|
1
|
Cantley LC: The phosphoinositide 3-kinase
pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Vogelstein B and Kinzler KW: Cancer genes
and the pathways they control. Nat Med. 10:789–799. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Akinleye A, Avvaru P, Furqan M, Song Y and
Liu D: Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer
therapeutics. J Hematol Oncol. 6:882013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ocana A, Vera-Badillo F, Al-Mubarak M,
Templeton AJ, Corrales-Sanchez V, Diez-Gonzalez L, Cuenca-Lopez MD,
Seruga B, Pandiella A and Amir E: Activation of the PI3K/mTOR/AKT
pathway and survival in solid tumors: Systematic review and
meta-analysis. PLoS One. 9:e952192014. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ott PA and Adams S: Small-molecule protein
kinase inhibitors and their effects on the immune system:
Implications for cancer treatment. Immunotherapy. 3:213–227. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kummar S, Kinders R, Gutierrez ME,
Rubinstein L, Parchment RE, Phillips LR, Ji J, Monks A, Low JA,
Chen A, et al: Phase 0 clinical trial of the poly (ADP-ribose)
polymerase inhibitor ABT-888 in patients with advanced
malignancies. J Clin Oncol. 27:2705–2711. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Vara Fresno JA, Casado E, de Castro J,
Cejas P, Belda-Iniesta C and González-Barón M: PI3K/Akt signalling
pathway and cancer. Cancer Treat Rev. 30:193–204. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wilson JM, Kunnimalaiyaan S,
Kunnimalaiyaan M and Gamblin TC: Inhibition of the AKT pathway in
cholangiocarcinoma by MK2206 reduces cellular viability via
induction of apoptosis. Cancer Cell Int. 15:132015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Osaki M, Oshimura M and Ito H: PI3K-Akt
pathway: Its functions and alterations in human cancer. Apoptosis.
9:667–676. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Patel S: Exploring novel therapeutic
targets in GIST: Focus on the PI3K/Akt/mTOR pathway. Curr Oncol
Rep. 15:386–395. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu P, Cheng H, Roberts TM and Zhao JJ:
Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev
Drug Discov. 8:627–644. 2009. View
Article : Google Scholar : PubMed/NCBI
|
|
12
|
Samuels Y, Wang Z, Bardelli A, Silliman N,
Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, et al:
High frequency of mutations of the PIK3CA gene in human cancers.
Science. 304:5542004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Demetriades C, Doumpas N and Teleman AA:
Regulation of TORC1 in response to amino acid starvation via
lysosomal recruitment of TSC2. Cell. 156:786–799. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yewale C, Baradia D, Vhora I, Patil S and
Misra A: Epidermal growth factor receptor targeting in cancer: A
review of trends and strategies. Biomaterials. 34:8690–8707. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Schlegel J, Sambade MJ, Sather S, Moschos
SJ, Tan AC, Winges A, DeRyckere D, Carson CC, Trembath DG, Tentler
JJ, et al: MERTK receptor tyrosine kinase is a therapeutic target
in melanoma. J Clin Invest. 123:2257–2267. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Cummings CT, DeRyckere D, Earp HS and
Graham DK: Molecular pathways: MERTK signaling in cancer. Clin
Cancer Res. 19:5275–5280. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Karassek S, Berghaus C, Schwarten M,
Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S,
Herrmann C, et al: Ras homolog enriched in brain (Rheb) enhances
apoptotic signaling. J Biol Chem. 285:33979–33991. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Du W, Gerald D, Perruzzi CA,
Rodriguez-Waitkus P, Enayati L, Krishnan B, Edmonds J, Hochman ML,
Lev DC and Phung TL: Vascular tumors have increased p70 S6-kinase
activation and are inhibited by topical rapamycin. Lab Invest.
93:1115–1127. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Juskevicius D, Ruiz C, Dirnhofer S and
Tzankov A: Clinical, morphologic, phenotypic and genetic evidence
of cyclin D1-positive diffuse large B-cell lymphomas with cyclin D1
gene rearrangements. Am J Surg Pathol. 38:719–727. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Hejnold M, Dyduch G, Białas M, Demczuk S,
Ryś J, Chłosta P, Szopiński T and Okoń K: Selected
immunohistochemical features of conventional renal cell carcinomas
coexpressing P53 and MDM2. Pol J Pathol. 65:113–119. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang H, Chen P, Liu XX, Zhao W, Shi L, Gu
XW, Zhu CR, Zhu HH and Zong L: Prognostic impact of
gastrointestinal bleeding and expression of PTEN and Ki-67 on
primary gastrointestinal stromal tumors. World J Surg Oncol.
