HPV strain distribution in patients with genital warts in a female population sample

Boda,Daniel; Neagu,Monica; Constantin,Carolina; Voinescu,Razvan  Nicolae; Caruntu,Constantin; Zurac,Sabina; Spandidos,Demetrios   A.; Drakoulis,Nikolaos; Tsoukalas,Dimitrios; Tsatsakis,Aristides   M.

doi:10.3892/ol.2016.4903

HPV strain distribution in patients with genital warts in a female population sample

Authors:
- Daniel Boda
- Monica Neagu
- Carolina Constantin
- Razvan Nicolae Voinescu
- Constantin Caruntu
- Sabina Zurac
- Demetrios A. Spandidos
- Nikolaos Drakoulis
- Dimitrios Tsoukalas
- Aristides M. Tsatsakis
View Affiliations

Affiliations: Dermatology Research Laboratory, ‘Carol Davila’ University of Medicine and Pharmacy, Bucharest 050474, Romania, Department of Immunology, ‘Victor Babes’ National Institute of Pathology, Bucharest 050096, Romania, The Institute for World Economy, Bucharest 050711, Romania, Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, Colentina University Hospital, Bucharest 020125, Romania, Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71409, Greece, Research Laboratory of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens 157 71, Greece, Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion 71003, Greece
Published online on: July 22, 2016 https://doi.org/10.3892/ol.2016.4903
Pages: 1779-1782
Copyright: © Boda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high- and low-risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts. We found differences in the distribution of high‑/low‑risk strains and the incidence of high‑risk strains was found to occur mainly in females under 35 years of age. The data from our study suggest that a detailed oral, rectal and genital identification of high‑risk strains should be performed to visualize the entire pattern of possible triggers of carcinogenesis.

