Open Access

Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway

Corrigendum in: /10.3892/ol.2017.6464

  • Authors:
    • Jiao Zhang
    • Ling Guo
    • Xia Zhou
    • Fengyun Dong
    • Liqun Li
    • Zuowang Cheng
    • Yinghua Xu
    • Jiyong Liang
    • Qi Xie
    • Ju Liu
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/ol.2016.4870
  • Pages: 1896-1900
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiogenesis is required for the growth and metastasis of solid tumors. The anti-malarial agent dihydroartemisinin (DHA) demonstrates potent anti-angiogenic activity, but the underlying molecular mechanisms are not yet fully understood. During the process of angiogenesis, endothelial cells migrating from existing capillaries may undergo programmed cell death after detaching from the extracellular matrix, a process that is defined as anchorage‑dependent apoptosis or anoikis. In the present study, DHA‑induced cell death was compared in human umbilical vein endothelial cells (HUVECs) cultured in suspension and attached to culture plates. In suspended HUVECs, the cell viability was decreased and apoptosis was increased with the treatment of 50 µM DHA for 5 h, while the same treatment did not affect the attached HUVECs. In addition, 50 µM DHA increased the phosphorylation of c‑Jun N‑terminal kinase (JNK) in suspended HUVECs, but not in attached HUVECs, for up to 5 h of treatment. The JNK inhibitor, SP600125, reversed DHA‑induced cell death in suspended HUVECs, suggesting that the JNK pathway may mediate DHA‑induced endothelial cell anoikis. The data from the present study indicates a novel mechanism for understanding the anti-angiogenic effects of DHA, which may be used as a component for chemotherapy.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang J, Guo L, Zhou X, Dong F, Li L, Cheng Z, Xu Y, Liang J, Xie Q, Liu J, Liu J, et al: Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway Corrigendum in /10.3892/ol.2017.6464. Oncol Lett 12: 1896-1900, 2016
APA
Zhang, J., Guo, L., Zhou, X., Dong, F., Li, L., Cheng, Z. ... Liu, J. (2016). Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway Corrigendum in /10.3892/ol.2017.6464. Oncology Letters, 12, 1896-1900. https://doi.org/10.3892/ol.2016.4870
MLA
Zhang, J., Guo, L., Zhou, X., Dong, F., Li, L., Cheng, Z., Xu, Y., Liang, J., Xie, Q., Liu, J."Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway Corrigendum in /10.3892/ol.2017.6464". Oncology Letters 12.3 (2016): 1896-1900.
Chicago
Zhang, J., Guo, L., Zhou, X., Dong, F., Li, L., Cheng, Z., Xu, Y., Liang, J., Xie, Q., Liu, J."Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway Corrigendum in /10.3892/ol.2017.6464". Oncology Letters 12, no. 3 (2016): 1896-1900. https://doi.org/10.3892/ol.2016.4870