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Article

The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma

  • Authors:
    • Yaohong Zhang
    • Zhaoyun Luo
    • Liye Yang
    • Senming Chen
    • Chuzhi Chen
    • Zhixiong Lin
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Chaozhou People's Hospital, Chaozhou, Guangdong 521000, P.R. China, Medical Laboratory Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, Guangdong 521000, P.R. China, Department of Radiation Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515031, P.R. China
  • Pages: 3508-3514
    |
    Published online on: March 29, 2016
       https://doi.org/10.3892/ol.2016.4384
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Abstract

Early stage diagnosis and therapeutic outcomes of esophageal squamous cell carcinoma remain poor. In order to evaluate the association between 4 single nucleotide polymorphisms (SNPs) of X‑ray repair cross complementing protein 1 (XRCC1) and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma (ESCC), the present study identified 4 SNPs of XRCC1 and evaluated the distribution of these genotypes among patients with ESCC. Venous blood samples from 175 patients with ESCC were collected and DNA was extracted. The 4 SNPs of the XRCC1 gene fragment were amplified using three primer pairs, which were sequenced. The mismatches were analyzed and identified using Basic Local Alignment Search Tool software. The sensitivity to radiotherapy was graded as effective and non‑effective, according to the treatment results of the patients. The present study successfully amplified and sequenced 4 SNPs of XRCC1 in 112 out of the 175 patients with ESCC. The effective response rate of radiotherapy was 84.8% among the 112 patients. The effective response rate of patients with no mutation in the SNPs was 74.3%, and the rate increased to 89.6% in patients that had ≥1 mutation out of the 4 SNPs (χ2=4.389; P=0.036). For G28152A and G28152A mutations the effective response rate of patients was 91.2% (χ2=4.014; P=0.045) and 91.5% (χ2=4.451; P=0.035), respectively, which was significantly different compared to patients with no mutation (P=0.045 and P=0.035, respectively). The present results suggest that the 4 SNPs of XRCC1 are associated with the effective response rate of radiotherapy in patients with ESCC. The mutation of SNP G28152A was particularly important and may be a potential genomic predictor for radiotherapy sensitivity in patients with ESCC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Hongo M, Nagasaki Y and Shoji T: Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol. 24:729–735. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J and Simes J: Australasian Gastro-Intestinal Trials Group: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol. 8:226–234. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, et al: MAGIC Trial Participants: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 355:11–20. 2006. View Article : Google Scholar : PubMed/NCBI

5 

van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, et al: CROSS Group: Preoperative chemo-radiotherapy for esophageal or junctional cancer. N Engl J Med. 366:2074–2084. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y and Muto M: Recent advances from basic and clinical studies of esophageal squamous cell carcinoma. Gastroenterology. 149:1700–1715. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Merkow RP, Bilimoria KY, McCarter MD, Chow WB, Ko CY and Bentrem DJ: Use of multimodality neoadjuvant therapy for esophageal cancer in the United States: Assessment of 987 hospitals. Ann Surg Oncol. 19:357–364. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Yu X, Xiao H, Zhao B, Zhang X and Wang G: DNA repair gene ERCC1 C118T polymorphism predicts sensitivity of recurrent esophageal cancerto radiochemotherapy in a Chinese population. Thorac Cancer. 6:714–718. 2015. View Article : Google Scholar

9 

Zhang Z, Zhang Q, Wu M, Li N and Heng Z: Effects of 60 Co γ rays on radiosensitivity of down-regulated cell strain hOGG1 expressed genes. Lin Chuang Fang She Yi Xue Shou Ce. 6:238–241. 2006.(In Chinese).

10 

Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA and Wilson SH: XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks. Cell Res. 18:48–63. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Zhang L, Yao R, Fang S, Wang X and Li X: Polymorphisms of ERCC1 and XRCC1 predict the overall survival of advanced gastric cancerpatients receiving oxaliplatin-based chemotherapy. Int J Clin Exp Med. 8:18375–18382. 2015.PubMed/NCBI

12 

Li Q, Wu SG, Gao JM, Xu JJ, Hu LY and Xu T: Impact of esophageal cancer staging on overall survival and disease-free survival based on the 2010 AJCC classification by lymph nodes. J Radiat Res. 54:307–314. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sachsenheimer W, Piotrowski W and Bimmler T: Quality of life in patients with intracranial tumors on the basis of Karnofsky's performance status. J Neurooncol. 13:177–181. 1992. View Article : Google Scholar : PubMed/NCBI

14 

Kurokawa Y, Shibata T, Ando N, Seki S, Mukaida H and Fukuda H: Which is the optimal response criteria for evaluating preoperative treatment in esophagealcancer: RECIST or histology? Ann Surg Oncol. 20:3009–3014. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Liu S, Zou S, Zhao J, Zhou B, Wan Z, Jia H, Yuan K and He J: Association between polymorphism of XRCC1 gene and susceptibility to esophageal carcinoma. Shi Yong Zhong Liu Za Zhi. 28:253–260. 2013.(In Chinese).

