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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2016 Volume 11 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver

  • Authors:
    • Jung‑Hye Choi
    • Young‑Woong Won
    • Hyun Sung Kim
    • Young‑Ha Oh
    • Sanghyeok Lim
    • Han‑Joon Kim
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Gyeonggi 471‑701, Republic of Korea, Department of Pathology, Hanyang University Guri Hospital, Guri, Gyeonggi 471‑701, Republic of Korea, Department of Radiology, Hanyang University Guri Hospital, Guri, Gyeonggi 471‑701, Republic of Korea, Department of Surgery, Hanyang University Guri Hospital, Guri, Gyeonggi 471‑701, Republic of Korea
  • Pages: 2861-2864
    |
    Published online on: February 29, 2016
       https://doi.org/10.3892/ol.2016.4286
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Abstract

Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer; however, it may cause liver injury, particularly sinusoidal obstruction syndrome (SOS). Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. An abdominal computed tomography revealed a novel 1 cm, low-density lesion in segment 1 of the liver following the administration of the fourth round of oxaliplatin‑based adjuvant chemotherapy for stage III colon cancer. Since the lesion was indistinguishable from metastasis, even with detailed imaging studies, including magnetic resonance imaging and positron emission tomography‑computed tomography, an isolated caudate lobectomy was planned. The cut surface of the resected liver showed a localized reddish congested lesion measuring 1.4 cm in diameter. The adjacent hepatic parenchyma also demonstrated diffuse sinusoidal congestion with a nutmeg‑like appearance. Histologically, the lesion exhibited severe sinusoidal congestion with peliosis hepatis-like features. The widened sinusoidal space was outlined by markedly attenuated hepatic cords and filled with erythrocytes. The final diagnosis was oxaliplatin‑induced SOS. The patient recovered completely and was relapse‑free at the time of writing.
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Copy and paste a formatted citation
Spandidos Publications style
Choi JH, Won YW, Kim HS, Oh YH, Lim S and Kim HJ: Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver. Oncol Lett 11: 2861-2864, 2016.
APA
Choi, J., Won, Y., Kim, H.S., Oh, Y., Lim, S., & Kim, H. (2016). Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver. Oncology Letters, 11, 2861-2864. https://doi.org/10.3892/ol.2016.4286
MLA
Choi, J., Won, Y., Kim, H. S., Oh, Y., Lim, S., Kim, H."Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver". Oncology Letters 11.4 (2016): 2861-2864.
Chicago
Choi, J., Won, Y., Kim, H. S., Oh, Y., Lim, S., Kim, H."Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver". Oncology Letters 11, no. 4 (2016): 2861-2864. https://doi.org/10.3892/ol.2016.4286
Copy and paste a formatted citation
x
Spandidos Publications style
Choi JH, Won YW, Kim HS, Oh YH, Lim S and Kim HJ: Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver. Oncol Lett 11: 2861-2864, 2016.
APA
Choi, J., Won, Y., Kim, H.S., Oh, Y., Lim, S., & Kim, H. (2016). Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver. Oncology Letters, 11, 2861-2864. https://doi.org/10.3892/ol.2016.4286
MLA
Choi, J., Won, Y., Kim, H. S., Oh, Y., Lim, S., Kim, H."Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver". Oncology Letters 11.4 (2016): 2861-2864.
Chicago
Choi, J., Won, Y., Kim, H. S., Oh, Y., Lim, S., Kim, H."Oxaliplatin-induced sinusoidal obstruction syndrome mimicking metastatic colon cancer in the liver". Oncology Letters 11, no. 4 (2016): 2861-2864. https://doi.org/10.3892/ol.2016.4286
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