Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report

  • Authors:
    • Feng Shi
    • Quan Zhou
    • Ying Gao
    • Xiang‑Qing Cui
    • Hong Chang
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  • Published online on: July 11, 2016     https://doi.org/10.3892/ol.2016.4840
  • Pages: 1925-1928
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Abstract

B-cell lymphoma (BCL), unclassifiable, with features intermediate between diffuse large BCL (DLBCL) and classical Hodgkin's lymphoma (CHL), is a novel entity to the World Health Organization classification system. These tumors are rare aggressive lymphomas that have a poor prognosis. The present study reports the case of a patient with one such lymphoma that occurred in the spleen, which expressed cluster of differentiation (CD)20, CD79α, melanoma associated antigen (mutated) 1, BCL6, CD15 and CD30. Polymerase chain reaction analysis demonstrated a clonal rearrangement of the genes coding for immunoglobulin heavy chains. The tumor cells demonstrated a negative reaction in the Epstein-Barr virus-encoded small RNA assay. Following the diagnosis of unclassifiable BCL, with intermediate features between DLBCL and CHL, the patient received 7 cycles of the CHOP regimen, and so far, has been in good general condition and tumor-free for 17 months.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shi F, Zhou Q, Gao Y, Cui XQ and Chang H: Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report. Oncol Lett 12: 1925-1928, 2016.
APA
Shi, F., Zhou, Q., Gao, Y., Cui, X., & Chang, H. (2016). Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report. Oncology Letters, 12, 1925-1928. https://doi.org/10.3892/ol.2016.4840
MLA
Shi, F., Zhou, Q., Gao, Y., Cui, X., Chang, H."Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report". Oncology Letters 12.3 (2016): 1925-1928.
Chicago
Shi, F., Zhou, Q., Gao, Y., Cui, X., Chang, H."Primary splenic B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report". Oncology Letters 12, no. 3 (2016): 1925-1928. https://doi.org/10.3892/ol.2016.4840