Primary diffuse large B-cell lymphoma of the central nervous system: A case report and literature review

Chen,Dawei; Gu,Weihong; Li,Wenzhong; Liu,Xiaoliang; Yang,Xiaoyu

doi:10.3892/ol.2016.4365

Primary diffuse large B-cell lymphoma of the central nervous system: A case report and literature review

Authors:
- Dawei Chen
- Weihong Gu
- Wenzhong Li
- Xiaoliang Liu
- Xiaoyu Yang
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Affiliations: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
Published online on: March 22, 2016 https://doi.org/10.3892/ol.2016.4365
Pages: 3085-3090

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Abstract

The present study reports the clinical diagnosis and management of a patient with primary diffuse large B-cell lymphoma (Bcl) of the central nervous system (CNS). Making an early diagnosis of primary diffuse large Bcl is challenging due to the variable and complicated clinical manifestations of the disease. The relevant literature was reviewed, and high‑dose methotrexate, whole brain radiotherapy and highly active antiretroviral therapy was recommended for the patient. The present study elucidates the role of positron emission tomography‑computed tomography scans for the diagnosis and management of primary diffuse large Bcl of the CNS, and demonstrates the importance of resection surgery in the management of the disease. Specifically, the present study proposes that resection surgery may be applied in the early stages of disease for patients with a single occupied lesion and increased intracranial pressure.

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