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The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells

  • Authors:
    • Yuho Maki
    • Yasumitsu Nishimura
    • Shinichi Toyooka
    • Junichi Soh
    • Kazunori Tsukuda
    • Kazuhiko Shien
    • Masashi Furukawa
    • Takayuki Muraoka
    • Tsuyoshi Ueno
    • Norimitsu Tanaka
    • Hiromasa Yamamoto
    • Hiroaki Asano
    • Megumi Maeda
    • Naoko Kumagai‑Takei
    • Suni Lee
    • Hidenori Matsuzaki
    • Takemi Otsuki
    • Shinichiro Miyoshi
  • View Affiliations / Copyright

    Affiliations: Department of General Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan
    Copyright: © Maki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3308-3316
    |
    Published online on: April 5, 2016
       https://doi.org/10.3892/ol.2016.4412
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Abstract

Malignant mesothelioma (MM) is thought to arise from the direct effect of asbestos on mesothelial cells. However, MM takes a long time to develop following exposure to asbestos, which suggests that the effects of asbestos are complex. The present study examined the effects of asbestos exposure on the cell growth of MeT-5A human mesothelial cells via cytokines produced by immune cells. Peripheral blood mononuclear cells (PBMCs) were stimulated with antibodies against cluster of differentiation (CD)3 and CD28 upon exposure to the asbestos chrysotile A (CA) or crocidolite (CR); the growth of MeT‑5A cells in media supplemented with PBMC culture supernatants was subsequently examined. MeT‑5A cells exhibited an increase in proliferation when grown in supernatant from the 7‑day PBMC culture exposed to CA or CR. Analysis of cytokine production demonstrated increased levels of granulocyte colony‑stimulating factor (G‑CSF), granulocyte-macrophage colony‑stimulating factor (GM‑CSF), interleukin (IL)‑1α, IL‑1β, IL‑3, IL‑5, IL‑13 and IL‑17A in supernatants. Individual administration of these cytokines, excluding G‑CSF and GM‑CSF, led to an increase in cell growth of MeT‑5A, whereas this effect was not observed following the combined administration of these cytokines. The results indicate that cytokines secreted by immune cells upon exposure to asbestos cause an increase in the growth activity of mesothelial cells, suggesting that alterations in the production of cytokines by immune cells may contribute to tumorigenesis in individuals exposed to asbestos.
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1 

Becklake MR, Bagatin E and Neder JA: Asbestos-related diseases of the lungs and pleura: Uses, trends and management over the last century. Int J Tuberc Lung Dis. 11:356–369. 2007.PubMed/NCBI

2 

Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Guha N, Freeman C, Galichet L and Cogliano V: WHO International Agency for Research on Cancer Monograph Working Group: A review of human carcinogen - Part C: Metals, arsenic, dusts, and fibres. Lancet Oncol. 10:453–454. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Upadhyay D and Kamp DW: Asbestos-induced pulmonary toxicity: Role of DNA damage and apoptosis. Exp Biol Med (Maywood). 228:650–659. 2003.PubMed/NCBI

4 

Lanphear BP and Buncher CR: Latent period for malignant mesothelioma of occupational origin. J Occup Med. 34:718–721. 1992.PubMed/NCBI

5 

Miura Y, Nishimura Y, Katsuyama H, Maeda M, Hayashi H, Dong M, Hyodoh F, Tomita M, Matsuo Y, Uesaka A, et al: Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells. Apoptosis. 11:1825–1835. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Murakami S, Nishimura Y, Maeda M, Kumagai N, Hayashi H, Chen Y, Kusaka M, Kishimoto T and Otsuki T: Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. Environ Health Prev Med. 14:216–222. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M, Nakano T, Fukuoka K, Kishimoto T, Hyodoh F, et al: Immunological effects of silica and asbestos. Cell Mol Immunol. 4:261–268. 2007.PubMed/NCBI

8 

Kumagai-Takei N, Nishimura Y, Maeda M, Hayashi H, Matsuzaki H, Lee S, Hiratsuka J and Otsuki T: Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 49:28–36. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Nishimura Y, Kumagai-Takei N, Matsuzaki H, Lee S, Maeda M, Kishimoto T, Fukuoka K, Nakano T and Otsuki T: Functional alteration of natural killer cells and cytotoxic T lymphocytes upon asbestos exposure and in malignant mesothelioma patients. BioMed Res Int. 2015:2384312015. View Article : Google Scholar : PubMed/NCBI

10 

Nishimura Y, Maeda M, Kumagai-Takei N, Lee S, Matsuzaki H, Wada Y, Nishiike-Wada T, Iguchi H and Otsuki T: Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases. Environ Health Prev Med. 18:198–204. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Nishimura Y, Maeda M, Kumagai-Takei N, Matsuzaki H, Lee S, Fukuoka K, Nakano T, Kishimoto T and Otsuki T: Effect of asbestos on anti-tumor immunity and immunological alteration in patients with mesothelioma. Malignant Mesothelioma. Belli C and Anand S: InTech. (Rijeka). 31–48. 2012.

