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Article

Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience

  • Authors:
    • K. Ina Ly
    • Laura L. Crew
    • Carrie A. Graham
    • Maciej M. Mrugala
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, University of Washington Medical Centre, Seattle, WA 98195, USA, Department of Neurological Surgery, University of Washington Medical Centre, Seattle, WA 98195, USA
  • Pages: 3471-3476
    |
    Published online on: March 30, 2016
       https://doi.org/10.3892/ol.2016.4393
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Abstract

Rituximab (RTX) improves the outcome in patients with systemic diffuse large B‑cell lymphoma (DLBCL), but its benefit in primary central nervous system lymphoma (PCNSL) is unclear. In the present study, a single‑institution retrospective analysis was performed for 12 patients with newly diagnosed PCNSL treated with combined high‑dose methotrexate (HD‑MTX) and RTX. MTX was administered biweekly at 8 g/m2/dose until a complete response (CR) was achieved or for a maximum of eight doses. RTX was provided for a total of eight weekly doses at 375 mg/m2/dose. Following a median of 11 cycles of MTX, the radiographic overall response rate was 91% and the CR rate was 58%. A CR was achieved after a median 6 cycles of MTX. The median progression‑free survival time was 22 months and the median overall survival time has not yet been attained. These results compare favorably to single‑agent HD‑MTX and suggest a role for immunochemotherapy in the treatment of PCNSL.
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1 

Villano JL, Koshy M, Shaikh H, Dolecek TA and McCarthy BJ: Age, gender and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer. 105:1414–1418. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Mead GM, Bleehen NM, Gregor A, Bullimore J, Shirley D, Rampling RP, Trevor J, Glaser MG, Lantos P, Ironside JW, et al: A medical research council randomized trial in patients with primary cerebral non-Hodgkin lymphoma: Cerebral radiotherapy with and without cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy. Cancer. 89:1359–1370. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Korfel A and Uschlegel: Diagnosis and treatment of primary CNS lymphoma. Nat Rev Neurol. 9:317–327. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Nelson DF, Martz KL, Bonner H, Nelson JS, Newall J, Kerman HD, Thomson JW and Murray KJ: Non-Hodgkin's lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the radiation therapy oncology group (RTOG): RTOG 8315. Int J Radiat Oncol Biol Phys. 23:9–17. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Laperriere NJ, Cerezo L, Milosevic MF, Wong CS, Patterson B and Panzarella T: Primary lymphoma of brain: Results of management of a modern cohort with radiation therapy. Radiother Oncol. 43:247–252. 1997. View Article : Google Scholar : PubMed/NCBI

6 

DeAngelis LM, Yahalom J, Thaler HT and Kher U: Combined modality therapy for primary CNS lymphoma. J Clin Oncol. 10:635–643. 1992.PubMed/NCBI

7 

Abrey LE, DeAngelis LM and Yahalom J: Long-term survival in primary CNS lymphoma. J Clin Oncol. 16:859–863. 1998.PubMed/NCBI

