Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma

  • Authors:
    • Ming Li
    • Fang Deng
    • Li‑Ting Qian
    • Shui‑Ping Meng
    • Yang Zhang
    • Wu‑Lin Shan
    • Xiao‑Lei Zhang
    • Bao‑Long Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, P.R. China, Department of Clinical Laboratory, Anhui Provincial Cancer Hospital, Hefei, Anhui 230031, P.R. China, Department of Respiratory Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230031, P.R. China
  • Pages: 1953-1958
    |
    Published online on: July 12, 2016
       https://doi.org/10.3892/ol.2016.4847
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have demonstrated an association between human papillomavirus (HPV) and mutations in the epidermal growth factor receptor (EGFR) gene in lung cancer patients; however, few studies have investigated this association in advanced lung adenocarcinoma patients undergoing gefitinib treatment. The present study investigated the association between HPV and EGFR mutations in advanced lung adenocarcinoma patients. A total of 95 advanced lung adenocarcinoma patients were enrolled in the study. The HPV infection status and presence of EGFR mutations in tumor tissue was evaluated. Patient clinical characteristics were also determined and compared with HPV infection and EGFR mutation status to analyze their impact on progression‑free survival. HPV DNA was identified in 27/95 (28.4%) lung adenocarcinoma tumors and was most common in patients with lymph node metastasis (P=0.016). A total of 44/95 (46.3%) cases exhibited EGFR mutations, which were predominantly observed in female patients and non‑smokers. The presence of HPV DNA was significantly associated with EGFR mutations (P=0.012) and multivariate analysis also revealed that HPV DNA was significantly associated with EGFR mutations (odds ratio=3.971) in advanced lung adenocarcinoma. Patients with both HPV infections and EGFR mutations exhibit a marked decrease in the risk of lung cancer progression when compared with those without HPV infection or EGFR mutations (adjusted HR=0.640; 95% confidence interval: 0.488‑0.840; P=0.001). HPV infection was significantly associated with EGFR mutations in advanced lung adenocarcinoma patients. Furthermore, patients with HPV infections exhibited the longest progression-free survival times, which may be due to good response to tyrosine kinase inhibitor‑ or platinum‑based‑adjuvant therapy in these patients. Patients with EGFR mutations exhibited a better prognosis when compared with those exhibiting wild-type EGFR, regardless of HPV status.
View Figures

Figure 1

Figure 2

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Thun MJ, Hannan LM, Adams-Campbell LL, Boffetta P, Buring JE, Feskanich D, Flanders WD, Jee SH, Katanoda K, Kolonel LN, et al: Lung cancer occurrence in never-smokers: An analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 5:e1852008. View Article : Google Scholar : PubMed/NCBI

3 

Klein F, Amin Kotb WF and Petersen I: Incidence of human papilloma virus in lung cancer. Lung Cancer. 65:13–18. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Yanagawa N, Wang A, Kohler D, Santos Gda C, Sykes J, Xu J, Pintilie M and Tsao MS: Human papilloma virus genome is rare in North American non-small cell lung carcinoma patients. Lung Cancer. 79:215–220. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Sagerup CM, Nymoen DA, Halvorsen AR, Lund-Iversen M, Helland A and Brustugun OT: Human papilloma virus detection and typing in 334 lung cancer patients. Acta Oncol. 53:952–957. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Sarchianaki E, Derdas SP, Ntaoukakis M, Vakonaki E, Lagoudaki ED, Lasithiotaki I, Sarchianaki A, Koutsopoulos A, Symvoulakis EK, Spandidos DA, et al: Detection and genotype analysis of human papillomavirus in non-small cell lung cancer patients. Tumour Biol. 35:3203–3209. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Anantharaman D, Gheit T, Waterboer T, Halec G, Carreira C, Abedi-Ardekani B, McKay-Chopin S, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, et al: No causal association identified for human papillomavirus infections in lung cancer. Cancer Res. 74:3525–3534. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Simen-Kapeu A, Surcel HM, Koskela P, Pukkala E and Lehtinen M: Lack of association between human papillomavirus type 16 and 18 infections and female lung cancer. Cancer Epidemiol Biomarkers Prev. 19:1879–1881. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M and Kawaguchi T: Human papilloma virus in non-small cell lung cancer in never smokers: A systematic review of the literature. Lung Cancer. 83:8–13. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Baba M, Castillo A, Koriyama C, Yanagi M, Matsumoto H, Natsugoe S, Shuyama KY, Khan N, Higashi M, Itoh T, et al: Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas. Oncol Rep. 23:1085–1092. 2010.PubMed/NCBI