View Figures

View References

1	Škamperle M, Kocjan BJ, Maver PJ, Seme K and Poljak M: Human papillomavirus (HPV) prevalence and HPV type distribution in cervical, vulvar, and anal cancers in central and eastern Europe. Acta Dermatovenerol Alp Pannonica Adriat. 22:1–5. 2013.PubMed/NCBI
2	Voidăzan S, Tarcea M, Morariu SH, Grigore A and Dobreanu M: Human papillomavirus vaccine - knowledge and attitudes among parents of children aged 10–14 years: A cross-sectional study, Tirgu Mures, Romania. Cent Eur J Public Health. 24:29–38. 2016. View Article : Google Scholar : PubMed/NCBI
3	Salavastru CM, Niculescu MC, Zota A, Nicola G, Morariu HS, Solovan C, Patrascu V, Popovici G, Vladuta R, Panduru M, et al: Epidemiological aspects of genital warts in romania - a 2012 retrospective survey. Maedica (Buchar). 9:144–150. 2014.PubMed/NCBI
4	Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlée F, Hildesheim A, Schiffman MH, Scott DR and Apple RJ: Improved amplification of genital human papillomaviruses. J Clin Microbiol. 38:357–361. 2000.PubMed/NCBI
5	Raţiu MP, Purcărea I, Popa F, Purcărea VL, Purcărea TV, Lupuleasa D and Boda D: Escaping the economic turn down through performing employees, creative leaders and growth driver capabilities in the Romanian pharmaceutical industry. Farmacia. 59:119–130. 2011.
6	Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC, Su J, Xu F and Weinstock H: Sexually transmitted infections among US women and men: Prevalence and incidence estimates, 2008. Sex Transm Dis. 40:187–193. 2013. View Article : Google Scholar : PubMed/NCBI
7	Owusu-Edusei K Jr, Chesson HW, Gift TL, Tao G, Mahajan R, Ocfemia MC and Kent CK: The estimated direct medical cost of selected sexually transmitted infections in the United States, 2008. Sex Transm Dis Mar. 40:197–201. 2013. View Article : Google Scholar
8	Workowski KA and Berman S: Centers for Disease Control and Prevention (CDC): Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 59(RR-12): 1–110. 2010.PubMed/NCBI
9	Koshiol J, Lindsay L, Pimenta JM, Poole C, Jenkins D and Smith JS: Persistent human papillomavirus infection and cervical neoplasia: A systematic review and meta-analysis. Am J Epidemiol. 168:123–137. 2008. View Article : Google Scholar : PubMed/NCBI
10	Louvanto K, Rintala MA, Syrjänen KJ, Grénman SE and Syrjänen SM: Genotype-specific persistence of genital human papillomavirus (HPV) infections in women followed for 6 years in the Finnish Family HPV Study. J Infect Dis. 202:436–444. 2010. View Article : Google Scholar : PubMed/NCBI
11	Kjær SK, Frederiksen K, Munk C and Iftner T: Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: Role of persistence. J Natl Cancer Inst. 102:1478–1488. 2010. View Article : Google Scholar : PubMed/NCBI
12	Syrjänen K, Shabalova I, Naud P, Kozachenko V, Derchain S, Zakharchenko S, Roteli-Martins C, Nerovjna R, Longatto-Filho A, Kljukina L, et al: NIS and LAMS Study Research Groups: Risk estimates for persistent high-risk human papillomavirus infections as surrogate endpoints of progressive cervical disease critically depend on reference category: Analysis of the combined prospective cohort of the New Independent States of the Former Soviet Union and Latin American Screening studies. Int J STD AIDS. 22:315–323. 2011. View Article : Google Scholar : PubMed/NCBI
13	Li N, Franceschi S, Howell-Jones R, Snijders PJ and Clifford GM: Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int J Cancer. 128:927–935. 2011. View Article : Google Scholar : PubMed/NCBI
14	Mammas IN and Spandidos DA: Fighting against human papillomavirus: the 25-year old contribution of the University of Crete School of Medicine. J BUON. 20:17–21. 2015.PubMed/NCBI
15	Clifford GM, Gonçalves MA and Franceschi S: HPV and HIV Study Group: Human papillomavirus types among women infected with HIV: A meta-analysis. AIDS. 20:2337–2344. 2006. View Article : Google Scholar : PubMed/NCBI
16	Du J, Nordfors C, Ährlund-Richter A, Sobkowiak M, Romanitan M, Näsman A, Andersson S, Ramqvist T and Dalianis T: Prevalence of oral human papillomavirus infection among youth, Sweden. Emerg Infect Dis. 18:1468–1471. 2012. View Article : Google Scholar : PubMed/NCBI
17	Giraldo P, Gonçalves AK, Pereira SA, Barros-Mazon S, Gondo ML and Witkin SS: Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions. Eur J Obstet Gynecol Reprod Biol. 126:104–106. 2006. View Article : Google Scholar : PubMed/NCBI
18	Termine N, Giovannelli L, Matranga D, Caleca MP, Bellavia C, Perino A and Campisi G: Oral human papillomavirus infection in women with cervical HPV infection: New data from an Italian cohort and a metanalysis of the literature. Oral Oncol. 47:244–250. 2011. View Article : Google Scholar : PubMed/NCBI
19	De Marco F: Oxidative stress and HPV carcinogenesis. Viruses. 5:708–731. 2013. View Article : Google Scholar : PubMed/NCBI
20	Kofoed K, Sand C, Forslund O and Madsen K: Prevalence of human papillomavirus in anal and oral sites among patients with genital warts. Acta Derm Venereol. 94:207–211. 2014. View Article : Google Scholar : PubMed/NCBI
21	Căruntu C, Grigore C, Căruntu A, Diaconeasa A and Boda D: The role of stress in skin disease. Intern Med. 8:73–84. 2011.
22	Fang CY, Miller SM, Bovbjerg DH, Bergman C, Edelson MI, Rosenblum NG, Bove BA, Godwin AK, Campbell DE and Douglas SD: Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia. Ann Behav Med. 35:87–96. 2008. View Article : Google Scholar : PubMed/NCBI
23	Spandidos DA: A unified theory for the development of cancer. Biosci Rep. 6:691–708. 1986. View Article : Google Scholar : PubMed/NCBI
24	Spandidos DA: The cancer story. Cancer Biol Ther. 3:1184–1186. 2004. View Article : Google Scholar : PubMed/NCBI
25	Neagu M, Caruntu C, Constantin C, Boda D, Zurac S, Spandidos DA and Tsatsakis AM: Chemically induced skin carcinogenesis: Updates in experimental models (Review). Oncol Rep. 35:2516–2528. 2016.PubMed/NCBI
26	Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013. View Article : Google Scholar
27	Wu DW, Chuang CY, Lin WL, Sung WW, Cheng YW and Lee H: Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting. Carcinogenesis. 35:1823–1829. 2014. View Article : Google Scholar : PubMed/NCBI