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Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells

  • Authors:
    • Andreia Mota Sousa
    • Margarida Rei
    • Rita Freitas
    • Sara Ricardo
    • Thomas Caffrey
    • Leonor David
    • Raquel Almeida
    • Michael Anthony Hollingsworth
    • Filipe Santos‑Silva
  • View Affiliations / Copyright

    Affiliations: Institute of Research and Innovation in Health, University of Porto, Porto 4200‑135, Portugal, Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, NE 68198‑5950, USA
    Copyright: © Sousa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1811-1817
    |
    Published online on: July 20, 2016
       https://doi.org/10.3892/ol.2016.4888
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Abstract

Despite the fact that the biological function of cluster of differentiation (CD)133 remains unclear, this glycoprotein is currently used in the identification and isolation of tumor-initiating cells from certain malignant tumors, including pancreatic cancer. In the present study, the involvement of mucin 1 (MUC1) in the signaling pathways of a highly tumorigenic CD133+ cellular subpopulation sorted from the pancreatic cancer cell line HPAF‑II was evaluated. The expression of MUC1‑cytoplasmic domain (MUC1‑CD) and oncogenic signaling transducers (epidermal growth factor receptor, protein kinase C delta, glycogen synthase kinase 3 beta and growth factor receptor‑bound protein 2), as well as the association between MUC1 and β‑catenin, were characterized in HPAF‑II CD133+ and CD133low cell subpopulations and in tumor xenografts generated from these cells. Compared with HPAF CD133low cells, HPAF‑II CD133+ cancer cells exhibited increased tumorigenic potential in immunocompromised mice, which was associated with overexpression of MUC1 and with the accordingly altered expression profile of MUC1‑associated signaling partners. Additionally, MUC1‑CD/β-catenin interactions were increased both in the HPAF‑II CD133+ cell subpopulation and derived tumor xenografts compared with HPAF CD133low cells. These results suggest that, in comparison with HPAF CD133low cells, CD133+ cells exhibit higher expression of MUC1, which contributes to their tumorigenic phenotype through increased interaction between MUC1‑CD and β-catenin, which in turn modulates oncogenic signaling cascades.
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1 

Yin AH, Miraglia S, Zanjani ED, AlmeidaPorada G, Ogawa M, Leary AG, Olweus J, Kearney J and Buck DW: AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood. 90:5002–5012. 1997.PubMed/NCBI

2 

Miraglia S, Godfrey W, Yin AH, Atkins K, Warnke R, Holden JT, Bray RA, Waller EK and Buck DW: A novel five-transmembrane hematopoietic stem cell antigen: Isolation, characterization, and molecular cloning. Blood. 90:5013–5021. 1997.PubMed/NCBI

3 

Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J and Dirks PB: Identification of a cancer stem cell in human brain tumors. Cancer Res. 63:5821–5828. 2003.PubMed/NCBI

4 

Todaro M, Francipane MG, Medema JP and Stassi G: Colon cancer stem cells: Promise of targeted therapy. Gastroenterology. 138:2151–2162. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Chen S, Song X, Chen Z, Li X, Li M, Liu H and Li J: CD133 expression and the prognosis of colorectal cancer: A systematic review and meta-analysis. PLoS One. 8:e563802013. View Article : Google Scholar : PubMed/NCBI

6 

Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA. 104:10158–10163. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ and Heeschen C: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 1:313–323. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 67:1030–1037. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Florek M, Haase M, Marzesco AM, Freund D, Ehninger G, Huttner WB and Corbeil D: Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res. 319:15–26. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, et al: CD133 expression is not restricted to stem cells, and both CD133+ and CD133, metastatic colon cancer cells initiate tumors. J Clin Invest. 118:2111–2120. 2008.PubMed/NCBI

11 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Collins A and Bloomston M: Diagnosis and management of pancreatic cancer. Minerva Gastroenterol Dietol. 55:445–454. 2009.PubMed/NCBI

13 

Moriyama T, Ohuchida K, Mizumoto K, Cui L, Ikenaga N, Sato N and Tanaka M: Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells. Cancer. 116:3357–3368. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Nomura A, Banerjee S, Chugh R, Dudeja V, Yamamoto M, Vickers SM and Saluja AK: CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer. Oncotarget. 6:8313–8322. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Gendler SJ: MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia. 6:339–353. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Costa NR, Paulo P, Caffrey T, Hollingsworth MA and Santos-Silva F: Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line. PLoS One. 6:e269702011. View Article : Google Scholar : PubMed/NCBI

17 

Jonckheere N and Van Seuningen I: The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie. 92:1–11. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, Bajaj E, Shanmugam K, Lee YY, Hwang SI, et al: MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene. 30:1449–1459. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Carraway KL III, Funes M, Workman HC and Sweeney C: Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr Top Dev Biol. 78:1–22. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Bafna S, Kaur S and Batra SK: Membrane-bound mucins: The mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene. 29:2893–2904. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Singh AP, Chauhan SC, Bafna S, Johansson SL, Smith LM, Moniaux N, Lin MF and Batra SK: Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. Prostate. 66:421–429. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Carson DD: The cytoplasmic tail of MUC1: A very busy place. Sci Signal. 1:pe352008. View Article : Google Scholar : PubMed/NCBI

