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Article

Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood

  • Authors:
    • Kaida Huang
    • Yan Shen
    • Fengqi Zhang
    • Shanshan Wang
    • Xiao Wei
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 3477-3482
    |
    Published online on: April 7, 2016
       https://doi.org/10.3892/ol.2016.4423
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Abstract

The aim of the present study was to evaluate the effects of thymidylate synthase (TYMS) and excision repair cross-complementing 1 (ERCC1) polymorphisms on chemotherapeutic efficacy in patients with gastrointestinal tumors using peripheral venous blood. Preoperative peripheral venous blood and tumor tissue samples of 43 patients with gastric cancer and the peripheral venous blood samples of 76 patients with cancer who underwent chemotherapy were studied. The 3R/3R and 2R/2R or 2R/3R genotypes of TYMS were identified in 72.09 and 27.91%, respectively (P<0.01), of untreated patients, and the C/C and T/T or C/T genotypes of ERCC1 were present in 81.39 and 18.61%, respectively (P<0.01), of patients. The 3R/3R and 2R/2R or 2R/3R genotypes of TYMS were identified in 65.79 and 34.21%, respectively, of chemotherapy‑treated patients. The overall response rates (ORRs) for the two aforementioned genotypes were 18.00 and 57.69%, respectively (P<0.01), and those for the C/C and T/T or C/T genotypes of ERCC1 were 63.16 and 36.84%, respectively. The ORRs were 47.91 and 3.57%, respectively (P<0.01). In conclusion, peripheral blood samples may be used to replace tumor tissue for detecting TYMS and ERCC1 polymorphisms, and may be used to evaluate the efficacy of 5-fluorouracil and platinum drugs.
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1 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Carrato A, Gallego-Plazas J and Guillen-Ponce C: Adjuvant therapy of resected gastric cancer is necessary. Semin Oncol. 32(6 Suppl 9): S105–S108. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Kalow W, Tang BK and Endrenyi L: Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics. 8:283–289. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Adleff V, Hitre E, Köves L, Orosz Z, Hajnal A and Kralovánszky J: Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients. Int J Cancer. 108:852–856. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Graziano F, Kawakami K, Watanabe G, Ruzzo A, Humar B, Santini D, Catalano V, Ficarelli R, Merriman T, Panunzi S, et al: Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. Int J Cancer. 112:1010–1014. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Mandola MV, Stoehlmaeher J, Zhang W, Groshen S, Yu MC, Iqbal S, Lenz HJ and Ladner RD: A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogeneties. 14:319–327. 2004. View Article : Google Scholar

7 

Chen J, Hunter DJ, Stampfer MJ, Kyte C, Chan W, Wetmur JG, Mosig R, Selhub J and Ma J: Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 12:958–962. 2003.PubMed/NCBI

8 

Cascinu S, Aschele C, Barni S, Debernardis D, Baldo C, Tunesi G, Catalano V, Staccioli MP, Brenna A, Muretto P and Catalano G: Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil. Clin Cancer Res. 5:1996–1999. 1999.PubMed/NCBI

9 

Davies MM, Johnston PG, Kaur S and Allen-Mersh TG: Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine. Clin Cancer Res. 5:325–328. 1999.PubMed/NCBI

10 

Raymond E, Faivre S, Woynarowski JM and Chaney SG: Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol. 25(2 Suppl 5): S4–S12. 1998.

11 

Altaha R, Liang X, Yu JJ and Reed E: Excision repair cross complementing group 1: gene expression and platinum resistance. Int J Mol Med. 14:959–970. 2004.PubMed/NCBI

12 

Yin M, Yan J, Martinez-Balibrea E, Graziano F, Lenz HJ, Kim HJ, Robert J, Im SA, Wang WS, Etienne-Grimaldi MC and Wei Q: ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. Clin Cancer Res. 17:1632–1640. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Yin M, Yan J, Martinez-Balibrea E, Graziano F, Lenz HJ, Kim HJ, Robert J, Im SA, Wang WS, Etienne-Grimaldi MC and Wei Q: ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: A systemic review and meta-analysis. Clin Cancer Res. 17:1632–1640. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Brody JR, Hucl T, Gallmeier E, Winter JM, Kern SE and Murphy KM: Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy. Cancer Res. 66:9369–9373. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Watson RG, Muhale F, Thorne LB, Yu J, O'Neil BH, Hoskins JM, Meyers MO, Deal AM, Ibrahim JG, Hudson ML, et al: Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy. Eur J Cancer. 46:3358–3364. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Morganti M, Ciantelli M, Giglioni B, Putignano AL, Nobili S, Papi L, Landini I, Napoli C, Valanzano R, Cianchi F, et al: Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers. Eur J Cancer. 41:2176–2183. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Yawata A, Kim SR, Miyajima A, Kubo T, Ishida S, Saito Y, Nakajima Y, Katori N, Matsumoto Y, Fukuoka M, et al: Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents. Cancer Chemother Pharmacol. 56:465–472. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Huang ZH, Hua D and Li LH: The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population. Cancer Chemother Pharmacol. 63:911–918. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Cui YH, Liu TS, Zhuang RY, Gao HJ and Li H: Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer. J Dig Dis. 10:118–123. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Villafranca E, Okruzhnov Y, Dominguez MA, García-Foncillas J, Azinovic I, Martínez E, Illarramendi JJ, Arias F, Martínez Monge R, Salgado E, et al: Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol. 19:1779–1786. 2001.PubMed/NCBI

