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Case Report

Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review

  • Authors:
    • Zheng‑Lei Shen
    • Lie‑Fen Yin
    • Wen‑Wen Mao
    • Jin Liang
    • Ling Yang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Yunnan Tumor Hospital, Kunming, Yunnan 650118, P.R. China, Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China, Department of Geriatrics, Kunming Second People's Hospital, Kunming, Yunnan 650204, P.R. China
  • Pages: 2909-2912
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/ol.2016.4304
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Abstract

The current study reports the case of a patient with Philadelphia chromosome-negative (Ph-) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) that also possessed characteristic enlarged lymph nodes. A lymph node biopsy resulted in the diagnosis of CP-CML, in addition to T-lymphoblastic cell NHL with negative break point cluster/Abelson tyrosine kinase fusion genes in the lymph node of the patient, which was diagnosed as Ph‑ NHL. A review of the literature was performed in the present study to investigate the genetic differences between Ph‑ NHL and Ph+ NHL in patients with CML. The median age of patients with NHL and CML was 41 years. The follow‑up time of patients with Ph+ NHL was significantly shorter (mean, <6 months) compared to the follow‑up time of patients with Ph‑ NHL (mean, >15 months). Therefore the present study concludes that Ph+ NHL may be more aggressive compared with Ph+ NHL. The present study suggests that additional studies are required to assess the clinical and genetic characteristics of NHL patients with CML.
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Copy and paste a formatted citation
Spandidos Publications style
Shen ZL, Yin LF, Mao WW, Liang J and Yang L: Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncol Lett 11: 2909-2912, 2016.
APA
Shen, Z., Yin, L., Mao, W., Liang, J., & Yang, L. (2016). Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncology Letters, 11, 2909-2912. https://doi.org/10.3892/ol.2016.4304
MLA
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11.4 (2016): 2909-2912.
Chicago
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11, no. 4 (2016): 2909-2912. https://doi.org/10.3892/ol.2016.4304
Copy and paste a formatted citation
x
Spandidos Publications style
Shen ZL, Yin LF, Mao WW, Liang J and Yang L: Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncol Lett 11: 2909-2912, 2016.
APA
Shen, Z., Yin, L., Mao, W., Liang, J., & Yang, L. (2016). Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncology Letters, 11, 2909-2912. https://doi.org/10.3892/ol.2016.4304
MLA
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11.4 (2016): 2909-2912.
Chicago
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11, no. 4 (2016): 2909-2912. https://doi.org/10.3892/ol.2016.4304
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