miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression

Hu,Wenxia; Jin,Pule; Ding,Cuimin; Liu,Wei

doi:10.3892/ol.2016.4881

miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression

Authors:
- Wenxia Hu
- Pule Jin
- Cuimin Ding
- Wei Liu
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Affiliations: Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050012, P.R. China, Department of Oncology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
Published online on: July 19, 2016 https://doi.org/10.3892/ol.2016.4881
Pages: 1901-1905
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increasing evidence has shown that microRNA (miRNA) is extensively involved in the pathophysiology of lung cancer. Microarray data demonstrated the increasing levels of miR-19a in the peripheral blood from patients suffering from lung cancer, which is closely associated with poor prognosis of lung cancer. However, the underlying molecular mechanism of miR-19a remains to be determined. The results of the present study showed a higher expression of miR-19a compared with normal bronchial epithelial cells. Furthermore, lentivirus vectors were constructed to establish cell lines that overexpressed and knocked out miR-19a in order to study the role of miR-19a on the metastasis and proliferation of lung cancer cells. Investigation into the underlying mechanism of miR-19a, revealed that MXD1 may be the key gene targeting miR-19a, participating in the process of proliferation and metastasis of lung cancer cells.

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