21 

Pullarkat ST, Stoehlmacher J, Ghaderi V, Xiong YP, Ingles SA, Sherrod A, Warren R, Tsao-Wei D, Groshen S and Lenz HJ: Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 1:65–70. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Marsh S, McKay JA, Cassidy J and McLeod HL: Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol. 19:383–386. 2001.PubMed/NCBI

23 

Park DJ, Stoehlmacher J, Zhang W, Tsao-Wei D, Groshen S and Lenz HJ: Thymidylate synthasegene polymorphism predicts response to capecitabine in advanced colorectal cancer. Int J Colorectal Dis. 17:46–49. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Matasui T, Omura K, Kawakami K, Morita S and Sakamoto J: Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncol Rep. 16:1111–1115. 2006.PubMed/NCBI

25 

Kakimoto M, Uetake H, Osanai T, Shirota Y, Takagi Y, Takeshita E, Toriya Y, Danenberg K, Danenberg PV and Sugihara K: Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test. Cancer Lett. 223:103–111. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM and Potter JD: Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev. 9:1381–1385. 2000.PubMed/NCBI

27 

Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ and Ladner RD: A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF1 binding and alters transcriptional activity. Cancer Res. 63:2898–2904. 2003.PubMed/NCBI

28 

Ulrich CM, Bigler J, Bostick R, Fosdick L and Potter JD: Thymidylate synthase promoter polymorphism interaction with folate intake and risk of colorectal adenomas. Cancer Res. 62:3361–3364. 2002.PubMed/NCBI

29 

Won DY, Kim SH, Hur H, Jung H and Jeon HM: Chemotherapeutic responsibility according to polymorphism of ERCC1, XRCC1 and GSPT1 in gastric cancer patients receiving oxaliplatin based chemotherapy. J Korean Surg Soc. 8:350–356. 2010. View Article : Google Scholar

30 

Liu YP, Ling Y, Zhang YP and Liu BR: Predictive values of platinum related gene polymorphisms in gastric cancer patients on oxaliplatin-based adjuvant chemotherapy. Zhonghua Yi Xue Za Zhi. 91:256–259. 2011.(In Chinese). PubMed/NCBI

31 

Ruzzo A, Graziano F, Kawakami K, Watanabe G, Santini D, Catalano V, Bisonni R, Canestrari E, Ficarelli R, Menichetti ET, et al: Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy. J Clin Oncol. 24:1883–1891. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Ruzzo A, Graziano F, Loupakis F, Rulli E, Canestrari E, Santini D, Catalano V, Ficarelli R, Maltese P, Bisonni R, et al: Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy. J Clin Oncol. 25:1247–1254. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Viguier J, Boige V, Miquel C, Pocard M, Giraudeau B, Sabourin JC, Ducreux M, Sarasin A and Praz F: ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin Cancer Res. 11:6212–6217. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang K, Shen Y, Zhang F, Wang S and Wei X: Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood. Oncol Lett 11: 3477-3482, 2016.
APA
Huang, K., Shen, Y., Zhang, F., Wang, S., & Wei, X. (2016). Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood. Oncology Letters, 11, 3477-3482. https://doi.org/10.3892/ol.2016.4423
MLA
Huang, K., Shen, Y., Zhang, F., Wang, S., Wei, X."Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood". Oncology Letters 11.5 (2016): 3477-3482.
Chicago
Huang, K., Shen, Y., Zhang, F., Wang, S., Wei, X."Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood". Oncology Letters 11, no. 5 (2016): 3477-3482. https://doi.org/10.3892/ol.2016.4423
Copy and paste a formatted citation
x
Spandidos Publications style
Huang K, Shen Y, Zhang F, Wang S and Wei X: Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood. Oncol Lett 11: 3477-3482, 2016.
APA
Huang, K., Shen, Y., Zhang, F., Wang, S., & Wei, X. (2016). Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood. Oncology Letters, 11, 3477-3482. https://doi.org/10.3892/ol.2016.4423
MLA
Huang, K., Shen, Y., Zhang, F., Wang, S., Wei, X."Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood". Oncology Letters 11.5 (2016): 3477-3482.
Chicago
Huang, K., Shen, Y., Zhang, F., Wang, S., Wei, X."Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood". Oncology Letters 11, no. 5 (2016): 3477-3482. https://doi.org/10.3892/ol.2016.4423
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