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September-2016 Volume 12 Issue 3

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Review

The function of homeobox genes and lncRNAs in cancer (Review)

  • Authors:
    • Yingchao Wang
    • Yuan Dang
    • Jingfeng Liu
    • Xiaojuan Ouyang
  • View Affiliations / Copyright

    Affiliations: The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Experimental Medicine, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China
  • Pages: 1635-1641
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    Published online on: July 21, 2016
       https://doi.org/10.3892/ol.2016.4901
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Abstract

Recently, the homeobox (HOX) gene family has been reported as a factor in tumorigenesis. In the human genome, the HOX gene family contains 4 clusters with 39 genes and multiple transcripts. Mutation or abnormal expression of genes is responsible for developmental disorders. In addition, changes in the levels and activation of certain HOX genes has been associated with the development of cancer. Long non‑coding RNAs (lncRNAs) have also been identified to serve critical functions in cancer. Although a limited number of lncRNAs have been previously investigated, the list of functional lncRNA genes has recently grown. Two of the most important and well‑studied lncRNAs and HOX transcript genes are HOX transcript antisense RNA (HOTAIR) and HOXA distal transcript antisense RNA (HOTTIP). The present study aimed to review not only the function of the HOTAIR and HOTTIP genes in certain forms of cancer, but also to review other HOX genes and protein functions in cancer, particularly HOX family genes associated with lncRNAs.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Dang Y, Liu J and Ouyang X: The function of homeobox genes and lncRNAs in cancer (Review). Oncol Lett 12: 1635-1641, 2016.
APA
Wang, Y., Dang, Y., Liu, J., & Ouyang, X. (2016). The function of homeobox genes and lncRNAs in cancer (Review). Oncology Letters, 12, 1635-1641. https://doi.org/10.3892/ol.2016.4901
MLA
Wang, Y., Dang, Y., Liu, J., Ouyang, X."The function of homeobox genes and lncRNAs in cancer (Review)". Oncology Letters 12.3 (2016): 1635-1641.
Chicago
Wang, Y., Dang, Y., Liu, J., Ouyang, X."The function of homeobox genes and lncRNAs in cancer (Review)". Oncology Letters 12, no. 3 (2016): 1635-1641. https://doi.org/10.3892/ol.2016.4901
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Dang Y, Liu J and Ouyang X: The function of homeobox genes and lncRNAs in cancer (Review). Oncol Lett 12: 1635-1641, 2016.
APA
Wang, Y., Dang, Y., Liu, J., & Ouyang, X. (2016). The function of homeobox genes and lncRNAs in cancer (Review). Oncology Letters, 12, 1635-1641. https://doi.org/10.3892/ol.2016.4901
MLA
Wang, Y., Dang, Y., Liu, J., Ouyang, X."The function of homeobox genes and lncRNAs in cancer (Review)". Oncology Letters 12.3 (2016): 1635-1641.
Chicago
Wang, Y., Dang, Y., Liu, J., Ouyang, X."The function of homeobox genes and lncRNAs in cancer (Review)". Oncology Letters 12, no. 3 (2016): 1635-1641. https://doi.org/10.3892/ol.2016.4901
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