Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma

  • Authors:
    • Dahang Zhao
    • Xiangjie Liu
    • Yunge Zhang
    • Zhaoming Ding
    • Feng Dong
    • Hongwei Xu
    • Baoxin Wang
    • Wenbo Wang
  • View Affiliations

  • Published online on: March 9, 2016     https://doi.org/10.3892/ol.2016.4324
  • Pages: 2869-2874
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Abstract

Osteosarcoma is the most prevalent type of primary malignant bone tumor. Inhibitor of growth 4 (ING4) has been demonstrated to function as a tumor suppressor through multiple pathways, and is its expression is understood to be suppressed or reduced in various malignancies. The present study aimed to investigate the expression of ING4 and to determine its prognostic value in osteosarcoma tissue. Formalin‑fixed, paraffin‑embedded tissue microarrays were analyzed, and contained 41 osteosarcoma specimens and 11 normal bone tissue specimens with duplicate cores. ING4 expression was evaluated by immunohistochemical staining. The association between ING4 expression in the osteosarcoma and normal bone tissues was analyzed, in addition to the association between ING4 expression and Enneking classification of the osteosarcoma tissues. A significant statistical difference was observed in the ING4 immunohistochemical staining score between the osteosarcoma and normal bone tissues (P<0.001). Furthermore, a significant negative correlation was detected between the ING4 immunohistochemical staining scores and the Enneking classification results of the 41 osteosarcoma tissues (P=0.002). Low expression of ING4 was observed in the osteosarcoma specimens, and this reduced expression of ING4 was negatively correlated with Enneking classification. Thus, the results of the present study indicate that ING4 may serve as a promising prognostic marker in osteosarcoma.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao D, Liu X, Zhang Y, Ding Z, Dong F, Xu H, Wang B and Wang W: Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma. Oncol Lett 11: 2869-2874, 2016
APA
Zhao, D., Liu, X., Zhang, Y., Ding, Z., Dong, F., Xu, H. ... Wang, W. (2016). Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma. Oncology Letters, 11, 2869-2874. https://doi.org/10.3892/ol.2016.4324
MLA
Zhao, D., Liu, X., Zhang, Y., Ding, Z., Dong, F., Xu, H., Wang, B., Wang, W."Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma". Oncology Letters 11.4 (2016): 2869-2874.
Chicago
Zhao, D., Liu, X., Zhang, Y., Ding, Z., Dong, F., Xu, H., Wang, B., Wang, W."Reduced expression and prognostic implication of inhibitor of growth 4 in human osteosarcoma". Oncology Letters 11, no. 4 (2016): 2869-2874. https://doi.org/10.3892/ol.2016.4324