Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 11 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Metformin use and young age lung cancer: A case series report

  • Authors:
    • Bo Deng
    • Yi Wang
    • Dong Xie
    • Shawn M. Stoddard
    • Ping Yang
  • View Affiliations / Copyright

    Affiliations: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
  • Pages: 2899-2902
    |
    Published online on: March 8, 2016
       https://doi.org/10.3892/ol.2016.4307
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Metformin, a widely-prescribed antihyperglycemic drug for the treatment of diabetes mellitus type 2 (DM-II), has been demonstrated to be antineoplastic in vivo and in vitro. However, various preclinical and epidemiological studies investigating the effects of metformin on lung cancer have obtained inconclusive results. The aim of the present study was to retrospectively investigate the effects of metformin, for the treatment of diabetes mellitus type 2 (DM‑II), on the onset of lung cancer. In the present study, the pathological features of ten consecutive young age lung cancer cases, aged between 15 and 45 years old at the time of diagnosis and exhibiting existing primary DM, were investigated using the Mayo Clinic Lung Cancer Cohort database. Amongst this cohort, there were 2 cases of DM type 1 (DM‑I) and 8 cases of DM‑II. Of these patients, two exhibiting adenocarcinoma and DM‑II had not been administered metformin; however, 1 patient exhibiting lymphoma and 4 patients with pulmonary neuroendocrine tumors (NETs) had been administered metformin at least 12 months prior to lung cancer diagnosis. The remaining 3 patients exhibiting NETs and DM‑II had been treated with insulin therapy. The present study hypothesized that the high proportion of NETs observed in the cases of metformin‑treated DM‑II was unlikely to be a random event. It was suggested that metformin treatment was not effective in the prevention of pulmonary NETs, and that metformin may instead induce the occurrence of NETs via as yet unknown signaling pathways. The present hypothesis may potentially serve as a novel indicator for the requirement to monitor young patients with diabetes, who are being treated with metformin, for the occurrence of pulmonary NETs.
View Figures

Figure 1

View References

1 

Wang Y, Dai W, Chu X, Yang B, Zhao M and Sun Y: Metformin inhibits lung cancer cells proliferation through repressing microRNA-222. Biotechnol Lett. 35:2013–2019. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Col NF, Ochs L, Springmann V, Aragaki AK and Chlebowski RT: Metformin and breast cancer risk: A meta-analysis and critical literature review. Breast Cancer Res Treat. 135:639–646. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Currie CJ, Poole CD and Gale EA: The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 52:1766–1777. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Wright JL and Stanford JL: Metformin use and prostate cancer in Caucasian men: Results from a population-based case-control study. Cancer Causes Control. 20:1617–1622. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Memmott RM, Mercado JR, Maier CR, Kawabata S, Fox SD and Dennis PA: Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila). 3:1066–1076. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Smiechowski BB, Azoulay L, Yin H, Pollak MN and Suissa S: The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care. 36:124–129. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Nie SP, Chen H, Zhuang MQ and Lu M: Anti-diabetic medications do not influence risk of lung cancer in patients with diabetes mellitus: A systematic review and meta-analysis. Asian Pac J Cancer Prev. 15:6863–6869. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Thomas A, Chen Y, Yu T, Jakopovic M and Giaccone G: Trends and characteristics of young non-small cell lung cancer patients in the United States. Front Oncol. 5:1132015. View Article : Google Scholar : PubMed/NCBI

9 

Liu M, Cai X, Yu W, Lv C and Fu X: Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: A population-based study. Oncotarget. Oct 26–2015.(Epub ahead of print).

10 

Pinhas-Hamiel O and Zeitler P: Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes. 8(Suppl 9): 16–27. 2007. View Article : Google Scholar : PubMed/NCBI

11 

National Institute for Health and Care Excellence: Diabetes (type 1 and type 2) in children and young people: Diagnosis and management. London, UK: 2015.http://www.nice.org.uk/guidance/ng18/resources/diabetes-type-1-and-type-2-in-children-and-young-people-diagnosis-and-management-1837278149317Accessed. February 05–2015

12 

Sakoda LC, Ferrara A, Achacoso NS, Peng T, Ehrlich SF, Quesenberry CP Jr and Habel LA: Metformin use and lung cancer risk in patients with diabetes. Cancer Prev Res (Phila). 8:174–179. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Mack JW, Cronin A, Fasciano K, Block SD and Keating NL: Cancer treatment decision-making among young adults with lung and colorectal cancer: A comparison with adults in middle age. Psychooncology. Sep 2–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

