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Article Open Access

miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression

  • Authors:
    • Wenxia Hu
    • Pule Jin
    • Cuimin Ding
    • Wei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050012, P.R. China, Department of Oncology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1901-1905
    |
    Published online on: July 19, 2016
       https://doi.org/10.3892/ol.2016.4881
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Abstract

Increasing evidence has shown that microRNA (miRNA) is extensively involved in the pathophysiology of lung cancer. Microarray data demonstrated the increasing levels of miR-19a in the peripheral blood from patients suffering from lung cancer, which is closely associated with poor prognosis of lung cancer. However, the underlying molecular mechanism of miR-19a remains to be determined. The results of the present study showed a higher expression of miR-19a compared with normal bronchial epithelial cells. Furthermore, lentivirus vectors were constructed to establish cell lines that over­expressed and knocked out miR-19a in order to study the role of miR-19a on the metastasis and proliferation of lung cancer cells. Investigation into the underlying mechanism of miR-19a, revealed that MXD1 may be the key gene targeting miR-19a, participating in the process of proliferation and metastasis of lung cancer cells.
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1 

Ettinger DS, Akerley W, Borghaei H, Chang AC, Cheney RT, Chirieac LR, DAmico TA, Demmy TL, Ganti AKP, Govindan R, et al: NCCN (National Comprehensive Cancer Network): Non-small cell lung cancer. J Natl Compr Canc Netw. 10:1236–1271. 2012.PubMed/NCBI

2 

Goldstraw P, Ball D, Jett JR, Le Chevalier T, Lim E, Nicholson AG and Shepherd FA: Non-small-cell lung cancer. Lancet. 378:1727–1740. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, et al: Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 363:733–742. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Qi J and Mu D: MicroRNAs and lung cancers: from pathogenesis to clinical implications. Front Med. 6:134–155. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wang Y, Zhang X, Liu L, Li H, Yu J, Wang C and Ren X: Clinical implication of microrna for lung cancer. Cancer Biother Radiopharm. 28:261–267. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Skrzypski M, Dziadziuszko R and Jassem J: MicroRNA in lung cancer diagnostics and treatment. Mutat Res. 717:25–31. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Lin PY, Yu SL and Yang PC: MicroRNA in lung cancer. Br J Cancer. 103:1144–1148. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Li Y, Zhang D, Chen C, Ruan Z, Li Y and Huang Y: MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1. Mol Biol Cell. 23:1423–1434. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, et al: MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest. 120:1298–1309. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Liu XH, Lu KH, Wang KM, Sun M, Zhang EB, Yang JS, Yin DD, Liu ZL, Zhou J, Liu ZJ, et al: MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC Cancer. 12:3482012. View Article : Google Scholar : PubMed/NCBI

11 

Luo W, Huang B, Li Z, Li H, Sun L, Zhang Q, Qiu X and Wang E: MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. PLoS One. 8:e647592013. View Article : Google Scholar : PubMed/NCBI

12 

Mei Z, He Y, Feng J, Shi J, Du Y, Qian L, Huang Q and Jie Z: MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2. FEBS Lett. 588:3055–3061. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ohdaira H, Sekiguchi M, Miyata K and Yoshida K: MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells. Cell Prolif. 45:32–38. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Bonauer A and Dimmeler S: The microRNA-17-92 cluster: still a miRacle? Cell Cycle. 8:3866–3873. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Lin Q, Chen T, Lin Q, Lin G, Lin J, Chen G and Guo L: Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer. J Surg Oncol. 107:767–771. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Wu Q, Yang Z, An Y, Hu H, Yin J, Zhang P, Nie Y, Wu K, Shi Y and Fan D: MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1. Cell Death Dis. 5:e11442014. View Article : Google Scholar : PubMed/NCBI

17 

Ha TY: MicroRNAs in human diseases: From cancer to cardiovascular disease. Immune Netw. 11:135–154. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, DAndrea A, Sander C and Ventura A: Genetic dissection of the miR-17-92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev. 23:2806–2811. 2009. View Article : Google Scholar : PubMed/NCBI

19 

ODonnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT: c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 435:839–843. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Ayer DE, Kretzner L and Eisenman RN: Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 72:211–222. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Song DW, Ryu JY, Kim JO, Kwon EJ and Kim H: The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Biochem J. 457:151–162. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Chen B, She S, Li D, Liu Z, Yang X, Zeng Z and Liu F: Role of miR-19a targeting TNF-α in mediating ulcerative colitis. Scand J Gastroenterol. 48:815–824. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Qin S, Ai F, Ji WF, Rao W, Zhang HC and Yao WJ: miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric cancer. Asian Pac J Cancer Prev. 14:835–840. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Pezzolesi MG, Platzer P, Waite KA and Eng C: Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in cowden syndrome. Am J Hum Genet. 82:1141–1149. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Xu XM, Wang XB, Chen MM, Liu T, Li YX, Jia WH, Liu M, Li X and Tang H: MicroRNA-19a and −19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. Cancer Lett. 322:148–158. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Wu Q, Yang Z, An Y, Hu H, Yin J, Zhang P, Nie Y, Wu K, Shi Y and Fan D: MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1. Cell Death Dis. 5:e11442014. View Article : Google Scholar : PubMed/NCBI

27 

Ohta Y, Hamada Y, Saitoh N and Katsuoka K: Effect of the transcriptional repressor Mad1 on proliferation of human melanoma cells. Exp Dermatol. 11:439–447. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu W, Jin P, Ding C and Liu W: miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression. Oncol Lett 12: 1901-1905, 2016.
APA
Hu, W., Jin, P., Ding, C., & Liu, W. (2016). miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression. Oncology Letters, 12, 1901-1905. https://doi.org/10.3892/ol.2016.4881
MLA
Hu, W., Jin, P., Ding, C., Liu, W."miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression". Oncology Letters 12.3 (2016): 1901-1905.
Chicago
Hu, W., Jin, P., Ding, C., Liu, W."miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression". Oncology Letters 12, no. 3 (2016): 1901-1905. https://doi.org/10.3892/ol.2016.4881
Copy and paste a formatted citation
x
Spandidos Publications style
Hu W, Jin P, Ding C and Liu W: miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression. Oncol Lett 12: 1901-1905, 2016.
APA
Hu, W., Jin, P., Ding, C., & Liu, W. (2016). miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression. Oncology Letters, 12, 1901-1905. https://doi.org/10.3892/ol.2016.4881
MLA
Hu, W., Jin, P., Ding, C., Liu, W."miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression". Oncology Letters 12.3 (2016): 1901-1905.
Chicago
Hu, W., Jin, P., Ding, C., Liu, W."miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression". Oncology Letters 12, no. 3 (2016): 1901-1905. https://doi.org/10.3892/ol.2016.4881
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