MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6

  • Authors:
    • Fang Huang
    • Yaofeng Jin
    • Yafeng Wei
  • View Affiliations

  • Published online on: March 8, 2016     https://doi.org/10.3892/ol.2016.4313
  • Pages: 2845-2850
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRs) are endogenous non-coding RNAs that serve key functions in a wide range of biological processes, including cell growth, development, apoptosis and carcinogenesis. However, the association between miR‑187 and B‑cell lymphoma 6 (BCL6) has yet to be fully investigated in lymphoma cell apoptosis. The present study hypothesized that a post‑translational mechanism may exist for BCL6 expression, which is regulated by miR‑187 in lymphoma cells. The present study demonstrated that the expression of miR‑187 in diffuse large B‑cell lymphoma (DLBCL) cells was significantly decreased, and its expression was negatively correlated with BCL6 expression. It was also observed that miR‑187 directly binds to the 3'‑untranslated region of BCL6 mRNA and subsequently suppresses the expression of BCL6. Additionally, the induced expression of miR‑187 significantly promoted DLBCL cell apoptosis in vitro. The drug sensitivity of human DLBCL SUDHL2 cells was increased following induction of miR-187 overexpression via an miR‑187 mimic. In conclusion, the results of the present study suggest that the modulation of miR-187 expression in DLBCL cells may improve the sensitivity of chemotherapy through BCL6 targeting.
View Figures
View References

Related Articles

Journal Cover

April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang F, Jin Y and Wei Y: MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6 . Oncol Lett 11: 2845-2850, 2016
APA
Huang, F., Jin, Y., & Wei, Y. (2016). MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6 . Oncology Letters, 11, 2845-2850. https://doi.org/10.3892/ol.2016.4313
MLA
Huang, F., Jin, Y., Wei, Y."MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6 ". Oncology Letters 11.4 (2016): 2845-2850.
Chicago
Huang, F., Jin, Y., Wei, Y."MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6 ". Oncology Letters 11, no. 4 (2016): 2845-2850. https://doi.org/10.3892/ol.2016.4313