Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review

  • Authors:
    • Zheng‑Lei Shen
    • Lie‑Fen Yin
    • Wen‑Wen Mao
    • Jin Liang
    • Ling Yang
  • View Affiliations

  • Published online on: March 7, 2016     https://doi.org/10.3892/ol.2016.4304
  • Pages: 2909-2912
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Abstract

The current study reports the case of a patient with Philadelphia chromosome-negative (Ph-) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) that also possessed characteristic enlarged lymph nodes. A lymph node biopsy resulted in the diagnosis of CP-CML, in addition to T-lymphoblastic cell NHL with negative break point cluster/Abelson tyrosine kinase fusion genes in the lymph node of the patient, which was diagnosed as Ph‑ NHL. A review of the literature was performed in the present study to investigate the genetic differences between Ph‑ NHL and Ph+ NHL in patients with CML. The median age of patients with NHL and CML was 41 years. The follow‑up time of patients with Ph+ NHL was significantly shorter (mean, <6 months) compared to the follow‑up time of patients with Ph‑ NHL (mean, >15 months). Therefore the present study concludes that Ph+ NHL may be more aggressive compared with Ph+ NHL. The present study suggests that additional studies are required to assess the clinical and genetic characteristics of NHL patients with CML.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shen ZL, Yin LF, Mao WW, Liang J and Yang L: Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncol Lett 11: 2909-2912, 2016
APA
Shen, Z., Yin, L., Mao, W., Liang, J., & Yang, L. (2016). Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review. Oncology Letters, 11, 2909-2912. https://doi.org/10.3892/ol.2016.4304
MLA
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11.4 (2016): 2909-2912.
Chicago
Shen, Z., Yin, L., Mao, W., Liang, J., Yang, L."Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review". Oncology Letters 11, no. 4 (2016): 2909-2912. https://doi.org/10.3892/ol.2016.4304