Open Access

Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A

  • Authors:
    • Wei Wang
    • Jinjing Jia
    • Changji Li
    • Qiqi Duan
    • Jiao Yang
    • Xin Wang
    • Ruilian Li
    • Caifeng Chen
    • Huling Yan
    • Yan Zheng
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/ol.2016.4865
  • Pages: 1745-1752
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The antimicrobial peptide LL-37 not only contributes to the host defence against microbial invasion but also regulates immune activity, angiogenesis and cell proliferation. Studies have shown that LL-37 participates in the development of a variety of tumours, such as lung cancer, ovarian cancer, breast cancer and melanoma. However, the role of LL‑37 in the development of skin squamous cell carcinoma (SCC) is not clear. The present study used immunohistochemistry to confirm that the expression of human DNA‑binding protein A (dbpA) was increased in SCC tissues. After stimulating SCC A341 cells, LL-37 was shown promote the proliferation, migration and invasion of these malignant cells. LL-37 also promoted the upregulation of dbpA mRNA and protein expression. In addition, after using small interfering RNA to silence the normal dbpA expression in these malignant cells, the proliferation and invasion of the tumor cells were significantly reduced. When the NF-κB inhibitor PDTC was used to inhibit the process of LL-37‑stimulated cells, it was found that the original upregulated expression of dbpA was downregulated. Overall, the present demonstrated that by upregulating the expression of dbpA, LL-37 can promote the proliferation and invasion of tumour cells, and that this process depends on the NF-κB signalling pathway.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang W, Jia J, Li C, Duan Q, Yang J, Wang X, Li R, Chen C, Yan H, Zheng Y, Zheng Y, et al: Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A. Oncol Lett 12: 1745-1752, 2016.
APA
Wang, W., Jia, J., Li, C., Duan, Q., Yang, J., Wang, X. ... Zheng, Y. (2016). Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A. Oncology Letters, 12, 1745-1752. https://doi.org/10.3892/ol.2016.4865
MLA
Wang, W., Jia, J., Li, C., Duan, Q., Yang, J., Wang, X., Li, R., Chen, C., Yan, H., Zheng, Y."Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A". Oncology Letters 12.3 (2016): 1745-1752.
Chicago
Wang, W., Jia, J., Li, C., Duan, Q., Yang, J., Wang, X., Li, R., Chen, C., Yan, H., Zheng, Y."Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A". Oncology Letters 12, no. 3 (2016): 1745-1752. https://doi.org/10.3892/ol.2016.4865