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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2016 Volume 11 Issue 4

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report

  • Authors:
    • Guo‑Ning Fu
    • Hai‑Ying Fan
    • Xue‑Jing Han
    • Chun‑Lei Xin

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
  • Pages: 2651-2653
    |
    Published online on: February 24, 2016
       https://doi.org/10.3892/ol.2016.4275
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Abstract

The typical breakpoint cluster region/Abelson (BCR-ABL) fusion gene, which is located in the Philadelphia chromosome, in association with a complex translocation event is only observed in 2‑10% of patients with chronic myelogenous leukemia (CML). CML is diagnosed based on the presence of splenomegaly, increased peripheral white blood cells and the expression of BCR‑ABL. The present study reports the case of a patient with CML that possessed complex aberrations involving 5 chromosome translocations, which consisted of t(1;6)(p36.1;q25) and t(9;22;11)(q34;q11.2;q11). After 2 months of follow‑up, the patient is in remission following treatment with imatinib (400 mg/day) and hydroxyurea (3,000 mg/day). The hematological parameters of the patient were significantly improved and the white blood cell count returned to normal (from 361.00x109 cells/l to 6.83x109 cells/l; normal range, 3.50‑9.50x109 cells/l). The results of the ultrasonic examination revealed that the presence of splenomegaly had disappeared, indicating that the treatment strategy was effective. According to the outcome of the treatment, hydroxyurea in combination with imatinib is recommended for use in similar cases of CML.
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Copy and paste a formatted citation
Spandidos Publications style
Fu GN, Fan HY, Han XJ and Xin CL: Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report. Oncol Lett 11: 2651-2653, 2016.
APA
Fu, G., Fan, H., Han, X., & Xin, C. (2016). Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report. Oncology Letters, 11, 2651-2653. https://doi.org/10.3892/ol.2016.4275
MLA
Fu, G., Fan, H., Han, X., Xin, C."Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report". Oncology Letters 11.4 (2016): 2651-2653.
Chicago
Fu, G., Fan, H., Han, X., Xin, C."Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report". Oncology Letters 11, no. 4 (2016): 2651-2653. https://doi.org/10.3892/ol.2016.4275
Copy and paste a formatted citation
x
Spandidos Publications style
Fu GN, Fan HY, Han XJ and Xin CL: Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report. Oncol Lett 11: 2651-2653, 2016.
APA
Fu, G., Fan, H., Han, X., & Xin, C. (2016). Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report. Oncology Letters, 11, 2651-2653. https://doi.org/10.3892/ol.2016.4275
MLA
Fu, G., Fan, H., Han, X., Xin, C."Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report". Oncology Letters 11.4 (2016): 2651-2653.
Chicago
Fu, G., Fan, H., Han, X., Xin, C."Complex chromosomal rearrangements involving five chromosomes in chronic myelogenous leukemia: A case report". Oncology Letters 11, no. 4 (2016): 2651-2653. https://doi.org/10.3892/ol.2016.4275
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