Clinical pathology of metastatic gastric carcinoma to the breast: A report of two cases and a review of literature

Tian,Qiuhong; Zeng,Jinsheng; Tao,Xueqin; Zhang,Zhanmin; Zhou,Xiaodong; Wang,Yiting

doi:10.3892/ol.2016.4350

Clinical pathology of metastatic gastric carcinoma to the breast: A report of two cases and a review of literature

Authors:
- Qiuhong Tian
- Jinsheng Zeng
- Xueqin Tao
- Zhanmin Zhang
- Xiaodong Zhou
- Yiting Wang
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Affiliations: Department of Oncology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Published online on: March 17, 2016 https://doi.org/10.3892/ol.2016.4350
Pages: 3081-3084

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Abstract

The breast is an unusual site for metastasis from a gastric carcinoma. The present study reports two cases of metastatic gastric carcinoma to the breast. The first patient, a 37year-old woman, initially presented with gastric adenocarcinoma, prior to developing metastatic cancer to the breast 4 years later. The second female patient presented with a breast mass, and a modified radical mastectomy was performed; however, the subsequent pathological examination revealed the mass to be a metastatic signet ring cell carcinoma. An abdominal computed tomography scan revealed a diffuse gastric wall thickening that was consistent with gastric cancer. The findings suggest that immunohistochemistry is a useful tool to differentiate between primary breast tumors and gastrointestinal carcinomas that have metastasized to the breast. Additional studies are required in order to define the optimal treatment.

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