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Article

Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer

  • Authors:
    • Rei Suzuki
    • Tadayuki Takagi
    • Takuto Hikichi
    • Naoki Konno
    • Mitsuru Sugimoto
    • Ko Watanabe
    • Jun Nakamura
    • Yuichi Waragai
    • Hitomi Kikuchi
    • Mika Takasumi
    • Hiroshi Watanabe
    • Hiromasa Ohira
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Endoscopy, School of Medicine, Fukushima Medical University, Fukushima 960‑1295, Japan
  • Pages: 3441-3445
    |
    Published online on: March 29, 2016
       https://doi.org/10.3892/ol.2016.4381
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Abstract

As gemcitabine is a key anti-tumor agent for unresectable pancreatic ductal adenocarcinoma (PDAC), it is important to predict the outcomes of gemcitabine chemotherapy. The present study aimed to confirm whether the derived neutrophil‑to‑lymphocyte ratio (dNLR) is able to predict chemotherapy outcomes. To elucidate the role of dNLR in patients that underwent chemotherapy, the current study evaluated clinicopathological variables in 31 patients with unresectable PDAC treated with gemcitabine. The correlation between clinicopathological variables, and progression‑free survival (PFS) and overall survival (OS) time were investigated. Univariate analysis revealed that there were no significant differences in PFS and OS as a function of age (<65 vs. ≥65 years), gender, tumor location (pancreas head vs. body/tail), tumor diameter (<23 vs. ≥23 mm) or serum carbohydrate antigen 19‑9 concentration level (<3,800 vs. ≥3,800 U/ml). However, disease stage (locally advanced vs. metastatic) and the dNLR (<2.5 vs. ≥2.5) significantly affected PFS and OS. Multivariate analysis subsequently revealed that a dNLR of ≥2.5 was an independent prognostic factor for poor PFS (P=0.003) and OS (P=0.026). In conclusion, data from the present study suggests that the pre‑treatment dNLR is an independent prognostic factor to predict PFS and OS in patients with unresectable PDAC treated with gemcitabine. This indicates that dNLR has a potential role in stratifying patients that may benefit from gemcitabine therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki R, Takagi T, Hikichi T, Konno N, Sugimoto M, Watanabe K, Nakamura J, Waragai Y, Kikuchi H, Takasumi M, Takasumi M, et al: Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer. Oncol Lett 11: 3441-3445, 2016.
APA
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K. ... Ohira, H. (2016). Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer. Oncology Letters, 11, 3441-3445. https://doi.org/10.3892/ol.2016.4381
MLA
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K., Nakamura, J., Waragai, Y., Kikuchi, H., Takasumi, M., Watanabe, H., Ohira, H."Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer". Oncology Letters 11.5 (2016): 3441-3445.
Chicago
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K., Nakamura, J., Waragai, Y., Kikuchi, H., Takasumi, M., Watanabe, H., Ohira, H."Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer". Oncology Letters 11, no. 5 (2016): 3441-3445. https://doi.org/10.3892/ol.2016.4381
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki R, Takagi T, Hikichi T, Konno N, Sugimoto M, Watanabe K, Nakamura J, Waragai Y, Kikuchi H, Takasumi M, Takasumi M, et al: Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer. Oncol Lett 11: 3441-3445, 2016.
APA
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K. ... Ohira, H. (2016). Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer. Oncology Letters, 11, 3441-3445. https://doi.org/10.3892/ol.2016.4381
MLA
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K., Nakamura, J., Waragai, Y., Kikuchi, H., Takasumi, M., Watanabe, H., Ohira, H."Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer". Oncology Letters 11.5 (2016): 3441-3445.
Chicago
Suzuki, R., Takagi, T., Hikichi, T., Konno, N., Sugimoto, M., Watanabe, K., Nakamura, J., Waragai, Y., Kikuchi, H., Takasumi, M., Watanabe, H., Ohira, H."Derived neutrophil/lymphocyte ratio predicts gemcitabine therapy outcome in unresectable pancreatic cancer". Oncology Letters 11, no. 5 (2016): 3441-3445. https://doi.org/10.3892/ol.2016.4381
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