Open Access

Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging

  • Authors:
    • Regina Willecke‑Hochmuth
    • Katharina Pachmann
    • Joachim Drevs
  • View Affiliations

  • Published online on: July 18, 2016     https://doi.org/10.3892/ol.2016.4878
  • Pages: 1711-1716
  • Copyright: © Willecke‑Hochmuth et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The detection and characterisation of tumour-derived circulating epithelial tumor cells (CETCs) or circulating tumor cells (CTCs) have been a main focus of basic oncological research over previous years. Numerous studies in the past decade have shown that CTCs are a promising tool for the estimation of the risk for metastatic relapse. The present observational study describes treatment results using tumour imaging and the quantification of CTCs. A group of 14 patients with advanced carcinomas was followed during their anticancer treatments. CTC numbers were serially detected and treatment success was estimated by positron emission tomography‑computed tomography. A connection was found between tumour remission and a decreasing CTC count in 83%, a connection between stable disease and stable CTC numbers in 78% and a connection between progressive disease (PD) and an increase in CTC count in 50% of cases. In the patients with PD, an incomplete response was observed affecting the CTCs, but not the solid region of the tumour. As a result of this study, it may be concluded that patients with solid tumours benefit from serial quantification of CTCs in addition to imaging, as this combination of techniques provides a more sensitive result than imaging alone.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Willecke‑Hochmuth R, Pachmann K and Drevs J: Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging. Oncol Lett 12: 1711-1716, 2016
APA
Willecke‑Hochmuth, R., Pachmann, K., & Drevs, J. (2016). Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging. Oncology Letters, 12, 1711-1716. https://doi.org/10.3892/ol.2016.4878
MLA
Willecke‑Hochmuth, R., Pachmann, K., Drevs, J."Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging". Oncology Letters 12.3 (2016): 1711-1716.
Chicago
Willecke‑Hochmuth, R., Pachmann, K., Drevs, J."Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging". Oncology Letters 12, no. 3 (2016): 1711-1716. https://doi.org/10.3892/ol.2016.4878