Open Access

Usefulness of PET/CT in the diagnosis of recurrent or metastasized differentiated thyroid carcinoma

  • Authors:
    • Cun‑Zhi Lu
    • Su‑Sheng Cao
    • Wei Wang
    • Jun Liu
    • Ning Fu
    • Feng Lu
  • View Affiliations

  • Published online on: February 15, 2016     https://doi.org/10.3892/ol.2016.4229
  • Pages: 2420-2423
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative findings on the 131I-diagnostic whole-body scanning (dWBS). Fifteen patients with DTC, abnormal thyroglobulin levels, and negative 131I‑dWBS findings were scanned using the 18F‑FDG PET/CT. Positive diagnosis was based on postoperative histologic findings, and clinical and imaging follow‑up results obtained in the subsequent 6 months. In addition, preoperative and postoperative thyroglobulin levels were compared. Using the findings of 18F‑FDG PET/CT and data on confirmed positive diagnosis, sensitivity and positive predictive value (PPV) were calculated. Sensitivity and PPV of PET/CT in detecting recurrence or metastasisization of DTC were 93.30 and 91.40%, respectively. Furthermore, postoperative thyroglobulin levels were markedly lower compared to the preoperative levels (respectively, 4.67±1.71 vs. 58.53±18.34 ng/ml; p<0.05). PET/CT scan with 18F‑FDG is an informative technique for the detection of recurrent or metastasized DTC in patients with abnormal thyroglobulin levels and negative 131I-dWBS findings.
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April-2016
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Spandidos Publications style
Lu CZ, Cao SS, Wang W, Liu J, Fu N and Lu F: Usefulness of PET/CT in the diagnosis of recurrent or metastasized differentiated thyroid carcinoma. Oncol Lett 11: 2420-2423, 2016
APA
Lu, C., Cao, S., Wang, W., Liu, J., Fu, N., & Lu, F. (2016). Usefulness of PET/CT in the diagnosis of recurrent or metastasized differentiated thyroid carcinoma. Oncology Letters, 11, 2420-2423. https://doi.org/10.3892/ol.2016.4229
MLA
Lu, C., Cao, S., Wang, W., Liu, J., Fu, N., Lu, F."Usefulness of PET/CT in the diagnosis of recurrent or metastasized differentiated thyroid carcinoma". Oncology Letters 11.4 (2016): 2420-2423.
Chicago
Lu, C., Cao, S., Wang, W., Liu, J., Fu, N., Lu, F."Usefulness of PET/CT in the diagnosis of recurrent or metastasized differentiated thyroid carcinoma". Oncology Letters 11, no. 4 (2016): 2420-2423. https://doi.org/10.3892/ol.2016.4229