Association of FGD1 polymorphisms with early-onset breast cancer

  • Authors:
    • Sarah Beasley
    • Phillip J. Buckhaults
    • Nancy G. Pedigo
    • Christopher L. Farrell
  • View Affiliations

  • Published online on: July 25, 2016     https://doi.org/10.3892/ol.2016.4911
  • Pages: 2071-2077
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Abstract

Recent cancer studies have suggested that the faciogenital dysplasia 1 (FGD1) gene may play a role in the development of tumor cells. Somatic alterations in the FGD1 gene and increased Fgd1 protein expression have been observed in many breast tumor cases. The present study sequenced the FGD1 gene in tumor DNA from 46 breast cancer patients using Ion Torrent sequencing. Three synonymous polymorphisms and one missense polymorphism were detected with next‑generation sequencing; however, no somatic mutations were observed. The Thr697 variant was identified in 18 patients with an average age at diagnosis of 55 years, which was a lower average age than patients without the polymorphism. In addition, a higher frequency of Thr697 was observed in African‑American patients. The Pro712 was observed in 15 breast cancer patients with an average age of 58 years, and was observed as a haplotype with the Thr697 variant in 28% of the breast cancer patients studied. The missense polymorphism (Ala226Thr) was identified in a 40‑year‑old female patient who had a recurrence of cancer. These polymorphisms (Ala226Thr, Thr697 and Pro712) may be associated with an earlier onset of breast cancer.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Beasley S, Buckhaults PJ, Pedigo NG and Farrell CL: Association of FGD1 polymorphisms with early-onset breast cancer. Oncol Lett 12: 2071-2077, 2016
APA
Beasley, S., Buckhaults, P.J., Pedigo, N.G., & Farrell, C.L. (2016). Association of FGD1 polymorphisms with early-onset breast cancer. Oncology Letters, 12, 2071-2077. https://doi.org/10.3892/ol.2016.4911
MLA
Beasley, S., Buckhaults, P. J., Pedigo, N. G., Farrell, C. L."Association of FGD1 polymorphisms with early-onset breast cancer". Oncology Letters 12.3 (2016): 2071-2077.
Chicago
Beasley, S., Buckhaults, P. J., Pedigo, N. G., Farrell, C. L."Association of FGD1 polymorphisms with early-onset breast cancer". Oncology Letters 12, no. 3 (2016): 2071-2077. https://doi.org/10.3892/ol.2016.4911