Possible intrinsic association of anti-neutrophil cytoplasmic antibody-associated vasculitis coexisting with multiple myeloma

Liu,Huifang; Xiong,Jiachuan; Zhang,Jun; Zhang,Ying; Nie,Ling; Wang,Yiqin; Zhao,Jinghong

doi:10.3892/ol.2016.4855

September-2016 Volume 12 Issue 3

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September-2016 Volume 12 Issue 3

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Article

Possible intrinsic association of anti-neutrophil cytoplasmic antibody-associated vasculitis coexisting with multiple myeloma

Authors:
- Huifang Liu
- Jiachuan Xiong
- Jun Zhang
- Ying Zhang
- Ling Nie
- Yiqin Wang
- Jinghong Zhao
View Affiliations / Copyright

Affiliations: Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of the People's Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
Pages: 2084-2086
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Published online on: July 13, 2016

https://doi.org/10.3892/ol.2016.4855
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Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a life‑threatening condition that causes renal failure. Multiple myeloma (MM) is a malignant proliferation of monoclonal plasma cells in the blood that can also cause renal failure. The two diseases have high morbidity and mortality rates in the elderly, with a poor prognosis. A 64-year-old female presented to Xinqiao Hospital (Chonqing, China) with fatigue and a poor appetite that had been apparent for 6 weeks. Laboratory tests revealed a serum creatinine level of 10.31 mg/dl, a cytoplasmic ANCA titer of 1:10, a positive result for myeloperoxidase and a serum globulin level of 3.96 g/dl. A renal biopsy revealed crescent glomerulonephritis, combined with the rapid progression of renal function. Based on these observations (ANCA titer, crescent glomerulonephritis and rapid progression of renal function) a diagnosis of AAV was established. MM was confirmed by serum immunofixation electrophoresis combined with bone marrow aspiration. The present study discusses what is, to the best of our knowledge, the first case of AAV coexisting with MM in order to highlight it as a clinical concern.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Possible intrinsic association of anti-neutrophil cytoplasmic antibody-associated vasculitis coexisting with multiple myeloma

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