16 

Ayiheng Q and Bogela A: Study on laryngeal cancer related on polymorphism of the Arg399Gln of XRCC1 DNA repair gene in different nationalities in Xinjiang. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 27:948–951, 954. 2013.(In Chinese). PubMed/NCBI

17 

Kiyohara C, Takayama K and Nakanishi Y: Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: A meta-analysis. Lung Cancer. 54:267–283. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Zhou Y and Che G: Analysis of the relationship between DNA repair gene polymorphisms and lung cancer susceptibility. J Environ Occup Med. 40:551–554. 2013.

19 

Hoeijmakers JH: DNA damage, aging, and cancer. N Engl J Med. 361:1475–1485. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ladiges WC: Mouse models of XRCC1 DNA repair polymorphisms and cancer. Oncogene. 25:1612–1619. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Almeida KH and Sobol RW: A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst). 6:695–711. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Zhou Q, Zou BW, Xu Y, Xue JX, Meng MB, Liu FJ, Deng L, Ma DY, Ao R and Lu Y: DNA repair gene polymorphisms and clinical outcome of patients with primary small cell carcinoma of the esophagus. Tumour Biol. 36:1539–1548. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, Zhu Y, Miao X, Tan W and Wei Q: Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res. 64:4378–4384. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Sreeja L, Syamala VS, Syamala V, Hariharan S, Raveendran PB, Vijayalekshmi RV, Madhavan J and Ankathil R: Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. J Cancer Res Clin Oncol. 134:645–652. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Yang XR, Diehl S, Pfeiffer R, Chen CJ, Hsu WL, Dosemeci M, Cheng YJ, Sun B, Goldstein AM and Hildesheim A: Chinese and American Genetic Epidemiology of NPC Study Team: Evaluation of risk factors for nasopharyngeal carcinoma in high-risk nasopharyngeal carcinoma families in Taiwan. Cancer Epidemiol Biomarkers Prev. 14:900–905. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Huang J, Zhang J, Zhao Y, Liao B, Liu J, Li L, Liao M and Wang L: The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: A meta-analysis. Mol Biol Rep. 38:4565–4573. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Wu KS, Hou X, Shao G and Li Y: Meta-analysis of X-ray repair cross complementing gene 1 polymorphisms and esophageal cancer risk. J Shantou Univ Med Col. 20:206–209, 212. 2007.

28 

Liu S, Mu K, Zhang Z, Zeng M and Ge F: A correlation study of the expression of XRCC1 and ERCC1 to the effect of radiotherapy and prognosis in esophageal squamous cell carcinoma. J Xinjiang Med Univ. 33:477–481. 2010.

29 

Warnecke-Eberz U, Vallböhmer D, Alakus H, Kütting F, Lurje G, Bollschweiler E, Wienand-Dorweiler A, Drebber U, Hölscher AH and Metzger R: ERCC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer. J Gastrointest Surg. 13:1411–1421. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Cornetta T, Festa F, Testa A and Cozzi R: DNA damage repair and genetic polymorphisms: Assessment of individual sensitivity and repair capacity. Int J Radiat Oncol Biol Phys. 66:537–545. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zhang X, Aheli H, Zhang Z, Lv Y and Ge F: Association study on single nucleotide polymorphism in hOGG1, XRCC1, XRCC3 and radiosensitivity in esophageal cancer. J Xinjiang Med Univ. 33:473–476. 2010.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Luo Z, Yang L, Chen S, Chen C and Lin Z: The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma. Oncol Lett 11: 3508-3514, 2016.
APA
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., & Lin, Z. (2016). The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma. Oncology Letters, 11, 3508-3514. https://doi.org/10.3892/ol.2016.4384
MLA
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., Lin, Z."The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 11.5 (2016): 3508-3514.
Chicago
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., Lin, Z."The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 11, no. 5 (2016): 3508-3514. https://doi.org/10.3892/ol.2016.4384
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Luo Z, Yang L, Chen S, Chen C and Lin Z: The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma. Oncol Lett 11: 3508-3514, 2016.
APA
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., & Lin, Z. (2016). The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma. Oncology Letters, 11, 3508-3514. https://doi.org/10.3892/ol.2016.4384
MLA
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., Lin, Z."The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 11.5 (2016): 3508-3514.
Chicago
Zhang, Y., Luo, Z., Yang, L., Chen, S., Chen, C., Lin, Z."The association between four SNPs of X‑ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma". Oncology Letters 11, no. 5 (2016): 3508-3514. https://doi.org/10.3892/ol.2016.4384
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