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Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review

  • Authors:
    • Shang‑Jun Jiang
    • Li‑Yin Ye
    • Fan‑Hua Meng
  • View Affiliations / Copyright

    Affiliations: Department of Urinary Surgery, The People's Hospital of Fuyang, Hangzhou, Zhejiang 311400, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2751-2756
    |
    Published online on: March 9, 2016
       https://doi.org/10.3892/ol.2016.4325
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Abstract

The aim of the present meta‑analysis was to compare the benefits of Bacillus Calmetter‑Guerin (BCG) and mitomycin C in the treatment of patients with superficial bladder cancer. The present meta‑analysis analyzed the benefits of BCG and mitomycin C in the treatment of patients with superficial bladder cancer by comparing progression‑free survival (PFS) rates in patients treated with either of the drugs following transurethral resection. The Medline, Cochrane and EMBASE databases were searched between January 1966 and August 31, 2014 for studies that investigated the efficacy of the intravesical instillation of chemotherapy in patients with non‑muscle invasive bladder cancer who had been treated with transurethral resection. Search terms included: ‘Urinary bladder neoplasms’, ‘superficial bladder cancer’ and ‘non‑muscle invasive bladder cancer’; ‘bacillus Calmette‑Guerin’ or ‘BCG’; ‘mitomycin C’; and ‘intravesical administration’. Sensitivity and data quality analyses were performed. A total of 6 randomized controlled studies were included with 1,289 patients. Complete 5‑year PFS data for patients who received intravesical resection and were treated with mitomycin C or BCG was provided for 3 of the 6 studies, which were therefore included in the meta‑analysis. The overall analysis revealed a significant benefit of BCG compared with mitomycin C in terms of 5‑year PFS rate (odds ratio, 0.53; 95% confidence interval, 0.38‑0.75; P<0.001), indicating that BCG was superior to mitomycin C therapy in patients with non‑muscle invasive bladder cancer following transurethral resection.
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1 

Lamm D, Herr H, Jakse G, Kuroda M, Mostofi FK, Okajima E, Sakamoto A, Sesterhenn I and da Silva FC: Updated concepts and treatment of carcinoma in situ. Urol Oncol. 4:130–138. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Witjes JA, Palou J, Soloway M, Lamm D, Kamat AM, Brausi M, Persad R, Buckley R, Colombel M and Böhle A: Current clinical practice gaps in the treatment of intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC) with emphasis on the use of bacillus Calmette-Guérin (BCG): Results of an international individual patient data survey (IPDS). BJU Int. 112:742–750. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Shelley MD, Jones G, Cleves A, Wilt TJ, Mason MD and Kynaston HG: Intravesical gemcitabine therapy for non-muscle invasive bladder cancer (NMIBC): A systematic review. BJU Int. 109:496–505. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A, Palou-Redorta J and Rouprêt M: European Association of Urology (EAU): EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Eur Urol. 59:997–1008. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Pawinski A, Sylvester R, Kurth KH, Bouffioux C, van der Meijden A, Parmar MK and Bijnens L: A combined analysis of European organization for research and treatment of cancer and medical research Council randomized clinical trials for the prophylactic treatment of stage TaT1 bladder cancer. European organization for research and treatment of cancer genitourinary tract cancer cooperative group and the medical research council working party on superficial bladder cancer. J Urol. 156:1934–1940; discussion 1940–1941. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Shelley MD, Kynaston H, Court J, Wilt TJ, Coles B, Burgon K and Mason MD: A systematic review of intravesical bacillus Calmette-Guérin plus transurethral resection vs. transurethral resection alone in Ta and T1 bladder cancer. BJU Int. 88:209–216. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Han RF and Pan JG: Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with superficial bladder cancer? A meta-analysis of randomized trials. Urology. 67:1216–1223. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Böhle A, Jocham D and Bock PR: Intravesical bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: A formal meta-analysis of comparative studies on recurrence and toxicity. J Urol. 169:90–95. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Sylvester RJ, van der Meijden AP and Lamm DL: Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: A meta-analysis of the published results of randomized clinical trials. J Urol. 168:1964–1970. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Böhle A and Bock PR: Intravesical bacille Calmette-Guérin versus mitomycin C in superficial bladder cancer: Formal meta-analysis of comparative studies on tumor progression. Urology. 63:682–686; discussion 686–687. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Malmström PU: Management of superficial bladder cancer: What is new? Curr Opin Urol. 10:447–451. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Shelley MD, Wilt TJ, Court J, Coles B, Kynaston H and Mason MD: Intravesical bacillus Calmette-Guérin is superior to mitomycin C in reducing tumour recurrence in high-risk superficial bladder cancer: A meta-analysis of randomized trials. BJU Int. 93:485–490. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Shelley MD, Mason MD and Kynaston H: Intravesical therapy for superficial bladder cancer: A systematic review of randomised trials and meta-analyses. Cancer Treat Rev. 36:195–205. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 151:W65–W94. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Higgins JPT: Cochrane Collaboration Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. 2011.simplewww.cochrane-handbook.orgAccessed. November 12–2014

