Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

Wang,Shaozhong; Wu,Jian; Song,Yisa; Zhong,Huiling

doi:10.3892/ol.2016.4406

May-2016 Volume 11 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2016 Volume 11 Issue 5

Full Size Image

Article Open Access

Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

Authors:
- Shaozhong Wang
- Jian Wu
- Yisa Song
- Huiling Zhong
View Affiliations / Copyright

Affiliations: Otorhinolaryngology Department of Qinghai People's Hospital, Xining, Xining, Qinghai 810007, P.R. China, Department of Otolaryngology and Head and Neck Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China

Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3366-3368
|
Published online on: April 5, 2016

https://doi.org/10.3892/ol.2016.4406
Expand metrics +

Abstract

In recent years, the incidence of laryngeal carcinoma has been on the increase. The aim of the present study was to examine the expression level of endothelin-1 (ET-1) in laryngeal carcinoma tissues and to establish its clinical significance. A total of 82 cases of laryngeal carcinoma tissues were examined, of which 27 cases were stage I, 34 were stage II, and 21 were stage III. The normal mucosal tissues beyond the surgical incision margin in the 82 laryngeal carcinoma patients were used as the normal control. An additional 80 tissue specimens collected from laryngeal carcinoma outpatients were used as benign lesions. ET-1 expression levels in different tissues were determined using streptavidin-peroxidase (SP) immunohistochemistry. The results showed that the ET-1 expression level was highest in laryngeal carcinoma tissues and was significantly higher than that in the other two groups (P<0.05). The ET-1 expression level was higher in stage III compared to that in stage I and II (P<0.05) and higher than that of the normal control (P<0.05). The ET-1 expression level was higher in stage II compared to that in stage I (P<0.05). In conclusion, ET-1 was strongly expressed in laryngeal carcinoma tissues and may play an important role in the pathogenesis and development of laryngeal carcinoma tissues. ET-1 expression in laryngeal carcinoma tissues was associated with the clinical staging of laryngeal carcinoma.

View Figures

View References

1	Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, Palombo F, Viti V, Mesiti G, Zappulli V, et al: Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics. 10:1352009. View Article : Google Scholar : PubMed/NCBI
2	Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ and Maguire JJ: Endothelin. Pharmacol Rev. 68:357–418. 2016. View Article : Google Scholar : PubMed/NCBI
3	Flammer J and Konieczka K: Retinal venous pressure: The role of endothelin. EPMA J. 6:212015. View Article : Google Scholar : PubMed/NCBI
4	Li C, Sun Y and Liu B: The relationship between endothelin and tumor. Foreign Med Oncol Branch. 30:360–362. 2003.
5	Marchiano E, Chin OY, Fang CH, Park RC, Baredes S and Eloy JA: Laryngeal adenoid cystic carcinoma: A systematic review. Otolaryngol Head Neck Surg. 2154:433–439. 2016. View Article : Google Scholar
6	Rosanò Ll, Spinella F, Di Castro V, Nicotra MR, Dedhar S, de Herreros AG, Natali PG and Bagnato A: Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res. 65:11649–11657. 2005. View Article : Google Scholar : PubMed/NCBI
7	Chen MS, Yu WB, Fan YH, Zhanc XN and Ma LC: Detection of serum endothelin contents in patients with malignant tumors and its clinical significance. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 17:40–41. 2001.(In Chinese).
8	Tan H, Li L and Zhang S: The relationship between endothelin-1 and tumor angiogenesis. J Glob Tumor. 3:100–103. 2004.
9	Lien CC, Jiang JL, Jian DY, Kwok CF, Ho LT and Juan CC: Chronic endothelin-1 infusion causes adipocyte hyperplasia in rats. Obesity (Silver Spring). 24:643–653. 2016. View Article : Google Scholar : PubMed/NCBI
10	Qi HW, Ye JF, Song LQ, Chen WQ, Liang J and Mu DG: Exploration of serum endothelin-1 as a marker of early radiation lung injury. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 21:356–358. 2005.PubMed/NCBI
11	Xu D, Li Z, Wu B, et al: The expression of endothelin system in laryngocarcinoma cell HEP2. Proc Med Postgrad. 23:21–24. 2010.
12	Teng XJ, Shen ZX, Xiang JJ, Shen L, Yuan L, Guo J and Wang XL: Peripheral plasma Big endothelin 1 levels in patients with gastric carcinoma undergoing radical gastrectomy and its relationship with tumor recurrence. Zhonghua Wei Chang Wai Ke Za Zhi. 9:34–37. 2006.(In Chinese). PubMed/NCBI
13	Hagemann T, Binder C, Binder L, Pukrop T, Trümper L and Grimshaw MJ: Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells. DNA Cell Biol. 24:766–776. 2005. View Article : Google Scholar : PubMed/NCBI
14	Zhang J, Zhong W, Luo W and Zhang Z: Expression of Endothelin-1 in laryngeal carcinoma. J Clin Otolaryngol. 20:1124–1125. 2006.(In Chinese).

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

This article is mentioned in:

Abstract

Related Articles