12 

Miller J and Shukla A: The role of inflammation in development and therapy of malignant mesothelioma. Am Med J. 3:240–248. 2012. View Article : Google Scholar

13 

Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, et al: TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA. 103:10397–10402. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A and Hassan R: New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas. Am J Pathol. 182:1065–1077. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hillegass JM, Shukla A, Lathrop SA, MacPherson MB, Beuschel SL, Butnor KJ, Testa JR, Pass HI, Carbone M, Steele C and Mossman BT: Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model. Ann NY Acad Sci. 1203:7–14. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Kasuga I, Ishizuka S, Minemura K, Utsumi K, Serizawa H and Ohyashiki K: Malignant pleural mesothelioma produces functional granulocyte-colony stimulating factor. Chest. 119:981–983. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Maeda M, Miura Y, Nishimura Y, Murakami S, Hayashi H, Kumagai N, Hatayama T, Katoh M, Miyahara N, Yamamoto S, et al: Immunological changes in mesothelioma patients and their experimental detection. Clin Med Circ Respirat Pulm Med. 2:11–17. 2008.PubMed/NCBI

18 

Nakano T, Chahinian AP, Shinjo M, Tonomura A, Miyake M, Togawa N, Ninomiya K and Higashino K: Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural mesothelioma. Br J Cancer. 77:907–912. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Riddell SR and Greenberg PD: The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells. J Immunol Methods. 128:189–201. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Nishimura Y, Miura Y, Maeda M, Kumagai N, Murakami S, Hayashi H, Fukuoka K, Nakano T and Otsuki T: Impairment in cytotoxicity and expression of NK cell-activating receptors on human NK cells following exposure to asbestos fibers. Int J Immunopathol Pharmacol. 22:579–590. 2009.PubMed/NCBI

21 

Otsuki T, Hata H, Harada N, Matsuzaki H, Yata K, Wada H, Yawata Y, Ueki A and Yamada O: Cellular biological differences between human myeloma cell lines KMS-12-PE and KMS-12-BM established from a single patient. Int J Hematol. 72:216–222. 2000.PubMed/NCBI

22 

Dinarello CA: Proinflammatory cytokines. Chest. 118:503–508. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Rakoff-Nahoum S: Why cancer and inflammation? Yale J Biol Med. 79:123–130. 2006.PubMed/NCBI

25 

Hamilton RF Jr, Thakur SA and Holian A: Silica binding and toxicity in alveolar macrophages. Free Radic Biol Med. 44:1246–1258. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Multhoff G, Molls M and Radons J: Chronic inflammation in cancer development. Front Immunol. 2:982012. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Lee TC, Guillemin B, Yu MC and Rom WN: Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol. 150:4188–4196. 1993.PubMed/NCBI

28 

Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT and Tschopp J: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 320:674–677. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Franchi L, Eigenbrod T, Muñoz-Planillo R and Nuñez G: The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol. 10:241–247. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Alam R, Pazdrak K, Stafford S and Forsythe P: The lnterleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils. Int Arch Allergy Immunol. 107:226–227. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Sabo-Attwood T, Ramos-Nino M, Bond J, Butnor KJ, Heintz N, Gruber AD, Steele C, Taatjes DJ, Vacek P and Mossman BT: Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am J Pathol. 167:1243–1256. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Sabo-Attwood T, Ramos-Nino ME, Eugenia-Ariza M, Macpherson MB, Butnor KJ, Vacek PC, McGee SP, Clark JC, Steele C and Mossman BT: Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. Am J Pathol. 178:1975–1985. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Lee SJ, Lee EJ, Kim SK, Jeong P, Cho YH, Yun SJ, Kim S, Kim GY, Choi YH, Cha EJ, et al: Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; The roles of IL-5, IL-20, and IL-28A. PLoS One. 7:e402672012. View Article : Google Scholar : PubMed/NCBI