14 

Skuladottir H, Hirsch FR, Hansen HH and Olsen JH: Pulmonary neuroendocrine tumors: Incidence and prognosis of histological subtypes. A population-based study in Denmark. Lung Cancer. 37:127–135. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Sun Z, Aubry MC, Deschamps C, et al: Histologic grade is an independent prognostic factor for survival in non-small cell lung cancer: An analysis of 5018 hospital- and 712 population-based cases. J Thorac Cardiovasc Surg. 131:1014–1020. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Jatoi A, Qi Y, Wampfler JA, Busta AJ, Yang P and Mandrekar S: The purported effects of alcohol on appetite and weight in lung cancer patients. Nutr Cancer. 63:1251–1255. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Deng B, Cassivi SD, de Andrade M, et al: Clinical outcomes and changes in lung function after segmentectomy versus lobectomy for lung cancer cases. J Thorac Cardiovasc Surg. 148:1186–1192. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Yang P, Cheville AL, Wampfler JA, Garces YI, Jatoi A, Clark MM, Cassivi SD, Midthun DE, Marks RS, Aubry MC, et al: Quality of life and symptom burden among long-term lung cancer survivors. J Thorac Oncol. 7:64–70. 2012. View Article : Google Scholar : PubMed/NCBI

19 

O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, et al: mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 66:1500–1508. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: American Joint Committee on Cancer: AJCC Cancer Staging Manual. Springer. New York: 2010.

21 

Libutti SK: Therapy: Blockade of IGF-1R - not effective in neuroendocrine tumours. Nat Rev Endocrinol. 9:389–390. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Vlotides G, Tanyeri A, Spampatti M, Zitzmann K, Chourdakis M, Spttl C, Maurer J, Nölting S, Göke B and Auernhammer CJ: Anticancer effects of metformin on neuroendocrine tumor cells in vitro. Hormones. 13:498–508. 2014.PubMed/NCBI

23 

Gallagher EJ and LeRoith D: Obesity and diabetes: The increased risk of cancer and cancer-related mortality. Physiol Rev. 95:727–748. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Tseng CH: Diabetes but not insulin increases the risk of lung cancer: A Taiwanese population-based study. PLoS One. 9:e1015532014. View Article : Google Scholar : PubMed/NCBI

25 

Maxwell JE, O'Dorisio TM, Bellizzi AM and Howe JR: Elevated pancreatic polypeptide levels in pancreatic neuroendocrine tumors and diabetes mellitus: Causation or association? Pancreas. 43:651–656. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng B, Wang Y, Xie D, Stoddard SM and Yang P: Metformin use and young age lung cancer: A case series report. Oncol Lett 11: 2899-2902, 2016.
APA
Deng, B., Wang, Y., Xie, D., Stoddard, S.M., & Yang, P. (2016). Metformin use and young age lung cancer: A case series report. Oncology Letters, 11, 2899-2902. https://doi.org/10.3892/ol.2016.4307
MLA
Deng, B., Wang, Y., Xie, D., Stoddard, S. M., Yang, P."Metformin use and young age lung cancer: A case series report". Oncology Letters 11.4 (2016): 2899-2902.
Chicago
Deng, B., Wang, Y., Xie, D., Stoddard, S. M., Yang, P."Metformin use and young age lung cancer: A case series report". Oncology Letters 11, no. 4 (2016): 2899-2902. https://doi.org/10.3892/ol.2016.4307
Copy and paste a formatted citation
x
Spandidos Publications style
Deng B, Wang Y, Xie D, Stoddard SM and Yang P: Metformin use and young age lung cancer: A case series report. Oncol Lett 11: 2899-2902, 2016.
APA
Deng, B., Wang, Y., Xie, D., Stoddard, S.M., & Yang, P. (2016). Metformin use and young age lung cancer: A case series report. Oncology Letters, 11, 2899-2902. https://doi.org/10.3892/ol.2016.4307
MLA
Deng, B., Wang, Y., Xie, D., Stoddard, S. M., Yang, P."Metformin use and young age lung cancer: A case series report". Oncology Letters 11.4 (2016): 2899-2902.
Chicago
Deng, B., Wang, Y., Xie, D., Stoddard, S. M., Yang, P."Metformin use and young age lung cancer: A case series report". Oncology Letters 11, no. 4 (2016): 2899-2902. https://doi.org/10.3892/ol.2016.4307
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team