Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience

  • Authors:
    • K. Ina Ly
    • Laura L. Crew
    • Carrie A. Graham
    • Maciej M. Mrugala
  • View Affiliations

  • Published online on: March 30, 2016     https://doi.org/10.3892/ol.2016.4393
  • Pages: 3471-3476
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Abstract

Rituximab (RTX) improves the outcome in patients with systemic diffuse large B‑cell lymphoma (DLBCL), but its benefit in primary central nervous system lymphoma (PCNSL) is unclear. In the present study, a single‑institution retrospective analysis was performed for 12 patients with newly diagnosed PCNSL treated with combined high‑dose methotrexate (HD‑MTX) and RTX. MTX was administered biweekly at 8 g/m2/dose until a complete response (CR) was achieved or for a maximum of eight doses. RTX was provided for a total of eight weekly doses at 375 mg/m2/dose. Following a median of 11 cycles of MTX, the radiographic overall response rate was 91% and the CR rate was 58%. A CR was achieved after a median 6 cycles of MTX. The median progression‑free survival time was 22 months and the median overall survival time has not yet been attained. These results compare favorably to single‑agent HD‑MTX and suggest a role for immunochemotherapy in the treatment of PCNSL.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ly KI, Crew LL, Graham CA and Mrugala MM: Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncol Lett 11: 3471-3476, 2016
APA
Ly, K.I., Crew, L.L., Graham, C.A., & Mrugala, M.M. (2016). Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncology Letters, 11, 3471-3476. https://doi.org/10.3892/ol.2016.4393
MLA
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11.5 (2016): 3471-3476.
Chicago
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11, no. 5 (2016): 3471-3476. https://doi.org/10.3892/ol.2016.4393