Proteomic profile of saliva and plasma from women with impalpable breast lesions

  • Authors:
    • Lucas Delmonico
    • Maryah Bravo
    • Rafaele Tavares Silvestre
    • Maria Helena Faria Ornellas
    • Carolina Maria De Azevedo
    • Gilda Alves
  • View Affiliations

  • Published online on: July 8, 2016     https://doi.org/10.3892/ol.2016.4828
  • Pages: 2145-2152
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Abstract

The present study evaluated the proteomic profile of saliva and plasma from women with impalpable breast lesions using nano-liquid chromatography-quadrupole-time-of-flight (nLC-Q-TOF) technology. Plasma and saliva from patients with fibroadenoma (n=10), infiltrating ductal carcinoma (n=10) and healthy control groups (n=8) were assessed by combinations of inter/intra‑group analyses, revealing significant quantitative and qualitative differences. The major differentially-expressed proteins in the saliva of patients compared with the controls were α2-macroglobulin and ceruloplasmin, but the proteins that met the minimum fold‑change and P‑value cut‑offs were leukocyte elastase inhibitor and α‑enolase, and deleted in malignant brain tumors 1. Concerning plasma, α-2-macroglobulin and ceruplasmin were upregulated, while other proteins such as haptoglobin, hemopexin and vitamin D‑binding protein were downregulated compared with the control. The changes in immune, molecular transport and signaling pathways were the most representative in the proteomic profile of the saliva and plasma. This is the first study to describe the proteome of saliva and plasma from the same women with impalpable breast lesions.
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September-2016
Volume 12 Issue 3

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Spandidos Publications style
Delmonico L, Bravo M, Silvestre RT, Ornellas MH, De Azevedo CM and Alves G: Proteomic profile of saliva and plasma from women with impalpable breast lesions. Oncol Lett 12: 2145-2152, 2016
APA
Delmonico, L., Bravo, M., Silvestre, R.T., Ornellas, M.H., De Azevedo, C.M., & Alves, G. (2016). Proteomic profile of saliva and plasma from women with impalpable breast lesions. Oncology Letters, 12, 2145-2152. https://doi.org/10.3892/ol.2016.4828
MLA
Delmonico, L., Bravo, M., Silvestre, R. T., Ornellas, M. H., De Azevedo, C. M., Alves, G."Proteomic profile of saliva and plasma from women with impalpable breast lesions". Oncology Letters 12.3 (2016): 2145-2152.
Chicago
Delmonico, L., Bravo, M., Silvestre, R. T., Ornellas, M. H., De Azevedo, C. M., Alves, G."Proteomic profile of saliva and plasma from women with impalpable breast lesions". Oncology Letters 12, no. 3 (2016): 2145-2152. https://doi.org/10.3892/ol.2016.4828