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Article Open Access

Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance

  • Authors:
    • Jing Zhang
    • Xiao‑Yu Chen
    • Ke‑Jian Huang
    • Wei‑Dong Wu
    • Tao Jiang
    • Jun Cao
    • Li‑Sheng Zhou
    • Zheng‑Jun Qiu
    • Chen Huang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai 200080, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2445-2450
    |
    Published online on: July 28, 2016
       https://doi.org/10.3892/ol.2016.4917
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Abstract

The aim of the present study was to investigate the expression of forkhead box M1 (FoxM1) and E-cadherin in tissues of gastric cancer in order to reveal any correlation between FoxM1, E‑cadherin and clinicopathological parameters. The association between FoxM1 and E‑cadherin in the development and progression of gastric cancer was also investigated. The expression of FoxM1 and E‑cadherin in gastric cancer and adjacent normal tissue on tissue microarray was detected using immunohistochemistry. The clinicopathological significance of FoxM1 and E‑cadherin in gastric cancer was explored, and the association between FoxM1 and E‑cadherin was further examined using statistical techniques. In gastric cancer tissues, the expression of FoxM1 and E‑cadherin was strongly positive, but it was weak in normal gastric mucosa. Overexpression of FoxM1 was evident in gastric cancer, and was associated with poor tumor differentiation (P<0.05), advanced tumor state (P<0.05) and lymph node (or distant) metastasis (P<0.05), whereas E‑cadherin had the opposite effects. Furthermore, the correlation between FoxM1 and E‑cadherin expression in gastric cancer tissue was negative. In conclusion, the high FoxM1 expression and low E‑cadherin expression in gastric cancer tissue suggests that these proteins play a critical role in the development and progression of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Chen XY, Huang KJ, Wu WD, Jiang T, Cao J, Zhou LS, Qiu ZJ and Huang C: Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance. Oncol Lett 12: 2445-2450, 2016.
APA
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J. ... Huang, C. (2016). Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance. Oncology Letters, 12, 2445-2450. https://doi.org/10.3892/ol.2016.4917
MLA
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J., Zhou, L., Qiu, Z., Huang, C."Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance". Oncology Letters 12.4 (2016): 2445-2450.
Chicago
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J., Zhou, L., Qiu, Z., Huang, C."Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance". Oncology Letters 12, no. 4 (2016): 2445-2450. https://doi.org/10.3892/ol.2016.4917
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Chen XY, Huang KJ, Wu WD, Jiang T, Cao J, Zhou LS, Qiu ZJ and Huang C: Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance. Oncol Lett 12: 2445-2450, 2016.
APA
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J. ... Huang, C. (2016). Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance. Oncology Letters, 12, 2445-2450. https://doi.org/10.3892/ol.2016.4917
MLA
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J., Zhou, L., Qiu, Z., Huang, C."Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance". Oncology Letters 12.4 (2016): 2445-2450.
Chicago
Zhang, J., Chen, X., Huang, K., Wu, W., Jiang, T., Cao, J., Zhou, L., Qiu, Z., Huang, C."Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance". Oncology Letters 12, no. 4 (2016): 2445-2450. https://doi.org/10.3892/ol.2016.4917
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