Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2016 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2016 Volume 11 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature

  • Authors:
    • Na Gao
    • Nong-Jian Guo
    • Wen‑Zheng Yu
    • Xue‑Xia Wang
    • Jian‑Rong Sun
    • Ning Yu
    • Ren‑Tong Liu
    • Xiao‑Dan Liu
    • Zeng‑Yan Liu
    • Rui Feng
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China, Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Department of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2977-2980
    |
    Published online on: March 18, 2016
       https://doi.org/10.3892/ol.2016.4353
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastrointestinal stromal tumors (GISTs) originate from the mesenchymal tissue of the gastrointestinal tract. The pathogenesis of GIST is associated with the mutational activation of the receptor tyrosine kinase cluster of differentiation (CD)117 or platelet‑derived growth factor receptor‑α. Overall, ~60% of GISTs occur in the stomach. Clinically, GISTs may coexist with various types of cancer, including liver cancer, pancreatic tumors and lymphoma, either synchronously or metachronously. The present study reports the case of a patient with the synchronous occurrence of a CD117-positive GIST and acute myeloid leukemia. A 69‑year‑old man was hospitalized for heart palpitations and dizziness, and was diagnosed with acute myeloid leukemia (AML) by bone marrow aspiration and flow cytometry analysis. An abdominal computed tomograpy and gastroscopy revealed the presence of GIST. The patient received chemotherapy in combination with imatinib (400 mg/day), and the mass was removed 2 months later. To the best of our knowledge, the present study is the first reported case of the synchronous development of a CD117-positive GIST and AML. Additional studies are required in order to understand the association between GIST and hematological malignancies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Iorio N, Sawaya RA and Friedenberg FK: Review article: The biology, diagnosis and management of gastrointestinal stromal tumours. Aliment Pharmacol Ther. 39:1376–1386. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Chen HL, Xia JG and Ding HB: Imaging features and differential diagnosis of gastrointestinal stromal tumor. Yixue Lilun Yu Shijian. 17:2337–2339. 2013.(In Chinese).

3 

Bello DM, Dematteo RP and Ariyan CE: The GIST of targeted therapy for malignant melanoma. Ann Surg Oncol. 21:2059–2067. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Voltaggio L, Murray R, Lasota J and Miettinen M: Gastric schwannoma: A clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol. 43:650–659. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Corless CL, Barnett CM and Heinrich MC: Gastrointestinal stromal tumours: Origin and molecular oncology. Nat Rev Cancer. 11:865–878. 2011.PubMed/NCBI

6 

Miettinen M and Lasota J: Histopathology of gastrointestinal stromal tumor. J Surg Oncol. 104:865–873. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Fan CHL and Li ZHQ: Clinical pathological and immunohistochemical characteristics of 78 cases of gastrointestinal stromal tumor. Shi Yong Zhong Liu Za Zhi. 25:581–583. 2010.(In Chinese).

8 

Liu SW, Chen GH and Hsieh PP: Collision tumor of the stomach: A case report of mixed gastrointestinal stromal tumor and adeno-carcinoma. J Clin Gastroenterol. 35:332–334. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Herbers AH and Keuning JJ: Staging for CLL-type non-Hodgkin lymphoma reveals a gastrointestinal stromal tumour. Neth J Med. 63:74–75. 2005.PubMed/NCBI

10 

Agaimy A, Wünsch PH, Sobin LH, Lasota J and Miettinen M: Occurrence of other malignancies in patients with gastro-intestinal stromal tumors. Semin Diagn Pathol. 23:120–129. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Joo YB, Choi SH, Kim SK, Shim B, Kim MS and Kim YJ: Synchronous development of KIT positive acute myeloid leukemia in a patient with gastrointestinal stromal tumor. Korean J Hematol. 45:66–69. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Hematology Society, Chinese Medical Association: Adult acute myeloid leukemia (non acute early myeloid leukemia) Chinese guidelines for diagnosis and treatment. (2011 Edition). Chinese Journal of Hematology. 32:1–4. 2011.(In Chinese). PubMed/NCBI

13 

Sonmez M, Arslan M, Cobanoglu U, Kavgaci H, Ozbas HM, Aydin F, Ovali E and Omay SB: Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. Tumori. 95:240–242. 2009.PubMed/NCBI

14 

Kim MN, Kang SJ, Kim SG, Im JP, Kim JS, Jung HC and Song IS: Prediction of risk of malignancy of gastrointestinal stromal tumors by endoscopic ultrasonography. Gut Liver. 7:642–647. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Lewin KJ, Riddell RH and Weinstein WM: Gastrointestinal Pathology and Its Clinical Implications. Igaku-Shoin. New York, NY: 284–341. 1992.

