Open Access

Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature

  • Authors:
    • Na Gao
    • Nong-Jian Guo
    • Wen‑Zheng Yu
    • Xue‑Xia Wang
    • Jian‑Rong Sun
    • Ning Yu
    • Ren‑Tong Liu
    • Xiao‑Dan Liu
    • Zeng‑Yan Liu
    • Rui Feng
  • View Affiliations

  • Published online on: March 18, 2016     https://doi.org/10.3892/ol.2016.4353
  • Pages: 2977-2980
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gastrointestinal stromal tumors (GISTs) originate from the mesenchymal tissue of the gastrointestinal tract. The pathogenesis of GIST is associated with the mutational activation of the receptor tyrosine kinase cluster of differentiation (CD)117 or platelet‑derived growth factor receptor‑α. Overall, ~60% of GISTs occur in the stomach. Clinically, GISTs may coexist with various types of cancer, including liver cancer, pancreatic tumors and lymphoma, either synchronously or metachronously. The present study reports the case of a patient with the synchronous occurrence of a CD117-positive GIST and acute myeloid leukemia. A 69‑year‑old man was hospitalized for heart palpitations and dizziness, and was diagnosed with acute myeloid leukemia (AML) by bone marrow aspiration and flow cytometry analysis. An abdominal computed tomograpy and gastroscopy revealed the presence of GIST. The patient received chemotherapy in combination with imatinib (400 mg/day), and the mass was removed 2 months later. To the best of our knowledge, the present study is the first reported case of the synchronous development of a CD117-positive GIST and AML. Additional studies are required in order to understand the association between GIST and hematological malignancies.
View Figures
View References

Related Articles

Journal Cover

May-2016
Volume 11 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao N, Guo N, Yu WZ, Wang XX, Sun JR, Yu N, Liu RT, Liu XD, Liu ZY, Feng R, Feng R, et al: Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncol Lett 11: 2977-2980, 2016
APA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N. ... Feng, R. (2016). Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncology Letters, 11, 2977-2980. https://doi.org/10.3892/ol.2016.4353
MLA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11.5 (2016): 2977-2980.
Chicago
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11, no. 5 (2016): 2977-2980. https://doi.org/10.3892/ol.2016.4353