34 

Zurawski G and de Vries JE: Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today. 15:19–26. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Hamilton RF Jr, Holian A and Morandi MT: A comparison of asbestos and urban particulate matter in the in vitro modification of human alveolar macrophage antigen-presenting cell function. Exp Lung Res. 30:147–162. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Hillegass JM, Shukla A, MacPherson MB, Bond JP, Steele C and Mossman BT: Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1). J Toxicol Environ Health A. 73:423–436. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Takenouchi M, Hirai S, Sakuragi N, Yagita H, Hamada H and Kato K: Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts. Clin Cancer Res. 17:2819–2829. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Barderas R, Bartolomé RA, Fernandez-Aceñero MJ, Torres S and Casal JI: High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis and poor prognosis. Cancer Res. 72:2780–2790. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Kolls JK and Lindén A: Interleukin-17 family members and inflammation. Immunity. 21:467–476. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, et al: IL-17A-Producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol. 184:6367–6377. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A, Bruneval P, Fridman WH, Pagès F and Galon J: Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer. Cancer Res. 71:1263–1271. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Kryczek I, Wei S, Szeliga W, Vatan L and Zou W: Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood. 114:357–359. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Dodson RF, Williams MG Jr, Corn CJ, Brollo A and Bianchi C: A comparison of asbestos burden in lung parenchyma, lymph nodes, and plaques. Ann N Y Acad Sci. 643:53–60. 1991. View Article : Google Scholar : PubMed/NCBI

44 

Miserocchi G, Sancini G, Mantegazza F and Chiappino G: Translocation pathways for inhaled asbestos fibers. Environ Health. 7:42008. View Article : Google Scholar : PubMed/NCBI

45 

Lemaire I, Beaudoin H and Dubois C: Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis. Am Rev Respir Dis. 134:653–658. 1986.PubMed/NCBI

46 

Geist LJ, Powers LS, Monick MM and Hunninghake GW: Asbestos stimulation triggers differential cytokine release from human monocytes and alveolar macrophages. Exp Lung Res. 26:41–56. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Shurin MR, Lu L, Kalinski P, Stewart-Akers AM and Lotze MT: Th1/Th2 balance in cancer, transplantation and pregnancy. Springer Semin Immunopathol. 21:339–359. 1999. View Article : Google Scholar : PubMed/NCBI

48 

Lauerova L, Dusek L, Simickova M, Kocák I, Vagundová M, Zaloudík J and Kovarík J: Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response. Neoplasma. 49:159–166. 2002.PubMed/NCBI

49 

Pellegrini P, Berghella AM, Del Beato T, Cicia S, Adorno D and Casciani CU: Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother. 42:1–8. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Sato M, Goto S, Kaneko R, Ito M, Sato S and Takeuchi S: Impaired production of Th1 cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients. Anticancer Res. 18(5D): 3951–3955. 1998.PubMed/NCBI

51 

Schulze-Koops H and Kalden JR: The balance of Th1/Th2 cytokines in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 15:677–691. 2001. View Article : Google Scholar : PubMed/NCBI

52 

Kidd P: Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev. 8:223–246. 2003.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Maki Y, Nishimura Y, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Ueno T, Tanaka N, Tanaka N, et al: The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells. Oncol Lett 11: 3308-3316, 2016.
APA
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K. ... Miyoshi, S. (2016). The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells. Oncology Letters, 11, 3308-3316. https://doi.org/10.3892/ol.2016.4412
MLA
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K., Furukawa, M., Muraoka, T., Ueno, T., Tanaka, N., Yamamoto, H., Asano, H., Maeda, M., Kumagai‑Takei, N., Lee, S., Matsuzaki, H., Otsuki, T., Miyoshi, S."The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells". Oncology Letters 11.5 (2016): 3308-3316.
Chicago
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K., Furukawa, M., Muraoka, T., Ueno, T., Tanaka, N., Yamamoto, H., Asano, H., Maeda, M., Kumagai‑Takei, N., Lee, S., Matsuzaki, H., Otsuki, T., Miyoshi, S."The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells". Oncology Letters 11, no. 5 (2016): 3308-3316. https://doi.org/10.3892/ol.2016.4412
Copy and paste a formatted citation
x
Spandidos Publications style
Maki Y, Nishimura Y, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Ueno T, Tanaka N, Tanaka N, et al: The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells. Oncol Lett 11: 3308-3316, 2016.
APA
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K. ... Miyoshi, S. (2016). The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells. Oncology Letters, 11, 3308-3316. https://doi.org/10.3892/ol.2016.4412
MLA
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K., Furukawa, M., Muraoka, T., Ueno, T., Tanaka, N., Yamamoto, H., Asano, H., Maeda, M., Kumagai‑Takei, N., Lee, S., Matsuzaki, H., Otsuki, T., Miyoshi, S."The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells". Oncology Letters 11.5 (2016): 3308-3316.
Chicago
Maki, Y., Nishimura, Y., Toyooka, S., Soh, J., Tsukuda, K., Shien, K., Furukawa, M., Muraoka, T., Ueno, T., Tanaka, N., Yamamoto, H., Asano, H., Maeda, M., Kumagai‑Takei, N., Lee, S., Matsuzaki, H., Otsuki, T., Miyoshi, S."The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells". Oncology Letters 11, no. 5 (2016): 3308-3316. https://doi.org/10.3892/ol.2016.4412
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