Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells

Zhai,Xiao‑Xiang; Ding,Ji‑Cun; Tang,Zhi‑Ming; Li,Jing‑Guo; Li,Yong‑Cong; Yan,Yue‑Hua; Sun,Jing‑Chang; Zhang,Cui‑Xia

doi:10.3892/ol.2016.4351

May-2016 Volume 11 Issue 5

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May-2016 Volume 11 Issue 5

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Article Open Access

Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells

Authors:
- Xiao‑Xiang Zhai
- Ji‑Cun Ding
- Zhi‑Ming Tang
- Jing‑Guo Li
- Yong‑Cong Li
- Yue‑Hua Yan
- Jing‑Chang Sun
- Cui‑Xia Zhang
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Affiliations: Department of Dermatology, Traditional Chinese Medicine Hospital of Xuzhou City, Xuzhou, Jiangsu 221003, P.R. China, Department of Plastic Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China, Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Cell Biology Laboratory, School of Basic Medicine, Shandong Medical University, Jinan, Shandong 250355, P.R. China

Copyright: © Zhai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3015-3018
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Published online on: March 18, 2016

https://doi.org/10.3892/ol.2016.4351
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Abstract

The aim of the present study was to investigate the effect of resveratrol on cell apoptosis, ability of telomerase and the human telomerase reverse transcriptase (hTERT) protein expression in human A431 epidermoid carcinoma cells. A431 cells were treated with different concentrations of resveratrol, and the cell appearance was then observed under a microscope. In addition, the cell proliferation was examined using an MTT assay, and the ability of telomerase was detected using telomeric repeat amplification protocol‑polymerase chain reaction‑ELISA. Resveratrol significantly inhibited the ability of telomerase and decreased the expression of hTERT protein in a concentration-dependent manner. In conclusion, resveratrol is capable of downregulating the expression of hTERT protein and inhibits the ability of telomerase of A431, which is an important mechanism of action of resveratrol with regard to inhibition of A431 cell proliferation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells

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