Open Access

Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance

  • Authors:
    • Shaozhong Wang
    • Jian Wu
    • Yisa Song
    • Huiling Zhong
  • View Affiliations

  • Published online on: April 5, 2016     https://doi.org/10.3892/ol.2016.4406
  • Pages: 3366-3368
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, the incidence of laryngeal carcinoma has been on the increase. The aim of the present study was to examine the expression level of endothelin-1 (ET-1) in laryngeal carcinoma tissues and to establish its clinical significance. A total of 82 cases of laryngeal carcinoma tissues were examined, of which 27 cases were stage I, 34 were stage II, and 21 were stage III. The normal mucosal tissues beyond the surgical incision margin in the 82 laryngeal carcinoma patients were used as the normal control. An additional 80 tissue specimens collected from laryngeal carcinoma outpatients were used as benign lesions. ET-1 expression levels in different tissues were determined using streptavidin-peroxidase (SP) immunohistochemistry. The results showed that the ET-1 expression level was highest in laryngeal carcinoma tissues and was significantly higher than that in the other two groups (P<0.05). The ET-1 expression level was higher in stage III compared to that in stage I and II (P<0.05) and higher than that of the normal control (P<0.05). The ET-1 expression level was higher in stage II compared to that in stage I (P<0.05). In conclusion, ET-1 was strongly expressed in laryngeal carcinoma tissues and may play an important role in the pathogenesis and development of laryngeal carcinoma tissues. ET-1 expression in laryngeal carcinoma tissues was associated with the clinical staging of laryngeal carcinoma.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang S, Wu J, Song Y and Zhong H: Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance. Oncol Lett 11: 3366-3368, 2016
APA
Wang, S., Wu, J., Song, Y., & Zhong, H. (2016). Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance. Oncology Letters, 11, 3366-3368. https://doi.org/10.3892/ol.2016.4406
MLA
Wang, S., Wu, J., Song, Y., Zhong, H."Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance". Oncology Letters 11.5 (2016): 3366-3368.
Chicago
Wang, S., Wu, J., Song, Y., Zhong, H."Expression of endothelin-1 in laryngocarcinoma tissues and its clinical significance". Oncology Letters 11, no. 5 (2016): 3366-3368. https://doi.org/10.3892/ol.2016.4406