12:892014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Luo J, Manning BD and Cantley LC:
Targeting the PI3K-Akt pathway in human cancer: Rationale and
promise. Cancer Cell. 4:257–262. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Qiu W, Tong GX, Turk AT, Close LG, Caruana
SM and Su GH: Oncogenic PIK3CA mutation and dysregulation in human
salivary duct carcinoma. Biomed Res Int. 2014:8104872014.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Cho DC: Targeting the PI3K/Akt/mTOR
pathway in malignancy: Rationale and clinical outlook. BioDrugs.
28:373–381. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Li X and Jope RS: Is glycogen synthase
kinase-3 a central modulator in mood regulation?
Neuropsychopharmacology. 35:2143–2154. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Huang N, Zhu J, Liu D, Li YL, Chen BJ, He
YQ, Liu K, Mo XM and Li WM: Overexpression of Bcl-2-associated
death inhibits A549 cell growth in vitro and in vivo.
Cancer Biother Radiopharm. 27:164–168. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Cooray S: The pivotal role of phosphatidyl
inositol 3-kinase-Akt signal transduction in virus survival. J Gen
Virol. 85:1065–1076. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yang F, Deng R, Qian XJ, Chang SH, Wu XQ,
Qin J, Feng GK, Ding K and Zhu XF: Feedback loops blockade
potentiates apoptosis induction and antitumor activity of a novel
AKT inhibitor DC120 in human liver cancer. Cell Death Dis.
5:e11142014. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Taelman VF, Dobrowolski R, Plouhinec JL,
Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD and De Robertis
EM: Wnt signaling requires sequestration of gycogen synthase kinase
3 inside multivesicular endosomes. Cell. 143:1136–1148. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang J, Xin YF, Xu WJ, Liu ZM, Qiu XB, Qu
XK, Xu L, Li X and Yang YQ: Prevalence and spectrum of PITX2c
mutations associated with congenital heart disease. DNA Cell Biol.
32:708–716. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Símová S, Klíma M, Cermak L, Sourková V
and Andera L: Arf and Rho GAP adapter protein ARAP1 participates in
the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis.
13:423–436. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gan X, Wang J, Wang C, Sommer E, Kozasa T,
Srinivasula S, Alessi D, Offermanns S, Simon MI and Wu D: PRR5L
degradation promotes mTORC2-mediated PKC-delta phosphorylation and
cell migration downstream of G α 12. Nat Cell Biol. 14:686–696.
2012. View
Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kuroyanagi H: Fox-1 family of RNA-binding
proteins. Cell Mol Life Sci. 66:3895–3907. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Greenberg EF, Lavik AR and Distelhorst CW:
Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and
calcium signaling in normal and malignant lymphocytes: Potential
new target for cancer treatment. Biochim Biophys Acta.
1843:2205–2210. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Bose P, Rahmani M and Grant S: Coordinate
PI3K pathway and Bcl-2 family disruption in AML. Oncotarget.
3:1499–1500. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Szlama G, Trexler M and Patthy L: Latent
myostatin has significant activity and this activity is controlled
more efficiently by WFIKKN1 than by WFIKKN2. FEBS J. 280:3822–3839.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Kim MS, Yoo NJ and Lee SH: Expressional
and mutational analysis of CREBBP gene in gastric and colorectal
cancers with microsatellite instability. Pathol Oncol Res.
20:221–222. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Unno H, Futamura K, Morita H, Kojima R,
Arae K, Nakae S, Ida H, Saito H, Matsumoto K and Matsuda A: Silica
and double-stranded RNA synergistically induce bronchial epithelial
apoptosis and airway inflammation. Am J Respir Cell Mol Biol.
51:344–353. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Lackie JM, Coote JG and Lloyd CW: The
Dictionary of Cell & Molecular Biology (5th). Academic Press.
San Diego, CA: 2013. View Article : Google Scholar
|
|
40
|
Villa-Morales M, Cobos MA, González-Gugel
E, Álvarez-Iglesias V, Martínez B, Piris MA, Carracedo A, Benítez J
and Fernández-Piqueras J: FAS system deregulation in T-cell
lymphoblastic lymphoma. Cell Death Dis. 5:e11102014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Gupta R, Dong Y, Solomon PD, Wettersten
HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, et
al: Synergistic tumor suppression by combined inhibition of
telomerase and CDKN1A. Proc Natl Acad Sci USA. 111:E3062–E3071.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Thapa N and Anderson RA: PIP2 signaling,
an integrator of cell polarity and vesicle trafficking in
directionally migrating cells. Cell Adh Migr. 6:409–412. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Miyamoto M, Takano M, Iwaya K, Shinomiya
N, Kato M, Aoyama T, Sasaki N, Goto T, Suzuki A, Hitrata J and
Furuya K: X-chromosome-linked inhibitor of apoptosis as a key
factor for chemoresistance in clear cell carcinoma of the ovary. Br
J Cancer. 110:2881–2886. 2014. View Article : Google Scholar : PubMed/NCBI
|
