Dermatomyositis as a symptom of primary lung cancer: A case report and review of the literature

Zhang,Xiangwei; Wang,Yang; Ma,Guoyuan; Zhang,Lin; Jing,Haiyan; Du,Jiajun

doi:10.3892/ol.2016.4418

May-2016 Volume 11 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2016 Volume 11 Issue 5

Full Size Image

Case Report

Dermatomyositis as a symptom of primary lung cancer: A case report and review of the literature

Authors:
- Xiangwei Zhang
- Yang Wang
- Guoyuan Ma
- Lin Zhang
- Haiyan Jing
- Jiajun Du
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China
Pages: 3413-3416
|
Published online on: April 7, 2016

https://doi.org/10.3892/ol.2016.4418
Expand metrics +

Abstract

Dermatomyositis (DM) is a rare autoimmune disease associated with manifestations of proximal muscle weakness and typical cutaneous skin rash. Patients with DM have a higher incidence rate of cancer, compared with the general population, since DM usually presents as a paraneoplastic syndrome. The present study reports a case of a 69‑year‑old male patient presenting with typical cutaneous rash and aggravating proximal muscle weakness for 3 months. When first admitted to the Department of Dermatology of Shandong Provincial Hospital Affiliated to Shandong University (Jinan, China), the patient was diagnosed with DM. Subsequently, chest computed tomography scan revealed a neoplasm located in the right upper lobe. Video‑assisted thoracoscopic surgery right upper lobectomy and lymph node dissection were then performed. The patient experienced a fast recovery from the surgery. The removal of the neoplasm clearly improved the symptoms of DM. Considering that DM is usually associated with the existence of a tumor, cases of DM require a thorough diagnostic investigation in order to exclude an underlying malignancy.

View Figures

View References

1	Mastaglia FL and Phillips BA: Idiopathic inflammatory myopathies: Epidemiology, classification, and diagnostic criteria. Rheum Dis Clin North Am. 28:723–741. 2002. View Article : Google Scholar : PubMed/NCBI
2	Dalakas MC and Hohlfeld R: Polymyositis and dermatomyositis. Lancet. 362:971–982. 2003. View Article : Google Scholar : PubMed/NCBI
3	Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR and Felson DT: Frequency of specific cancer types in dermatomyositis and polymyositis: A population-based study. Lancet. 357:96–100. 2001. View Article : Google Scholar : PubMed/NCBI
4	Callen JP: Relation between dermatomyositis and polymyositis and cancer. Lancet. 357:85–86. 2001. View Article : Google Scholar : PubMed/NCBI
5	Buchbinder R and Hill CL: Malignancy in patients with inflammatory myopathy. Curr Rheumatol Rep. 4:415–426. 2002. View Article : Google Scholar : PubMed/NCBI
6	Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar : PubMed/NCBI
7	Dalakas MC: Inflammatory disorders of muscle: Progress in polymyositis, dermatomyositis and inclusion body myositis. Curr Opin Neurol. 17:561–567. 2004. View Article : Google Scholar : PubMed/NCBI
8	Fathi M, Lundberg IE and Tornling G: Pulmonary complications of polymyositis and dermatomyositis. Semin Respir Crit Care Med. 28:451–458. 2007. View Article : Google Scholar : PubMed/NCBI
9	Dalakas MC: Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med. 325:1487–1498. 1991. View Article : Google Scholar : PubMed/NCBI
10	Miller FW, Rider LG, Plotz PH, Isenberg DA and Oddis CV: Diagnostic criteria for polymyositis and dermatomyositis. Lancet. 362:1762–1763. 2003. View Article : Google Scholar : PubMed/NCBI
11	Chow WH, Gridley G, Mellemkjaer L, McLaughlin JK, Olsen JH and Fraumeni JF Jr: Cancer risk following polymyositis and dermatomyositis: A nationwide cohort study in Denmark. Cancer Causes Control. 6:9–13. 1995. View Article : Google Scholar : PubMed/NCBI
12	Fujita J, Tokuda M, Bandoh S, Yang Y, Fukunaga Y, Hojo S, Ueda Y, Dobashi N, Dohmoto K, Ishida T and Takahara J: Primary lung cancer associated with polymyositis/dermatomyositis, with a review of the literature. Rheumatol Int. 20:81–84. 2001. View Article : Google Scholar : PubMed/NCBI
13	Andras C, Ponyi A and Constantin T: Dermatomyositis and polymyositis associated with malignancy: A 21-year retrospective study. J Rheumatol. 35:438–444. 2008.PubMed/NCBI
14	Zang YS, Xiu QY, Fang Z, Li B and Xia TB: Case report: Dramatic recovery of lung adenocarcinoma-associated dermatomyositis with targeted lung cancer therapy alone. Oncologist. 13:79–81. 2008. View Article : Google Scholar : PubMed/NCBI