17 

Sutton AJ, Duval SJ, Tweedie RL, Abrams KR and Jones DR: Empirical assessment of effect of publication bias on meta-analyses. BMJ. 320:1574–1577. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Friedrich MG, Pichlmeier U, Schwaibold H, Conrad S and Huland H: Long-term intravesical adjuvant chemotherapy further reduces recurrence rate compared with short-term intravesical chemotherapy and short-term therapy with Bacillus Calmette-Guérin (BCG) in patients with non-muscle-invasive bladder carcinoma. Eur Urol. 52:1123–1129. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Ojea A, Nogueira JL, Solsona E, Flores N, Gómez JM, Molina JR, Chantada V, Camacho JE, Piñeiro LM, Rodríguez RH, et al: A multicentre, randomised prospective trial comparing three intravesical adjuvant therapies for intermediate-risk superficial bladder cancer: Low-dose bacillus Calmette-Guerin (27 mg) versus very low-dose bacillus Calmette-Guerin (13.5 mg) versus mitomycin C. Eur Urol. 52:1398–1406. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Di Stasi SM, Giannantoni A, Stephen RL, Capelli G, Navarra P, Massoud R and Vespasiani G: Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: A prospective randomized study. J Urol. 170:777–782. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Malmström PU, Wijkström H, Lundholm C, Wester K, Busch C and Norlén BJ: 5-year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma. Swedish-Norwegian bladder cancer study group. J Urol. 161:1124–1127. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Krege S, Giani G, Meyer R, Otto T and Rübben H: A randomized multicenter trial of adjuvant therapy in superficial bladder cancer: Transurethral resection only versus transurethral resection plus mitomycin C versus transurethral resection plus bacillus Calmette-Guerin. Participating Clinics. J Urol. 156:962–966. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Rintala E, Jauhiainen K, Alfthan O, Hansson E, Juusela H, Kanerva K, Korhonen H, Permi J, Sotarauta M, Vaalasti T, et al: Intravesical chemotherapy (mitomycin C) versus immunotherapy (bacillus Calmette-Guérin) in superficial bladder cancer. Eur Urol. 20:19–25. 1991.PubMed/NCBI

24 

Zhu S, Tang Y, Li K, Shang Z, Jiang N, Nian X, Sun L and Niu Y: Optimal schedule of bacillus calmette-guerin for non-muscle-invasive bladder cancer: A meta-analysis of comparative studies. BMC Cancer. 13:3322013. View Article : Google Scholar : PubMed/NCBI

25 

Malmström PU, Sylvester RJ, Crawford DE, Friedrich M, Krege S, Rintala E, Solsona E, Di Stasi SM and Witjes JA: An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guerin for non-muscle-invasive bladder cancer. Eur Urol. 56:247–256. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Yoneyama T, Ohyama C, Imai A, Ishimura H, Hagisawa S, Iwabuchi I, Mori K, Kamimura N, Koie T, Yamato T and Suzuki T: Low-dose instillation therapy with bacille Calmette-Guérin Tokyo 172 strain after transurethral resection: Historical cohort study. Urology. 71:1161–1165. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Kumar A, Dubey D, Bansal P, Mandhani A and Naik S: Urinary interleukin-8 predicts the response of standard and low dose intravesical bacillus Calmette-Guerin (modified Danish 1331 strain) for superficial bladder cancer. J Urol. 168:2232–2235. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Irie A, Uchida T, Yamashita H, Matsumoto K, Satoh T, Koh H, Shimura S, Iwamura M and Baba S: Sufficient prophylactic efficacy with minor adverse effects by intravesical instillation of low-dose bacillus Calmette-Guérin for superficial bladder cancer recurrence. Int J Urol. 10:183–189. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang SJ, Ye LY and Meng FH: Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review. Oncol Lett 11: 2751-2756, 2016.
APA
Jiang, S., Ye, L., & Meng, F. (2016). Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review. Oncology Letters, 11, 2751-2756. https://doi.org/10.3892/ol.2016.4325
MLA
Jiang, S., Ye, L., Meng, F."Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review". Oncology Letters 11.4 (2016): 2751-2756.
Chicago
Jiang, S., Ye, L., Meng, F."Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review". Oncology Letters 11, no. 4 (2016): 2751-2756. https://doi.org/10.3892/ol.2016.4325
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang SJ, Ye LY and Meng FH: Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review. Oncol Lett 11: 2751-2756, 2016.
APA
Jiang, S., Ye, L., & Meng, F. (2016). Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review. Oncology Letters, 11, 2751-2756. https://doi.org/10.3892/ol.2016.4325
MLA
Jiang, S., Ye, L., Meng, F."Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review". Oncology Letters 11.4 (2016): 2751-2756.
Chicago
Jiang, S., Ye, L., Meng, F."Comparison of intravesical bacillus Calmette‑Guerin and mitomycin C administration for non‑muscle invasive bladder cancer: A meta‑analysis and systematic review". Oncology Letters 11, no. 4 (2016): 2751-2756. https://doi.org/10.3892/ol.2016.4325
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