B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature

  • Authors:
    • Hong‑Hu Zhu
    • Xiao‑Su Zhao
    • Ya‑Zhen Qin
    • Yue‑Yun Lai
    • Hao Jiang
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  • Published online on: February 23, 2016     https://doi.org/10.3892/ol.2016.4260
  • Pages: 2644-2650
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Abstract

The SET nuclear proto-oncogene (SET)-nucleoporin (NUP)214 fusion gene, which results from cryptic t(9;9)(q34;q34) or del(9)(q34.11q34.13), is a rare genetic event in hematological malignancies. The majority of patients carrying SET‑NUP214 experience T-cell acute lymphoblastic leukemia (T-ALL), but rarely experience acute undifferentiated leukemia or acute myeloid leukemia. The current study presents the case of a 19‑year‑old male patient with B‑cell ALL (B‑ALL) carrying the SET‑NUP214 fusion gene, in addition to an fms‑related tyrosine kinase 3‑internal tandem duplication mutation and a complex karyotype abnormality. The patient exhibited chemotherapy resistance. To the best of our knowledge, the present study is the first report of a case of B‑ALL carrying the SET‑NUP214 fusion gene, and provides a review of the literature.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhu HH, Zhao XS, Qin YZ, Lai YY and Jiang H: B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature. Oncol Lett 11: 2644-2650, 2016
APA
Zhu, H., Zhao, X., Qin, Y., Lai, Y., & Jiang, H. (2016). B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature. Oncology Letters, 11, 2644-2650. https://doi.org/10.3892/ol.2016.4260
MLA
Zhu, H., Zhao, X., Qin, Y., Lai, Y., Jiang, H."B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature". Oncology Letters 11.4 (2016): 2644-2650.
Chicago
Zhu, H., Zhao, X., Qin, Y., Lai, Y., Jiang, H."B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature". Oncology Letters 11, no. 4 (2016): 2644-2650. https://doi.org/10.3892/ol.2016.4260