University School of Medicine, Hokkaido 060‑8453, Japan
Published online on: January 8, 2016 https://doi.org/10.3892/ol.2016.4089
Pages: 1421-1424

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Myxoid liposarcoma frequently occurs in the deep soft tissue of the extremities, particularly in the thigh. The present study describes an extremely rare case of primary dumbbell-shaped epidural myxoid liposarcoma of the thoracic spine occurring in a 22‑year‑old woman. Although preoperative magnetic resonance imaging findings were thought to be compatible with schwannoma, the pathological diagnosis of the resected tumor was myxoid liposarcoma. The patient underwent three courses of adjuvant chemotherapy with doxorubicin and ifosfamide, and exhibited no symptoms or signs of local recurrence or metastasis for 18 months post surgery. The present case suggests that, when radiologically diagnosing spinal epidural tumors, clinicians should consider the possibility of myxoid liposarcoma.

View Figures

View References

1	Antonescu CR and Ladanyi M: Myxoid liposarcoma. WHO Classification of Tumours of Soft Tissue and Bone (4th). Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: International Agency for Research on Cancer. (Lyon, France). 39–41. 2013.
2	Kirollos R, Koutsoubelis G, Ross S and Al Sarraj S: An unusual case of spinal metastasis from a liposarcoma. Eur J Surg Oncol. 22:303–305. 1996. View Article : Google Scholar : PubMed/NCBI
3	Sung MS, Kang HS, Suh JS, Lee JH, Park JM, Kim JY and Lee HG: Myxoid liposarcoma: Appearance at MR imaging with histologic correlation. Radiographics. 20:1007–1019. 2000. View Article : Google Scholar : PubMed/NCBI
4	Turanli S, Ozer H, Ozyurekoglu T and Cakiroglu E: Liposarcoma in the epidural space. Spine. 25:1733–1735. 2000. View Article : Google Scholar : PubMed/NCBI
5	Katz D, Boonsirikamchai P, Choi H, Lazar AJ, Wang WL, Xiao L, Park MS, Ravi V, Benjamin RS and Araujo DM: Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma. Clin Sarcoma Res. 2:22012. View Article : Google Scholar : PubMed/NCBI
6	Chung PW, Deheshi BM, Ferguson PC, Wunder JS, Griffin AM, Catton CN, Bell RS, White LM, Kandel RA and O'Sullivan B: Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: A comparison with other soft tissue sarcomas. Cancer. 115:3254–3261. 2009. View Article : Google Scholar : PubMed/NCBI
7	Coindre JM: Grading and staging of sarcomas. WHO Classification of Tumours of Soft Tissue and Bone (4th). Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: (Lyon, France). International Agency for Research on Cancer. 17–18. 2013.
8	Ogose A, Hotta T, Inoue Y, Sakata S, Takano R and Yamamura S: Myxoid liposarcoma metastatic to the thoracic epidural space without bone involvement: Report of two cases. Jpn J Clin Oncol. 31:447–449. 2001. View Article : Google Scholar : PubMed/NCBI
9	Lee SY, Kim HJ, Park SY, Park SH and Chung SK: Myxoid liposarcoma involving the liver, subcutaneous tissue and epidural space in a polycystic disease patient. Clin Nucl Med. 33:507–509. 2008. View Article : Google Scholar : PubMed/NCBI
10	Kobayashi H, Kotoura Y, Sakahara H, Hosono M, Hosono M, Tsaboyama T, Yamamuro T, Endo K and Konishi J: Schwannoma of the extremities: Comparison of MRI and pentavalent Technetium-99m-Dimercaptosuccinic acid and Gallium-67-citrate scintigraphy. J Nucl Med. 35:1174–1178. 1994.PubMed/NCBI
11	Liu Y, Chen X, Wang T and Wang Z: Imaging observations of a schwannoma of low malignant potential in the anterior abdominal wall: A case report. Oncol Lett. 8:1159–1162. 2014.PubMed/NCBI
12	Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ and Malawer MM: Liposarcoma of the extremities: MR and CT findings in the histological subtypes. Radiology. 186:455–459. 1993. View Article : Google Scholar : PubMed/NCBI
13	Sundaram M, Baran G, Merenda G and McDonald DJ: Myxoid liposarcoma: Magnetic resonance imaging appearances with clinical and histological correlation. Skeletal Radiol. 19:359–362. 1990. View Article : Google Scholar : PubMed/NCBI
14	De Verdelhan O, Haegelen C, Carsin-Nicol B, Riffaud L, Amlashi SF, Brassier G, Carsin M and Morandi P: MR imaging feature of spinal schwannomas and meningiomas. J Neuroradiol. 32:42–49. 2005. View Article : Google Scholar : PubMed/NCBI
15	Hirano K, Imagama S, Sato K, Kato F, Yukawa Y, Yoshihara H, Kamiya M, Deguchi M, Kanemura T, Matsubara Y, et al: Primary spinal cord tumors: Review of 678 surgically treated patients in Japan. A multicenter study. Eur Spine J. 21:2019–2026. 2012. View Article : Google Scholar : PubMed/NCBI
16	Ozawa H, Kokubun S, Aizawa T, Hoshikawa T and Kawahara C: Spinal dumbbell tumors: An analysis of a series of 118 cases. J Neurosurg Spine. 7:587–593. 2007. View Article : Google Scholar : PubMed/NCBI
17	Brenner W, Eary JF, Hwang W, Vernon C and Conrad EU: Risk assessment in liposarcoma patients based on FDG PET imaging. Eur J Nucl Med Mol Imaging. 33:1290–1295. 2006. View Article : Google Scholar : PubMed/NCBI
18	Guadagnolo BA, Zagars GK, Ballo MT, Patel SR, Lewis VO, Benjamin RS and Pollock RE: Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 70:760–765. 2008. View Article : Google Scholar : PubMed/NCBI