23 

Yamamoto M, Bharti A, Li Y and Kufe D: Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem. 272:12492–12494. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Huang L, Chen D, Liu D, Yin L, Kharbanda S and Kufe D: MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res. 65:10413–10422. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Fessler SP, Wotkowicz MT, Mahanta SK and Bamdad C: MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Breast Cancer Res Treat. 118:113–124. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Hikita ST, Kosik KS, Clegg DO and Bamdad C: MUC1* mediates the growth of human pluripotent stem cells. PLoS One. 3:e33122008. View Article : Google Scholar : PubMed/NCBI

27 

Curry JM, Thompson KJ, Rao SG, Besmer DM, Murphy AM, Grdzelishvili VZ, Ahrens WA, McKillop IH, Sindram D, Iannitti DA, et al: The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. J Surg Oncol. 107:713–722. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Suvarna SK, Layton C and Bancroft JD: The hematoxylins and eosinBancroft's Theory and Practice of Histological Techniques. 7th. Churchill Livingstone; London: pp. 178–179. 2013

29 

Moon RT, Kohn AD, De Ferrari GV and Kaykas A: WNT and beta-catenin signalling: Diseases and therapies. Nat Rev Genet. 5:691–701. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Metzgar RS, Gaillard MT, Levine SJ, Tuck FL, Bossen EH and Borowitz MJ: Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies. Cancer Res. 42:601–608. 1982.PubMed/NCBI

31 

Vathipadiekal V, Saxena D, Mok SC, Hauschka PV, Ozbun L and Birrer MJ: Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer. PLoS One. 7:e290792012. View Article : Google Scholar : PubMed/NCBI

32 

Yoon CH, Kim MJ, Kim RK, Lim EJ, Choi KS, An S, Hwang SG, Kang SG, Suh Y, Park MJ and Lee SJ: c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells. Oncogene. 31:4655–4666. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Rohner A, Spilker ME, Lam JL, Pascual B, Bartkowski D, Li QJ, Yang AH, Stevens G, Xu M, Wells PA, et al: Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol Cancer Ther. 11:57–65. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Horn G, Gaziel A, Wreschner DH, Smorodinsky NI and Ehrlich M: ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1. Exp Cell Res. 315:1490–1504. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Vos HL, de Vries Y and Hilkens J: The mouse episialin (Muc1) gene and its promoter: Rapid evolution of the repetitive domain in the protein. Biochem Biophys Res Commun. 181:121–130. 1991. View Article : Google Scholar : PubMed/NCBI

36 

Baldus SE, Mönig SP, Huxel S, Landsberg S, Hanisch FG, Engelmann K, Schneider PM, Thiele J, Hölscher AH and Dienes HP: MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin Cancer Res. 10:2790–2796. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R and Birchmeier W: Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 382:638–642. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Huang L, Ren J, Chen D, Li Y, Kharbanda S and Kufe D: MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation. Cancer Biol Ther. 2:702–706. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Li Y and Kufe D: The human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn). Biochem Biophys Res Commun. 281:440–443. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Ren J, Li Y and Kufe D: Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J Biol Chem. 277:17616–17622. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Schroeder JA, Thompson MC, Gardner MM and Gendler SJ: Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276:13057–13064. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Wen Y, Caffrey TC, Wheelock MJ, Johnson KR and Hollingsworth MA: Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin. J Biol Chem. 278:38029–38039. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Yuan Z, Wong S, Borrelli A and Chung MA: Down-regulation of MUC1 in cancer cells inhibits cell migration by promoting E-cadherin/catenin complex formation. Biochem Biophys Res Commun. 362:740–746. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, et al: MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter. Cancer Lett. 346:225–236. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sousa AM, Rei M, Freitas R, Ricardo S, Caffrey T, David L, Almeida R, Hollingsworth MA and Santos‑Silva F: Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells. Oncol Lett 12: 1811-1817, 2016.
APA
Sousa, A.M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L. ... Santos‑Silva, F. (2016). Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells. Oncology Letters, 12, 1811-1817. https://doi.org/10.3892/ol.2016.4888
MLA
Sousa, A. M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L., Almeida, R., Hollingsworth, M. A., Santos‑Silva, F."Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells". Oncology Letters 12.3 (2016): 1811-1817.
Chicago
Sousa, A. M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L., Almeida, R., Hollingsworth, M. A., Santos‑Silva, F."Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells". Oncology Letters 12, no. 3 (2016): 1811-1817. https://doi.org/10.3892/ol.2016.4888
Copy and paste a formatted citation
x
Spandidos Publications style
Sousa AM, Rei M, Freitas R, Ricardo S, Caffrey T, David L, Almeida R, Hollingsworth MA and Santos‑Silva F: Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells. Oncol Lett 12: 1811-1817, 2016.
APA
Sousa, A.M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L. ... Santos‑Silva, F. (2016). Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells. Oncology Letters, 12, 1811-1817. https://doi.org/10.3892/ol.2016.4888
MLA
Sousa, A. M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L., Almeida, R., Hollingsworth, M. A., Santos‑Silva, F."Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells". Oncology Letters 12.3 (2016): 1811-1817.
Chicago
Sousa, A. M., Rei, M., Freitas, R., Ricardo, S., Caffrey, T., David, L., Almeida, R., Hollingsworth, M. A., Santos‑Silva, F."Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells". Oncology Letters 12, no. 3 (2016): 1811-1817. https://doi.org/10.3892/ol.2016.4888
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