Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis

  • Authors:
    • Gang Liu
    • Yi Li
    • Xiaogang Gao
  • View Affiliations

  • Published online on: March 9, 2016     https://doi.org/10.3892/ol.2016.4316
  • Pages: 2903-2908
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Abstract

Non-small cell lung cancer (NSCLC) accounts for 85% of all types of lung cancer and is the leading cause of world-wide cancer-associated mortalities. Radiation therapy has long been regarded as a fundamental therapeutic treatment strategy for NSCLC. However, alternative therapies for NSCLC remain insufficient, with the majority of cancers developing a high incidence of radioresistance. MicroRNAs (miRNAs/miRs) are endogenous oligonucleotide RNAs that serve an important role in carcinogenesis and tumor progression. In the present study, a novel function of miR‑133b that is associated with the radiosensitivity of lung cancer cells is reported. miR‑133 was downregulated in radioresistant lung cancer cells, which exhibited an elevated glycolysis rate when compared with radiosensitive cells. Additionally, it was observed that pyruvate kinase isoform M2 (PKM2) is a target of miR-133b, and that the expression of PKM2 is positively correlated with radioresistance. Finally, it was demonstrated that overexpression of miR‑133b resensitizes radioresistant lung cancer cells through the inhibition of PKM2‑mediated glycolysis. The current study may indicate a novel function of miR‑133b, potentially aiding the development of anticancer therapeutics.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu G, Li Y and Gao X: Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis. Oncol Lett 11: 2903-2908, 2016
APA
Liu, G., Li , Y., & Gao, X. (2016). Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis. Oncology Letters, 11, 2903-2908. https://doi.org/10.3892/ol.2016.4316
MLA
Liu, G., Li , Y., Gao, X."Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis". Oncology Letters 11.4 (2016): 2903-2908.
Chicago
Liu, G., Li , Y., Gao, X."Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis". Oncology Letters 11, no. 4 (2016): 2903-2908. https://doi.org/10.3892/ol.2016.4316