11 

Tung MC, Wu HH, Cheng YW, Wang L, Chen CY, Yeh SD, Wu TC and Lee H: Association of epidermal growth factor receptor mutations with human papillomavirus 16/18 E6 oncoprotein expression in non-small cell lung cancer. Cancer. 119:3367–3376. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Kato T, Koriyama C, Khan N, Samukawa T, Yanagi M, Hamada T, Yokomakura N, Otsuka T, Inoue H, Sato M, et al: EGFR mutations and human papillomavirus in lung cancer. Lung Cancer. 78:144–147. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wood DE, Kazerooni E, Baum SL, Dransfield MT, Eapen GA, Ettinger DS, Hou L, Jackman DM, Klippenstein D, Kumar R, et al: Lung cancer screening, version 1.2015: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 13:23–34. 2015.PubMed/NCBI

14 

Wei W, Shi Q, Guo F, Zhang BY, Chen C, Zhang NS and Dong XP: The distribution of human papillomavirus in tissues from patients with head and neck squamous cell carcinoma. Oncol Rep. 28:1750–1756. 2012.PubMed/NCBI

15 

Zhou Q, Zhang XC, Chen ZH, Yin XL, Yang JJ, Xu CR, Yan HH, Chen HJ, Su J, Zhong WZ, et al: Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer. J Clin Oncol. 29:3316–3321. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Syrjänen K: Detection of human papillomavirus in lung cancer: Systematic review and meta-analysis. Anticancer Res. 32:3235–3250. 2012.PubMed/NCBI

17 

Ragin C, Obikoya-Malomo M, Kim S, Chen Z, Flores-Obando R, Gibbs D, Koriyama C, Aguayo F, Koshiol J, Caporaso NE, et al: HPV-associated lung cancers: An international pooled analysis. Carcinogenesis. 35:1267–1275. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wang JL, Fang CL, Wang M, Yu MC, Bai KJ, Lu PC and Liu HE: Human papillomavirus infections as a marker to predict overall survival in lung adenocarcinoma. Int J Cancer. 134:65–71. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Cheng YW, Chiou HL, Sheu GT, Hsieh LL, Chen JT, Chen CY, Su JM and Lee H: The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res. 61:2799–2803. 2001.PubMed/NCBI

20 

Pallis AG and Syrigos KN: Lung cancer in never smokers: Disease characteristics and risk factors. Crit Rev Oncol Hematol. 88:494–503. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Mitsudomi T, Kosaka T and Yatabe Y: Biological and clinical implications of EGFR mutations in lung cancer. Int J Clin Oncol. 11:190–198. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 97:339–346. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science. 304:1497–1500. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Hsu NY, Cheng YW, Chan IP, Ho HC, Chen CY, Hsu CP, Lin MH and Chou MC: Association between expression of human papillomavirus 16/18 E6 oncoprotein and survival in patients with stage I non-small cell lung cancer. Oncol Rep. 21:81–87. 2009.PubMed/NCBI

25 

Márquez-Medina D, Gasol-Cudós A, Taberner-Bonastre MT, Samamé Pérez-Vargas JC, Salud-Salvia A and Llombart-Cussac A: Human papillomavirus in non-small-cell lung cancer: The impact of EGFR mutations and the response to erlotinib. Arch Bronconeumol. 49:79–81. 2013.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

26 

Wu HH, Wu JY, Cheng YW, Chen CY, Lee MC, Goan YG and Lee H: cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Clin Cancer Res. 16:5200–5210. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Zhang E, Feng X, Liu F, Zhang P, Liang J and Tang X: Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells. PLoS One. 9:e1034402014. View Article : Google Scholar : PubMed/NCBI

28 

Sung WW and Lee H: The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma. Oncoimmunology. 2:e258542013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li M, Deng F, Qian LT, Meng SP, Zhang Y, Shan WL, Zhang XL and Wang BL: Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma. Oncol Lett 12: 1953-1958, 2016.
APA
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W. ... Wang, B. (2016). Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma. Oncology Letters, 12, 1953-1958. https://doi.org/10.3892/ol.2016.4847
MLA
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W., Zhang, X., Wang, B."Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma". Oncology Letters 12.3 (2016): 1953-1958.
Chicago
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W., Zhang, X., Wang, B."Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma". Oncology Letters 12, no. 3 (2016): 1953-1958. https://doi.org/10.3892/ol.2016.4847
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Deng F, Qian LT, Meng SP, Zhang Y, Shan WL, Zhang XL and Wang BL: Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma. Oncol Lett 12: 1953-1958, 2016.
APA
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W. ... Wang, B. (2016). Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma. Oncology Letters, 12, 1953-1958. https://doi.org/10.3892/ol.2016.4847
MLA
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W., Zhang, X., Wang, B."Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma". Oncology Letters 12.3 (2016): 1953-1958.
Chicago
Li, M., Deng, F., Qian, L., Meng, S., Zhang, Y., Shan, W., Zhang, X., Wang, B."Association between human papillomavirus and EGFR mutations in advanced lung adenocarcinoma". Oncology Letters 12, no. 3 (2016): 1953-1958. https://doi.org/10.3892/ol.2016.4847
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team