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Article

An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas

  • Authors:
    • Roberto Betti
    • Elena Agape
    • Raffaella Vergani
    • Laura Moneghini
    • Amilcare Cerri
  • View Affiliations / Copyright

    Affiliations: Dermatology Clinic, Department of Health Sciences, University of Milan, Hospital San Paolo, 20142 Milan, Italy, Division of Pathology, Department of Health Sciences, University of Milan, Hospital San Paolo, 20142 Milan, Italy
  • Pages: 2099-2102
    |
    Published online on: July 5, 2016
       https://doi.org/10.3892/ol.2016.4813
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Abstract

The natural history of superficial spreading melanomas (SSMs) involves the progression from a radial growth phase (RGP) to a vertical growth phase (VGP). Currently, a patient's history represents the only method to estimate the rate of tumor growth. The present study aimed to verify whether the estimated rate of growth (ROG) of SSMs with a RGP or VGP exhibited any differences, and to evaluate the possible implications for the most important prognostic determinants. ROG was quantified as the ratio between Breslow's thickness in millimeters (mm) and the time of tumor growth in months, defined as the time between the date that the patient had first noticed the lesion in which melanoma subsequently developed and the date on which the patient first felt this lesion changed. A total of 105 patients (58 male and 47 female) were studied. Of these, 66 had VGP‑SSMs, whilst 39 had RGP‑only SSMs (RGP‑SSMs). No significant differences in age and gender were observed between these groups. The mean Breslow's thickness in patients with VGP-SSMs was significantly greater than in patients with RGP‑SSMs (0.78±0.68 vs. 0.48±0.22 mm, P=0.0096). Similarly, the ROG was observed to be higher in VGP-SSM vs. RGP-SSM patients (0.13±0.16 vs. 0.065±0.09 mm/month, P=0.0244). In patients with VGP‑SSMs, Breslow's thickness and ROG were significantly higher for tumors with a mitotic rate of ≥1 mitosis/mm2 compared with those with <1 mitosis/mm2 (1.15±0.96 vs. 0.56±0.30 mm, P=0.0005; and 0.188±0.20 vs. 0.09±0.12 mm/month, P=0.0228, respectively). According to these results, two subsets of SSMs exist: The first is characterized by the presence of mitosis and a higher ROG, while the second exhibits a more indolent behavior and is characterized by an RGP only. Given the differences in the Breslow's thickness and ROG, clinicians must be aware of the possible diagnostic delay in these subsets of melanoma that, differently from true nodular melanomas, generally fulfill the classical ABCD clinical criteria.
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Copy and paste a formatted citation
Spandidos Publications style
Betti R, Agape E, Vergani R, Moneghini L and Cerri A: An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas. Oncol Lett 12: 2099-2102, 2016.
APA
Betti, R., Agape, E., Vergani, R., Moneghini, L., & Cerri, A. (2016). An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas. Oncology Letters, 12, 2099-2102. https://doi.org/10.3892/ol.2016.4813
MLA
Betti, R., Agape, E., Vergani, R., Moneghini, L., Cerri, A."An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas". Oncology Letters 12.3 (2016): 2099-2102.
Chicago
Betti, R., Agape, E., Vergani, R., Moneghini, L., Cerri, A."An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas". Oncology Letters 12, no. 3 (2016): 2099-2102. https://doi.org/10.3892/ol.2016.4813
Copy and paste a formatted citation
x
Spandidos Publications style
Betti R, Agape E, Vergani R, Moneghini L and Cerri A: An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas. Oncol Lett 12: 2099-2102, 2016.
APA
Betti, R., Agape, E., Vergani, R., Moneghini, L., & Cerri, A. (2016). An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas. Oncology Letters, 12, 2099-2102. https://doi.org/10.3892/ol.2016.4813
MLA
Betti, R., Agape, E., Vergani, R., Moneghini, L., Cerri, A."An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas". Oncology Letters 12.3 (2016): 2099-2102.
Chicago
Betti, R., Agape, E., Vergani, R., Moneghini, L., Cerri, A."An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas". Oncology Letters 12, no. 3 (2016): 2099-2102. https://doi.org/10.3892/ol.2016.4813
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