8 

Morris PG and Abrey LE: Therapeutic challenges in primary CNS lymphoma. Lancet Neurol. 8:581–592. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Omuro AM, Ben-Porat LS, Panageas KS, Kim AK, Correa DD, Yahalom J, Deangelis LM and Abrey LE: Delayed neurotoxicity in primary central nervous system lymphoma. Arch Neurol. 62:1595–1600. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Batchelor T, Carson K, O'Neill A, Grossman SA, Alavi J, New P, Hochberg F and Priet R: Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: A report of NABTT 96–07. J Clin Oncol. 21:1044–9. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Herrlinger U, Schabet M, Brugger W, Kortmann RD, Küker W, Deckert M, Engel C, Schmeck-Lindenau HJ, Mergenthaler HG, Krauseneck P, et al: German cancer society neuro-oncology working group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. Ann Neurol. 51:247–252. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Thiel E, Korfel A, Martus P, Kanz L, Griesinger F, Rauch M, Röth A, Hertenstein B, von Toll T, Hundsberger T, et al: High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): A phase 3, randomised, non-inferiority trial. Lancet Oncol. 11:1036–1047. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ferreri AJ, Reni M, Foppoli M, Martelli M, Pangalis GA, Frezzato M, Cabras MG, Fabbri A, Corazzelli G, Ilariucci F, et al: High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: A randomised phase 2 trial. Lancet. 374:1512–1520. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Chamberlain MC and Johnston SK: High-dose methotrexate and rituximab with deferred radiotherapy for newly diagnosed primary B-cell CNS lymphoma. Neuro Oncol. 12:736–744. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Birnbaum T, Stadler EA, von Baumgarten L and Straube A: Rituximab significantly improves complete response rate in patients with primary CNS lymphoma. J Neurooncol. 109:285–291. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Shah GD, Yahalom J, Correa DD, Lai RK, Raizer JJ, Schiff D, LaRocca R, Grant B, DeAngelis LM and Abrey LE: Combined immunochemotherapy with reduced whole-brain radiotherapy for newly diagnosed primary CNS lymphoma. J Clin Oncol. 25:4730–4735. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, et al: Immunochemotherapy with intensive consolidation for primary CNS lymphoma: A pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 18:1146–1155. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Fritsch K, Kasenda B, Hader C, Nikkhah G, Prinz M, Haug V, Haug S, Ihorst G, Finke J and Illerhaus G: Immunochemotherapy with rituximab, methotrexate, procarbazine and lomustine for primary CNS lymphoma (PCNSL) in the elderly. Ann Oncol. 22:2080–2085. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Filley CM and Kleinschmidt-DeMasters BK: Toxic leukoencephalopathy. N Engl J Med. 345:425–432. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Gavrilovic IT, Hormigo A, Yahalom J, DeAngelis LM and Abrey LE: Long-term follow-up of high-dose methotrexate-based therapy with and without whole brain irradiation for newly diagnosed primary CNS lymphoma. J Clin Oncol. 24:4570–4574. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Cang S, Mukhi N, Wang K and Liu D: Novel CD20 monoclonal antibodies for lymphoma therapy. J Hematol Oncol. 5:642012. View Article : Google Scholar : PubMed/NCBI

22 

Maloney DG, Grillo-López AJ, Bodkin DJ, White CA, Liles TM, Royston I, Varns C, Rosenberg J and Levy R: IDEC-C2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J Clin Oncol. 15:3266–3274. 1997.PubMed/NCBI

23 

Ruhstaller TW, Amsler U and Cerny T: Rituximab: Active treatment of central nervous system involvement by non-Hodgkin's lymphoma? Ann Oncol. 11:374–375. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Holdhoff M, Ambady P, Abdelaziz A, Sarai G, Bonekamp D, Blakeley J, Grossman SA and Ye X: High-dose methotrexate with or without rituximab in newly diagnosed primary CNS lymphoma. Neurology. 83:235–239. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Illerhaus G, Marks R, Müller F, Ihorst G, Feuerhake F, Deckert M, Ostertag C and Finke J: High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: Results of a prospective pilot and phase II study. Ann Oncol. 20:319–325. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Gerstner ER and Batchelo TT: Primary central nervous system lymphoma. Arch Neurol. 67:291–297. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Batchelor TT, Grossman SA, Mikkelsen T, Ye X, Desideri S and Lesser GJ: Rituximab monotherapy for patients with recurrent primary CNS lymphoma. Neurology. 76:929–930. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Wong ET, Tishler R, Barron L and Wu JK: Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas. Cancer. 101:139–145. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Enting RH, Demopoulos A, DeAngelis LM and Abrey LE: Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide. Neurology. 63:901–903. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ly KI, Crew LL, Graham CA and Mrugala MM: Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncol Lett 11: 3471-3476, 2016.
APA
Ly, K.I., Crew, L.L., Graham, C.A., & Mrugala, M.M. (2016). Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncology Letters, 11, 3471-3476. https://doi.org/10.3892/ol.2016.4393
MLA
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11.5 (2016): 3471-3476.
Chicago
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11, no. 5 (2016): 3471-3476. https://doi.org/10.3892/ol.2016.4393
Copy and paste a formatted citation
x
Spandidos Publications style
Ly KI, Crew LL, Graham CA and Mrugala MM: Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncol Lett 11: 3471-3476, 2016.
APA
Ly, K.I., Crew, L.L., Graham, C.A., & Mrugala, M.M. (2016). Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience. Oncology Letters, 11, 3471-3476. https://doi.org/10.3892/ol.2016.4393
MLA
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11.5 (2016): 3471-3476.
Chicago
Ly, K. I., Crew, L. L., Graham, C. A., Mrugala, M. M."Primary central nervous system lymphoma treated with high‑dose methotrexate and rituximab: A single‑institution experience". Oncology Letters 11, no. 5 (2016): 3471-3476. https://doi.org/10.3892/ol.2016.4393
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