16 

Corless CL, Fletcher JA and Heinrich MC: Biology of gastrointestinal stromal tumors. J Clin Oncol. 22:3813–3825. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Joensuu H: Gastrointestinal stromal tumor (GIST). Ann Oncol. 7(Suppl 10×): 280–x286. 2006. View Article : Google Scholar

18 

Yoshioka K, Yamaguchi M, Kasamatsu Y, Ashida K, Yokoh S, Tatebe A, Yoshida T and Kondo M: Acute promyoelocytic leukemia following leiomyosarcoma of the jejunum. Arch Intern Med. 157:1392–1393. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Antonescu CR: The GIST paradigm: Lessons for other kinase-driven cancers. J Pathol. 223:251–261. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Yamanoi K, Higuchi K, Kishimoto H, Nishida Y, Nakamura M, Sudoh M and Hirota S: Multiple gastrointestinal stromal tumors with novel germline c-kit gene mutation, K642T, at exon 13. Hum Pathol. 45:884–888. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Conca E, Miranda C, Dal Col V, Fumagalli E, Pelosi G, Mazzoni M, Fermeglia M, Laurini E, Pierotti MA, Pilotti S, et al: Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib. Mol Oncol. 7:756–762. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Shen HQ, Tang YM, Yang SL, Qian BQ, Song H, Shi SW and Xu WQ: Analysis of CD117 expression on leukemia cells. Zhonghua Xue Ye Xue Za Zhi. 24:228–230. 2003.(In Chinese). PubMed/NCBI

23 

Tsao AS, Kantarjian H, Thomas D, Giles F, Cortes J, Garcia-Manero G, Huh Y, Yang Y, Shen Y, Albitar M, et al: C-kit receptor expression in acute leukemias-association with patient and disease characteristics and with outcome. Leuk Res. 28:373–378. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Wang WL, Conley A, Reynoso D, Nolden L, Lazar AJ, George S and Trent JC: Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor. Cancer Chemother Pharmacol. 67(Suppl 1): S15–S24. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Chen SQ and Xiong AQ: The progress and implication of stem cell factor. Basic Med Sci Clin. 22:385–390. 2002.

26 

Miettinen M, Kraszewska E, Sobin LH and Lasota J: A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer. 112:645–649. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao N, Guo N, Yu WZ, Wang XX, Sun JR, Yu N, Liu RT, Liu XD, Liu ZY, Feng R, Feng R, et al: Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncol Lett 11: 2977-2980, 2016.
APA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N. ... Feng, R. (2016). Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncology Letters, 11, 2977-2980. https://doi.org/10.3892/ol.2016.4353
MLA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11.5 (2016): 2977-2980.
Chicago
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11, no. 5 (2016): 2977-2980. https://doi.org/10.3892/ol.2016.4353
Copy and paste a formatted citation
x
Spandidos Publications style
Gao N, Guo N, Yu WZ, Wang XX, Sun JR, Yu N, Liu RT, Liu XD, Liu ZY, Feng R, Feng R, et al: Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncol Lett 11: 2977-2980, 2016.
APA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N. ... Feng, R. (2016). Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncology Letters, 11, 2977-2980. https://doi.org/10.3892/ol.2016.4353
MLA
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11.5 (2016): 2977-2980.
Chicago
Gao, N., Guo, N., Yu, W., Wang, X., Sun, J., Yu, N., Liu, R., Liu, X., Liu, Z., Feng, R."Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature". Oncology Letters 11, no. 5 (2016): 2977-2980. https://doi.org/10.3892/ol.2016.4353
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team